Studi Efek Pemberian Probiotik Multistrain terhadap Parameter Klinis Diabetes Melitus: Review Sistematik
Abstract
ABSTRACT
The purpose of this study was to analyze the study of the effects of multistrain probiotics on clinical parameters in diabetes mellitus to determine the condition of blood glucose and HbA1c so as to trigger inflammation. The research method uses a systematic review with the online scientific database Google Scholar, PubMed, Researchgate according to the inclusion and exclusion criteria. The results of this systematic review showed that 13 articles that had been extracted discussed the effects of giving probiotics as an alternative secondary treatment for complications of diabetes mellitus and 5 articles that were in accordance with the research objectives. From the results of a systematic review, it was concluded that probiotic treatment can reduce the level of resistance to HbA1c, GDP, GD2P and inflammatory mediator parts of diabetes mellitus.
Keywords: Diabetes mellitus, HbA1c, Probiotics, Proinflammation
References
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Asemi, Z., Zare, Z., Shakeri, H., Sabihi, S., & Esmaillzadeh, A. (2013). Effect of Multispecies Probiotic Supplements on Metabolic Profiles, hs-CRP, and Oxidative Stress in Patients with Type 2 Diabetes. Annals of Nutrition and Metabolism, 63(1–2), 1–9. https://doi.org/10.1159/000349922
Azad, Md. A. K., Sarker, M., Li, T., & Yin, J. (2018). Probiotic Species in the Modulation of Gut Microbiota: An Overview. BioMed Research International, 20(1), 1–8. https://doi.org/10.1155/2018/9478630
Bohlouli, J., Namjoo, I., Borzoo-Isfahani, M., Hojjati Kermani, M. A., Balouch Zehi, Z., & Moravejolahkami, A. R. (2021). Effect of Probiotics on Oxidative Stress and Inflammatory Status in Diabetic Nephropathy: A Systematic Review and Meta-Analysis of Clinical Trials. Heliyon, 7(1), e05925. https://doi.org/10.1016/j.heliyon.2021.e05925
Dai, Y., Quan, J., Xiong, L., Luo, Y., & Yi, B. (2022). Probiotics Improve Renal Function, Glucose, Lipids, Inflammation and Oxidative Stress in Diabetic Kidney Disease: A Systematic Review and Meta-Analysis. Renal Failure, 44(1), 862–880. https://doi.org/10.1080/0886022X.2022.2079522
Ding, L. N., Ding, W. Y., Ning, J., Wang, Y., Yan, Y., & Wang, Z. B. (2021). Effects of Probiotic Supplementation on Inflammatory Markers and Glucose Homeostasis in Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology, 12(1), 770861. https://doi.org/10.3389/fphar.2021.770861
Ejtahed, H. S., Mohtadi Nia, J., Homayouni Rad, A., Niafar, M., Asghari Jafarabadi, M., & Mofid, V. (2012). Probiotic Yogurt Improves Antioxidant Status in Type 2 Diabetic Patients. Nutrition, 28(5), 539–543. https://doi.org/10.1016/j.nut.2011.08.013
Firouzi, S., Majid, H. A., Ismail, A., Kamaruddin, N. A., & Barakatun Nisak, M. Y. (2017). Effect of Multi-Strain Probiotics (Multi-Strain Microbial Cell Preparation) on Glycemic Control and other Diabetes-Related Outcomes in People with Type 2 Diabetes: A Randomized Controlled Trial. European Journal of Nutrition, 56(4), 1535–1550. https://doi.org/10.1007/s00394-016-1199-8
Gurung, M., Li, Z., You, H., Rodrigues, R., Jump, D. B., Morgun, A., & Shulzhenko, N. (2020). Role of Gut Microbiota in Type 2 Diabetes Pathophysiology. EBioMedicine, 51, 102590. https://doi.org/10.1016/j. ebiom.2019.11.051
Hasanpour, A., Babajafari, S., Mazloomi, S. M., & Shams, M. (2023). The Effects of Soymilk Plus Probiotics Supplementation on Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial. BMC Endocrine Disorders, 23(1), 36. https://doi.org/10.1186/ s12902-023-01290-w
Hosainzadegn, H., & Hosainzadegan, M. (2021). Traditional Probiotic (Kefir) Effects on Glycated Hemoglobin A Level and Weight of an Indexed Diabetic Patient. 12(1).
Jaff, S., Gubari, M., Shab Bidar, S., & Djafarian, K. (2022). Effect of Probiotic Supplementation on Lipoprotein-Associated Phospholipase A2 in Type 2 Diabetic Patients: A Randomized Double-Blind Clinical Controlled Trial [Preprint]. In Review. https://doi.org/10.21203/rs.3.rs-2070122/v1
Jiang, H., Zhang, Y., Xu, D., & Wang, Q. (2021). Probiotics Ameliorates Glycemic Control of Patients with Diabetic Nephropathy: A Randomized Clinical Study. Journal of Clinical Laboratory Analysis, 35(4). https://doi. org/10.1002/jcla.23650
Kasinska, M. A., & Drzewoski, J. (2015). Effectiveness of Probiotics in Type 2 Diabetes: A Meta-Analysis. Polish Archives of Internal Medicine, 125(11), 803–813. https://doi.org/10.20452/pamw.3156
Khalili, L. (2019). The Effects of Lactobacillus casei on Glycemic Response, Serum Sirtuin1 and Fetuin-A Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Iranian Biomedical Journal, 23(1), 68–77. https://doi.org/10.29252/ibj.23.1.68
Kobyliak, N., Falalyeyeva, T., Mykhalchyshyn, G., Kyriienko, D., & Komissarenko, I. (2018). Effect of Alive Probiotic on Insulin Resistance in Type 2 Diabetes Patients: Randomized Clinical Trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 12(5), 617–624. https://doi.org/10.1016/j.dsx.2018.04.015
Kocsis, T., Molnár, B., Németh, D., Hegyi, P., Szakács, Z., Bálint, A., Garami, A., Soós, A., Márta, K., & Solymár, M. (2020). Probiotics have Beneficial Metabolic Effects in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Clinical Trials. Scientific Reports, 10(1), 11787. https://doi.org/10.1038/s41598-020-68440-1
Kurnianta, P. D. M., Ratnasari, P. M. D., & Arini, H. D. (2021). Ketercapaian Target Glikemik dan Analisis Faktor- Faktor Terkait pada Pasien Diabetes Tipe 2. Majalah Farmasi dan Famakologi, 25(2).
Li, C., Li, X., Han, H., Cui, H., Peng, M., Wang, G., & Wang, Z. (2016). Effect of Probiotics on Metabolic Profiles in Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized, Controlled Trials. Medicine, 95(26), e4088. https://doi.org/10.1097/MD.0000000000004088
Li, Y., Wu, Y., Wu, L., Qin, L., & Liu, T. (2022a). The Effects of Probiotic Administration on Patients with Prediabetes: A Meta-Analysis and Systematic Review. Journal of Translational Medicine, 20(1), 498. https:// doi.org/10.1186/s12967-022-03695-y
Liu, Y., Zheng, S., Cui, J., Guo, T., & Zhang, J. (2022b). Lactiplantibacillus Plantarum Y15 Alleviate Type 2 Diabetes in Mice via Modulating Gut Microbiota and Regulating NF-Κb and Insulin Signaling Pathway. Brazilian Journal of Microbiology, 53(2), 935–945. https://doi.org/10. 1007/s42770-022-00686-5
Mazloom, Z. (2013). Effect of Probiotics on Lipid Profile, Glycemic Control, Insulin Action, Oxidative Stress, and Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial. 38(1).
Mohammad Shahi, M., Veissi, M., Haidari, F., Shahbazian, H., Kaydani, G. A., & Mohammadi, F. (2014). Effects of Probiotic Yogurt Consumption on Inflammatory Biomarkers in Patients with Type 2 Diabetes [Text/html]. Biolmpacts; ISSN 2228-5652, 4(2). https://doi.org/10.5681/BI.2014.007
Naseri, K., Saadati, S., Ghaemi, F., Ashtary Larky, D., Asbaghi, O., Sadeghi, A., Afrisham, R., & de Courten, B. (2022). The Effects of Probiotic and Synbiotic Supplementation on Inflammation, Oxidative Stress, and Circulating Adiponectin and Leptin Concentration in Subjects with Prediabetes and Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review, Meta-Analysis, and Meta-Regression of Randomized Clinical Trials. European Journal of Nutrition. https://doi.org/10.1007/ s00394-022-03012-9
PintariÄ, M., & Langerholc, T. (2022). Probiotic Mechanisms Affecting Glucose Homeostasis: A Scoping Review. Life, 12(8), 1187. https://doi.org/10. 3390/life12081187
Putra, M. A. D., Suharti, N., & Anggraini, F. T. (2022). Peran Lactobacillus pada Diabetes Melitus Tipe 2. Jurnal Ilmu Kesehatan Indonesia, 3(1), 97–107. https://doi.org/10.25077/jikesi.v3i1.351
Razmpoosh, E., Javadi, A., Ejtahed, H. S., Mirmiran, P., Javadi, M., & Yousefinejad, A. (2019). The Effect of Probiotic Supplementation on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes: A Randomized Placebo Controlled Trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(1), 175–182. https://doi.org/10.1016/j. dsx.2018.08.008
Saha, S., Alam, N. N., & Rahman, S. M. N. (2021). The Role of Probiotic Supplementation on Insulin Resistance in Obesity-Associated Diabetes: A Mini-Review. MEDICINE & PHARMACOLOGY. https://doi.org/10. 20944/preprints202110.0134.v1
Saha, S., Rahman, S. M. N., & Alam, N. N. (2022). The role of probiotic supplementation on insulin resistance in obesity associated diabetes: A mini review. Biomedicine, 42(4), 651–656. https://doi.org/10.51248/. v42i4.1359
Salles, B. I. M., Cioffi, D., & Ferreira, S. R. G. (2020). Probiotics supplementation and insulin resistance: A systematic review. Diabetology & Metabolic Syndrome, 12(1), 98. https://doi.org/10.1186/s13098-020-00603-6
Shakeri, H., Hadaegh, H., Abedi, F., Tajabadi-Ebrahimi, M., Mazroii, N., Ghandi, Y., & Asemi, Z. (2014). Consumption of Synbiotic Bread Decreases Triacylglycerol and VLDL Levels While Increasing HDL Levels in Serum from Patients with Type-2 Diabetes. Lipids, 49(7), 695–701. https://doi.org/10.1007/s11745-014-3901-z
Å ola, K. F., Vladimir Knežević, S., HrabaÄ, P., Mucalo, I., Saso, L., & Verbanac, D. (2022). The effect of multistrain probiotics on functional constipation in the elderly: A randomized controlled trial. European Journal of Clinical Nutrition, 76(12), 1675–1681. https://doi.org/10.1038/s41430-022-01189-0
Souza, M. P. G., Mendes, R. C. M., Reis, D. M. dos, & Martins, M. Y. P. T. (2022). O efeito do uso de probióticos sobre glicemia de jejum, resistência à insulina e hemoglobina glicada em pessoas com Diabetes mellitus tipo 2: Uma revisão de literatura. Research, Society and Development, 11(5), e10411527972. https://doi.org/10.33448/rsd-v11i5.27972
Tao, Y. W., Gu, Y. L., Mao, X.Q., Zhang, L., & Pei, Y. F. (2020). Effects of probiotics on type II diabetes mellitus: A meta-analysis. Journal of Translational Medicine, 18(1), 30. https://doi.org/10.1186/s12967-020-02213-2
Tonucci, L. B., Olbrich dos Santos, K. M., Licursi de Oliveira, L., Rocha Ribeiro, S. M., & Duarte Martino, H. S. (2017). Clinical application of probiotics in type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled study. Clinical Nutrition, 36(1), 85–92. https://doi.org/10.1016/j.clnu. 2015.11.011
Wang, X., Yang, J., Qiu, X., Wen, Q., Liu, M., Zhou, D., & Chen, Q. (2021). Probiotics, Pre-biotics and Synbiotics in the Treatment of Pre-diabetes: A Systematic Review of Randomized Controlled Trials. Frontiers in Public Health, 9, 645035. https://doi.org/10.3389/fpubh.2021.645035
Wigati, L. I., Zuraida, R., & Fiana, D. N. (2022). Potensi Probiotik dalam Mikrobiota Usus sebagai Target Pengobatan Diabetes Mellitus. Diabetes Mellitus, 9(2).
Zhai, L., Wu, J., Lam, Y. Y., Kwan, H. Y., Bian, Z. X., & Wong, H. L. X. (2021). Gut Microbial Metabolites, Probiotics and Their Roles in Type 2 Diabetes. International Journal of Molecular Sciences, 22(23), 12846. https://doi. org/10.3390/ijms222312846
Zhang, Q., Wu, Y., & Fei, X. (2016). Effect of Probiotics on Glucose Metabolism in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials. Medicina, 52(1), 28–34. https://doi.org/10. 1016/j.medici.2015.11.008
Zhang, X., Zhang, Y., Luo, L., Le, Y., Li, Y., Yuan, F., Wu, Y., & Xu, P. (2023). The Beneficial Effects of a Multispecies Probiotic Supplement on Glycaemic Control and Metabolic Profile in Adults with Type 1 Diabetes: A Randomised, Double-Blinded, Placebo-Controlled Pilot-Study. Diabetes, Metabolic Syndrome and Obesity, Volume 16, 829–840. https://doi.org/10.2147/DMSO.S400119
Asemi, Z., Zare, Z., Shakeri, H., Sabihi, S., & Esmaillzadeh, A. (2013). Effect of Multispecies Probiotic Supplements on Metabolic Profiles, hs-CRP, and Oxidative Stress in Patients with Type 2 Diabetes. Annals of Nutrition and Metabolism, 63(1–2), 1–9. https://doi.org/10.1159/000349922
Azad, Md. A. K., Sarker, M., Li, T., & Yin, J. (2018). Probiotic Species in the Modulation of Gut Microbiota: An Overview. BioMed Research International, 20(1), 1–8. https://doi.org/10.1155/2018/9478630
Bohlouli, J., Namjoo, I., Borzoo-Isfahani, M., Hojjati Kermani, M. A., Balouch Zehi, Z., & Moravejolahkami, A. R. (2021). Effect of Probiotics on Oxidative Stress and Inflammatory Status in Diabetic Nephropathy: A Systematic Review and Meta-Analysis of Clinical Trials. Heliyon, 7(1), e05925. https://doi.org/10.1016/j.heliyon.2021.e05925
Dai, Y., Quan, J., Xiong, L., Luo, Y., & Yi, B. (2022). Probiotics Improve Renal Function, Glucose, Lipids, Inflammation and Oxidative Stress in Diabetic Kidney Disease: A Systematic Review and Meta-Analysis. Renal Failure, 44(1), 862–880. https://doi.org/10.1080/0886022X.2022.2079522
Ding, L. N., Ding, W. Y., Ning, J., Wang, Y., Yan, Y., & Wang, Z. B. (2021). Effects of Probiotic Supplementation on Inflammatory Markers and Glucose Homeostasis in Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology, 12(1), 770861. https://doi.org/10.3389/fphar.2021.770861
Ejtahed, H. S., Mohtadi Nia, J., Homayouni Rad, A., Niafar, M., Asghari Jafarabadi, M., & Mofid, V. (2012). Probiotic Yogurt Improves Antioxidant Status in Type 2 Diabetic Patients. Nutrition, 28(5), 539–543. https://doi.org/10.1016/j.nut.2011.08.013
Firouzi, S., Majid, H. A., Ismail, A., Kamaruddin, N. A., & Barakatun Nisak, M. Y. (2017). Effect of Multi-Strain Probiotics (Multi-Strain Microbial Cell Preparation) on Glycemic Control and other Diabetes-Related Outcomes in People with Type 2 Diabetes: A Randomized Controlled Trial. European Journal of Nutrition, 56(4), 1535–1550. https://doi.org/10.1007/s00394-016-1199-8
Gurung, M., Li, Z., You, H., Rodrigues, R., Jump, D. B., Morgun, A., & Shulzhenko, N. (2020). Role of Gut Microbiota in Type 2 Diabetes Pathophysiology. EBioMedicine, 51, 102590. https://doi.org/10.1016/j. ebiom.2019.11.051
Hasanpour, A., Babajafari, S., Mazloomi, S. M., & Shams, M. (2023). The Effects of Soymilk Plus Probiotics Supplementation on Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial. BMC Endocrine Disorders, 23(1), 36. https://doi.org/10.1186/ s12902-023-01290-w
Hosainzadegn, H., & Hosainzadegan, M. (2021). Traditional Probiotic (Kefir) Effects on Glycated Hemoglobin A Level and Weight of an Indexed Diabetic Patient. 12(1).
Jaff, S., Gubari, M., Shab Bidar, S., & Djafarian, K. (2022). Effect of Probiotic Supplementation on Lipoprotein-Associated Phospholipase A2 in Type 2 Diabetic Patients: A Randomized Double-Blind Clinical Controlled Trial [Preprint]. In Review. https://doi.org/10.21203/rs.3.rs-2070122/v1
Jiang, H., Zhang, Y., Xu, D., & Wang, Q. (2021). Probiotics Ameliorates Glycemic Control of Patients with Diabetic Nephropathy: A Randomized Clinical Study. Journal of Clinical Laboratory Analysis, 35(4). https://doi. org/10.1002/jcla.23650
Kasinska, M. A., & Drzewoski, J. (2015). Effectiveness of Probiotics in Type 2 Diabetes: A Meta-Analysis. Polish Archives of Internal Medicine, 125(11), 803–813. https://doi.org/10.20452/pamw.3156
Khalili, L. (2019). The Effects of Lactobacillus casei on Glycemic Response, Serum Sirtuin1 and Fetuin-A Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Iranian Biomedical Journal, 23(1), 68–77. https://doi.org/10.29252/ibj.23.1.68
Kobyliak, N., Falalyeyeva, T., Mykhalchyshyn, G., Kyriienko, D., & Komissarenko, I. (2018). Effect of Alive Probiotic on Insulin Resistance in Type 2 Diabetes Patients: Randomized Clinical Trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 12(5), 617–624. https://doi.org/10.1016/j.dsx.2018.04.015
Kocsis, T., Molnár, B., Németh, D., Hegyi, P., Szakács, Z., Bálint, A., Garami, A., Soós, A., Márta, K., & Solymár, M. (2020). Probiotics have Beneficial Metabolic Effects in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Clinical Trials. Scientific Reports, 10(1), 11787. https://doi.org/10.1038/s41598-020-68440-1
Kurnianta, P. D. M., Ratnasari, P. M. D., & Arini, H. D. (2021). Ketercapaian Target Glikemik dan Analisis Faktor- Faktor Terkait pada Pasien Diabetes Tipe 2. Majalah Farmasi dan Famakologi, 25(2).
Li, C., Li, X., Han, H., Cui, H., Peng, M., Wang, G., & Wang, Z. (2016). Effect of Probiotics on Metabolic Profiles in Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized, Controlled Trials. Medicine, 95(26), e4088. https://doi.org/10.1097/MD.0000000000004088
Li, Y., Wu, Y., Wu, L., Qin, L., & Liu, T. (2022a). The Effects of Probiotic Administration on Patients with Prediabetes: A Meta-Analysis and Systematic Review. Journal of Translational Medicine, 20(1), 498. https:// doi.org/10.1186/s12967-022-03695-y
Liu, Y., Zheng, S., Cui, J., Guo, T., & Zhang, J. (2022b). Lactiplantibacillus Plantarum Y15 Alleviate Type 2 Diabetes in Mice via Modulating Gut Microbiota and Regulating NF-Κb and Insulin Signaling Pathway. Brazilian Journal of Microbiology, 53(2), 935–945. https://doi.org/10. 1007/s42770-022-00686-5
Mazloom, Z. (2013). Effect of Probiotics on Lipid Profile, Glycemic Control, Insulin Action, Oxidative Stress, and Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial. 38(1).
Mohammad Shahi, M., Veissi, M., Haidari, F., Shahbazian, H., Kaydani, G. A., & Mohammadi, F. (2014). Effects of Probiotic Yogurt Consumption on Inflammatory Biomarkers in Patients with Type 2 Diabetes [Text/html]. Biolmpacts; ISSN 2228-5652, 4(2). https://doi.org/10.5681/BI.2014.007
Naseri, K., Saadati, S., Ghaemi, F., Ashtary Larky, D., Asbaghi, O., Sadeghi, A., Afrisham, R., & de Courten, B. (2022). The Effects of Probiotic and Synbiotic Supplementation on Inflammation, Oxidative Stress, and Circulating Adiponectin and Leptin Concentration in Subjects with Prediabetes and Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review, Meta-Analysis, and Meta-Regression of Randomized Clinical Trials. European Journal of Nutrition. https://doi.org/10.1007/ s00394-022-03012-9
PintariÄ, M., & Langerholc, T. (2022). Probiotic Mechanisms Affecting Glucose Homeostasis: A Scoping Review. Life, 12(8), 1187. https://doi.org/10. 3390/life12081187
Putra, M. A. D., Suharti, N., & Anggraini, F. T. (2022). Peran Lactobacillus pada Diabetes Melitus Tipe 2. Jurnal Ilmu Kesehatan Indonesia, 3(1), 97–107. https://doi.org/10.25077/jikesi.v3i1.351
Razmpoosh, E., Javadi, A., Ejtahed, H. S., Mirmiran, P., Javadi, M., & Yousefinejad, A. (2019). The Effect of Probiotic Supplementation on Glycemic Control and Lipid Profile in Patients with Type 2 Diabetes: A Randomized Placebo Controlled Trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(1), 175–182. https://doi.org/10.1016/j. dsx.2018.08.008
Saha, S., Alam, N. N., & Rahman, S. M. N. (2021). The Role of Probiotic Supplementation on Insulin Resistance in Obesity-Associated Diabetes: A Mini-Review. MEDICINE & PHARMACOLOGY. https://doi.org/10. 20944/preprints202110.0134.v1
Saha, S., Rahman, S. M. N., & Alam, N. N. (2022). The role of probiotic supplementation on insulin resistance in obesity associated diabetes: A mini review. Biomedicine, 42(4), 651–656. https://doi.org/10.51248/. v42i4.1359
Salles, B. I. M., Cioffi, D., & Ferreira, S. R. G. (2020). Probiotics supplementation and insulin resistance: A systematic review. Diabetology & Metabolic Syndrome, 12(1), 98. https://doi.org/10.1186/s13098-020-00603-6
Shakeri, H., Hadaegh, H., Abedi, F., Tajabadi-Ebrahimi, M., Mazroii, N., Ghandi, Y., & Asemi, Z. (2014). Consumption of Synbiotic Bread Decreases Triacylglycerol and VLDL Levels While Increasing HDL Levels in Serum from Patients with Type-2 Diabetes. Lipids, 49(7), 695–701. https://doi.org/10.1007/s11745-014-3901-z
Å ola, K. F., Vladimir Knežević, S., HrabaÄ, P., Mucalo, I., Saso, L., & Verbanac, D. (2022). The effect of multistrain probiotics on functional constipation in the elderly: A randomized controlled trial. European Journal of Clinical Nutrition, 76(12), 1675–1681. https://doi.org/10.1038/s41430-022-01189-0
Souza, M. P. G., Mendes, R. C. M., Reis, D. M. dos, & Martins, M. Y. P. T. (2022). O efeito do uso de probióticos sobre glicemia de jejum, resistência à insulina e hemoglobina glicada em pessoas com Diabetes mellitus tipo 2: Uma revisão de literatura. Research, Society and Development, 11(5), e10411527972. https://doi.org/10.33448/rsd-v11i5.27972
Tao, Y. W., Gu, Y. L., Mao, X.Q., Zhang, L., & Pei, Y. F. (2020). Effects of probiotics on type II diabetes mellitus: A meta-analysis. Journal of Translational Medicine, 18(1), 30. https://doi.org/10.1186/s12967-020-02213-2
Tonucci, L. B., Olbrich dos Santos, K. M., Licursi de Oliveira, L., Rocha Ribeiro, S. M., & Duarte Martino, H. S. (2017). Clinical application of probiotics in type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled study. Clinical Nutrition, 36(1), 85–92. https://doi.org/10.1016/j.clnu. 2015.11.011
Wang, X., Yang, J., Qiu, X., Wen, Q., Liu, M., Zhou, D., & Chen, Q. (2021). Probiotics, Pre-biotics and Synbiotics in the Treatment of Pre-diabetes: A Systematic Review of Randomized Controlled Trials. Frontiers in Public Health, 9, 645035. https://doi.org/10.3389/fpubh.2021.645035
Wigati, L. I., Zuraida, R., & Fiana, D. N. (2022). Potensi Probiotik dalam Mikrobiota Usus sebagai Target Pengobatan Diabetes Mellitus. Diabetes Mellitus, 9(2).
Zhai, L., Wu, J., Lam, Y. Y., Kwan, H. Y., Bian, Z. X., & Wong, H. L. X. (2021). Gut Microbial Metabolites, Probiotics and Their Roles in Type 2 Diabetes. International Journal of Molecular Sciences, 22(23), 12846. https://doi. org/10.3390/ijms222312846
Zhang, Q., Wu, Y., & Fei, X. (2016). Effect of Probiotics on Glucose Metabolism in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials. Medicina, 52(1), 28–34. https://doi.org/10. 1016/j.medici.2015.11.008
Zhang, X., Zhang, Y., Luo, L., Le, Y., Li, Y., Yuan, F., Wu, Y., & Xu, P. (2023). The Beneficial Effects of a Multispecies Probiotic Supplement on Glycaemic Control and Metabolic Profile in Adults with Type 1 Diabetes: A Randomised, Double-Blinded, Placebo-Controlled Pilot-Study. Diabetes, Metabolic Syndrome and Obesity, Volume 16, 829–840. https://doi.org/10.2147/DMSO.S400119
Published
2023-06-20
Section
Articles
