Hepatoprotektif Ekstrak Batang Bajakah (Spatholobus littoralis Hassk) Induksi Tetraclorida (CCL4)

  • Mustika Sari IKIP PGRI Pontianak
  • Nawawi Nawawi IKIP PGRI Pontianak

Abstract

This study aims to explore the benefits of bajakah (Spatholobus littoralis Hassk) through the study of its utilization as a hepatoprotector. This research method is quantitative. Bajakah stem extract was made using 96% ethanol solvent using the maceration method. Analysis was carried out using liver histology preparations to determine the HAI (Histology Activity Index) Knodel Score. The treatment group consisted of 5 groups, namely, a) negative control (K1) treated with toxic doses of CCL4; b) positive control, namely vitamin E 46.8 mg/KgBW; c) P1 (treatment 1) was 750 mg/KgBW of Bajakah stem extract; d) P2 (treatment two) was 1200 mg/KgBW of pirated stem extract; e) P3 (treatment of three) was extract of the stem of Bajakah 1500 mg/KgBB. The results showed that the post hoc LSD test results in the P1 group had a histopathological picture of damaged liver, there was a significant difference with the K and P3 groups (p <0.05), but there was no significant difference when compared with the P2 group. Meanwhile, the P3 group had significant differences when compared to all groups (p <0.05). In conclusion, the administration of extract of pirated stems at a dose of 1,500 mg/Kg has a significant effect on the HAI value on the average number of hepatocytes with parenchymatous degeneration and necrosis after CCL4 induced

Keywords: Bajakah, CCL4, Hepatoprotective

 

References

Ahn, T. H., Yang, Y. S., Lee, J. C., Moon, C. J., Kim, S. H., Jun, W., Park, S.C., & Kim, J.C. (2007). Ameliorative Effects of Pycnogenol on Carbon Tetrachloride-Induced Hepatic Oxidative Damage in Rats. Phytother Res, 21, 1015–1019.

Anshari, I. (2012). Isolasi dan Identifikasi Senyawa Kimia Fraksi Etil Asetat Batang Bajakah Tampala (Spatholobus littoralis Hassk) Asal Kalimantan Tengah. Skripsi. Universitas Lambung Mangkurat, Banjar Baru

Ayuchecaria, N., Saputera, M. M. A., & Niah, R. (2020). Penetapan Kadar Fenolik Total Ekstrak Batang Bajakah Tampala (Spatholobus littoralis Hassk.) Menggunakan UV-Visibel. Jurnal Insan Farmasi Indonesia, 3(1), 132–141.

Azarmehr, A., Parisa, A. A, Mona, M. B., Heibatollah, S. C., Hossein, S. C., Behnam, A. C., Bahman, K. C., Zahra, B. A., Colovic, M. B., Krstic, T. D., Lazarevic-Pasti, A. M., Bondzic, B., & Vasic, V. M. (2013). Acetylcholinesterase Inhibitors: Pharmacology andToxicology. Current Neuropharmacology, 11(3), 315–335.

Brautbar, N., & Williams, J. (2002). 2nd Industrial Solvents and Liver Toxicity: Risk Assessment, Risk Factors and Mechanisms. Int. J. Hyg. Environ. Health, 205, 479–491.

Dragomir, R. S., Mishin, L. B., Hall, J. D., & Laskin, D. L. (2012). Role of Galectin-3 in Acetaminophen-Induced Hepatotoxicity and inflammatory Mediator Production. Toxicol. Sci. 127, 609–619.

Fitriani, E. S., & Saputra, S. H. (2020). Karakteristik Tanaman Akar Bajakah (Spatholobus littoralis Hassk) dari Loakulu Kabupaten Kutai Kartanegara. Jurnal Riset Teknologi Industri Hutan, 14(2), 365-376.

Hariana, A. (2013). Tumbuhan Obat dan Khasiatnya. Jakarta: Penebar Swadaya

Istiqomah, I., & Safitri, D. (2021). Phrmacological Activities of Spatholobus littoralis. Jurnal Info Kesehatan, 11(2),

Karatoprak, S. (2021). Chapter 12-Antioxidants with Hepatoprotective Activity. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases, 1, 209-225.

Kurnianto, K., Pangkahila, W., & Susraini, S. (2020) Administration of Bajakah (Spatholobus Littoralis Hassk) Stem Ethanol Extract Increased the Number of Leydig Cells and Testosterone Levels in Male Wistar Rats (Rattus Norvegicus) with Excessive Swimming Activity Monika Indriani. International Journal of Science And Research (IJSR), 9(12), 234-241

Ma, A. X. Y., Chayanis, S. B., Xiao-Die, L. A., Qian, M. A., Xin, W. A., Shen, J. C., Ya-Jun, C. (2020). Combined Application of Extended Depth of Field Imaging, Image Stitching and Polarized Microscopy Techniques in Identification of Spatholobus suberectus. Chinese Herbal Medicines, 12, 367–374

Mahardika, G. D., Dewi, N. W. S., & Aman, A. (2020). Ekstrak Etanol Daun Sambiloto (Andrographis paniculata) Menurunkan Hai (Histology Activity Indeks)-Knodell Score Pada Hepar Mencit (Mus musculus) Jantan yang Diinduksi Ccl4. Jurnal Medika Udayana, 9(4), 75-80

Maulina, S., Pratiwi, D. R., & Erwin. (2019). Skrining Fitokimia dan Bioaktivitas Ektrsak Akar Uncaria nervosa elmer (Bajakah). Jurnal Atomik, 4(2), 100–102.

Oriakhi, B., & Ojeaburu, O. (2021). Hepatoprotective, Antioxidant and, Anti-Inflammatory Potentials of Gallic Acid in Carbon Tetrachloride-Induced Hepatic Damage in Wistar Rats. Toxicology Reports, 8, 177–185.

Saputera, M. M. A., & Ayuchecaria, N. (2018). Uji Efektivitas Ekstrak Etanolik Batang Bajakah (Spatholobus littoralis Hassk.) terhadap Waktu Penyembuhan Luka. Journal of Chemical Information and Modeling, 53(9), 1689–1699.
Published
2023-09-08
Abstract viewed = 22 times
pdf downloaded = 37 times