BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains is published by research institute of mathematics, computer, nursering, education and economics (IPM2KPE) as the information and communication media for practitioners, researchers and academics who engaged, put interest and fully attention on biology education and science.BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains publishes articles both in online/OJS (e-ISSN 2598-7453) and printed (p-ISSN 2622-3929 versions.
Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)
Pengembangan Media Leaflet Berbasis SSI (Socio-Scientific Issues) Sebagai Media Pembelajaran Siswa SMA pada Materi Sistem Peredaran Darah di Kelas XI
This study aimed to Develop an instructional medium in the form of a leaflet based on Socio-Scientific Issues (SSI) for the Human Circulatory System topic in Grade XI senior high school students. The Development process employed the 4D model (Define, Design, Develop, and Disseminate). The Define stage involved a needs analysis through interviews and observations, revealing that learning remained textbook-centered and lacked connections to social issues. The Design stage produced a tri-fold leaflet featuring communicative language and supporting illustrations. The product was then validated by media and material experts during the Develop stage and subsequently tested on students. The results show that media and material validation scores were both 90% (categorized as highly feasible). Teacher responses reached 90.76%, and student responses reached 85%, indicating that the leaflet is attractive, easy to use, and supports conceptual understanding. Furthermore, students' learning interest increased, with an average score of 95.44% (very high category). In conclusion, the SSI-based leaflet is considered practical, effective, and feasible to be used as a teaching material that supports contextual and meaningful biology learning. Keywords: Leaflet, Learning Interest, Learning Media, SSI (Socio-Scientific Issues)
Copyright (c) 2025 Anggita Anggeraini Harahap, Efrida Pima Sari Tambunan http://creativecommons.org/licenses/by-nc/4.0
Pengembangan Komik Edukatif Sebagai Media Pembelajaran Siswa untuk Meningkatkan Kemampuan Pemecahan Masalah pada Materi Reproduksi Manusia
This study aims to develop an educational comic titled “Masa Pubertas: Menjelajahi Sistem Reproduksi” as a Biology learning medium on the topic of the human reproductive system to enhance students’ problem-solving skills. The research employed the ADDIE development model, which consists of the analysis, design, development, implementation, and evaluation stages. Data were collected through interviews, observations, questionnaires, as well as pretests and posttests, and were analyzed using descriptive qualitative and quantitative approaches. The results indicate that the educational comic is highly valid based on expert assessments, highly practical according to teachers and students, and effective in improving learning outcomes. In conclusion, the educational comic is feasible to be used as an innovative learning medium and has the potential to be further developed for other Biology topics. Keywords: ADDIE, Problem-Solving Skills, Learning Media, Educational Comic, Human Reproductive System
Copyright (c) 2025 Balqis Putri Wardana Purba, Khairuna http://creativecommons.org/licenses/by-nc/4.0
Efektivitas Pemberian Pakan Ikan Red Devil (Amphilophus sp.) sebagai Pakan Alternatif terhadap Pertumbuhan Morfometrik dan Bobot Badan Ikan Patin (Pangasius sp.)
This study aimed to determine the effectiveness of Red Devil fish (Amphilophus sp.) as an alternative feed on the morphometric growth and body weight of catfish (Pangasius sp.). The method used was a completely randomized design (CRD) consisting of five feed treatments, each replicated four times, resulting in 20 experimental units. The treatments included: (a) P0: 100% commercial feed, (b) P1: 100% Red Devil feed, (c) P2: 75% commercial feed + 25% Red Devil feed, (d) P3: 50% commercial feed + 50% Red Devil feed, and (e) P4: 25% commercial feed + 75% Red Devil feed. Data were analyzed using ANOVA followed by Duncan’s test at a 5% significance level. The results showed that all five treatments significantly affected the morphometric growth and body weight of catfish. The highest performance was obtained in P1 (100% Red Devil feed), which produced a head length of 2.72 cm, tail length of 1.70 cm, total length of 10.25 cm, and an absolute length growth of 3.12 cm. The body weight reached 9.49 g with a specific growth rate (SGR) of 0.180. Keywords: Alternative, Feed, Morphometric, Pangasius, Red Devil
Copyright (c) 2025 Muhammad Reza Batubara, Efrida Pima Sari Tambunan http://creativecommons.org/licenses/by-nc/4.0
Pemberian Jus Buah (Etlingera hemisphaerica) terhadap Pemulihan Eritrosit dan Leukosit Akibat Perlakuan Merkuri Klorida (HgCl2) pada Mencit (Mus musculus)
This study aims to determine the effect of Etlingera hemisphaerica (honje) fruit juice on the recovery of erythrocyte and leukocyte counts in mice (Mus musculus) exposed to mercuric chloride (HgCl₂). The method used was an experimental design using male mice as test animals, divided into three groups: K1 (control), K2 (honje juice 0.3 mL/20 g BW for 3 days), and K3 (HgCl₂ 5 mg/kg BW + honje juice 0.3 mL/20 g BW for 3 days). The observed parameters were the number of erythrocytes and leukocytes before and after treatment. The results showed that honje juice administration increased the erythrocyte count in group K2, while in group K3, erythrocyte recovery was affected by mercury exposure, making the honje juice less effective, although the values remained within the normal range compared to the control group. In leukocyte count, group K2 showed a stabilizing effect, whereas group K3 experienced an increase due to HgCl₂ exposure. In conclusion, Etlingera hemisphaerica fruit juice has potential as a phytotherapy agent to repair hematological damage caused by heavy metal toxicity, although its effectiveness is influenced by the metabolic condition of the mice and the high concentration of mercury. Keywords: Etlingera hemisphaerica, Erythrocytes, Leukocytes, Mice, Mercuric Chloride
Copyright (c) 2025 Fatimah Azzahrah, Aceng Ruyani, Deni Parlindungan, Arsela Eko Listiono, Afrizal Mayub http://creativecommons.org/licenses/by-nc/4.0
Analisis Representasi Aspek Sustainable Development Goals (SDGs) pada Buku Teks IPA SMP di Kota Medan
This study aims to examine how the Sustainable Development Goals (SDGs) are presented in science textbooks used by seventh-grade junior high school students in Medan. The method employed was content analysis of two science textbooks published by the Ministry of Education and Yudhistira. The study focused on six SDG targets: Goals 2, 3, 6, 13, 14, and 15. The results show that the presentation of SDGs in the textbooks varies in clarity, quantity, quality, and context. Environmental aspects (SDGs 13, 14, and 15) appear more frequently than social and economic aspects (SDGs 2, 3, and 6), which tend to appear indirectly. Overall, the integration of SDGs in the textbooks does not fully reflect the principles of Education for Sustainable Development (ESD), as the content primarily emphasizes cognitive components rather than practical skills, attitudes, and actions. These findings highlight the importance of science textbooks in supporting sustainable education through curriculum updates, enhancement of ESD competencies, and the development of evaluation systems aligned with SDG achievement. Keywords: Content analysis, Sustainable Development Goals (SDGs) aspects, Science textbooks
Copyright (c) 2025 Dini Indah Syahfitri, Ummi Nur Afinni Dwi Jayanti http://creativecommons.org/licenses/by-nc/4.0
Pengembangan E-LKPD Berbasis Problem Based Learning (PBL) dengan Aplikasi Liveworktsheet pada Materi Sistem Imunitas untuk Meningkatkan Kemampuan Berfikir Kritis Siswa SMA
The research was conducted with the aim of developing an E-LKPD learning product based on Problem Based Learning (PBL) integrated with the Liveworksheet platform on the immune system material, as an effort to develop students' critical thinking skills, this research used the Research and Development (R&D) method by adapting the ADDIE model. The model consists of five main stages, namely analysis, design, development, implementation, and evaluation, which are carried out systematically to produce valid, practical, and effective learning products. The instruments used consisted of expert validation sheets, teacher and student response questionnaires, and problem-solving ability tests through pretest and posttest. The results of the study showed that the resulting E-LKPD product was classified as very valid with a validation score of 91%, had a very high level of practicality with a score of 90% from teachers and 94% from students, and showed high effectiveness with an N-Gain value of 0.76. In conclusion, E-LKPD based on Problem Based Learning (PBL) developed through Liveworksheet is suitable for use as a biology learning medium for the immune system material because it has been proven to be valid, practical, and effective in improving students' critical thinking skills. Keywords: Critical Thinking, E-LKPD, Liveworksheet, PBL, Immune System
Copyright (c) 2025 Nayla Nayla, Syarifah Widya Ulfa http://creativecommons.org/licenses/by-nc/4.0
Pengembangan LKPD Berbasis Contextual Teaching and Learning untuk Meningkatkan Keterampilan Berpikir Kritis Siswa Pada Materi Sistem Gerak
This study aims to develop a student worksheet (Lembar Kerja Peserta Didik or LKPD) based on Contextual Teaching and Learning that is valid, practical, and effective for students. The research method employed was research and development, with instruments consisting of teacher and student needs questionnaires, material and media validation sheets, practicality sheets, as well as effectiveness sheets through pretests and posttests. Data analysis included validity, practicality, and effectiveness tests. The results indicated that the developed LKPD demonstrated high validity, was practical for both teachers and students, and was effective in enhancing students’ critical thinking skills. In conclusion, the LKPD based on Contextual Teaching and Learning can serve as appropriate teaching material to foster critical thinking skills in biology concepts. Keywords: Critical Thinking, Contextual Teaching And Learning, Development
Copyright (c) 2025 Adella Shaharani, Kartika Manalu http://creativecommons.org/licenses/by-nc/4.0
Morfologi dan Morfometri Pomacea canaliculata (Gastropoda: Ampullariidae) di Kecamatan Tulangan, Kabupaten Sidoarjo
This study aims to describe the presence of Pomacea canaliculata in Tulangan District, Sidoarjo Regency, and to identify its morphological and morphometric characteristics. The method used was purposive sampling, with specimens collected from three different locations: Saman Hudi River, Kepatihan Village rice fields, and Kenongo Village rice fields. Morphological observations included shell coiling direction, shell shape and color, aperture shape, umbilicus type, and operculum type. Morphometric measurements covered shell height and width, tentacle length, body whorl height, and aperture height and width. The results showed that Pomacea canaliculata shells are round, with yellowish-brown to dark brown coloration and spiral line patterns following the coiling direction. The aperture is oval to elongated crescent-shaped, slightly widened at the base, with a slit-type umbilicus, and a corneous operculum with concentric rings and a subcentral nucleus. Based on morphometric analysis using Principal Component Analysis (PCA), the largest Pomacea canaliculata individuals were found in Kepatihan Village rice fields, while the smallest were found in Saman Hudi River. Differences in morphology and morphometry among locations indicate significant environmental influences, including habitat conditions and natural selection. Keywords: Ampullariidae, Agricultural Ecosystem, Habitat, Invasive, Characteristics
Copyright (c) 2025 Dewi Hanuninda, Reni Ambarwati, Dwi Anggorowati Rahayu http://creativecommons.org/licenses/by-nc/4.0
Keanekaragaman Gastropoda di Sungai Gembolo, Kecamatan Pungging, Kabupaten Mojokerto
This study aims to identify the gastropod diversity in the Gembolo River, Pungging District, Mojokerto Regency. The sampling method used was manual collection (hand picking) at three observation stations, and species identification was conducted based on morphological characteristics. The results showed that five gastropod species belonging to four families were found in the Gembolo River. The diversity index value of 1.06 indicates a moderate level of diversity. The dominance index value of 0.42 suggests that no single species dominates the gastropod community. In conclusion, the gastropod diversity in the Gembolo River is categorized as moderate, with no dominant species observed. Keywords: Biodiversity, Gastropods, Freshwater Snails, Morphometry
Copyright (c) 2025 Nafilah Zerlita Fahrani, Reni Ambarwati, Dwi Anggorowati Rahayu http://creativecommons.org/licenses/by-nc/4.0
Eksplorasi Potensi Actinomycetes Penghasil Antibiotik Baru dari Danau Poso Sulawesi Tengah Sebagai Antibakteri Patogen pada Manusia
This study aims to isolate, characterize, evaluate antibacterial activity, and identify Actinomycetes isolates at the molecular level. The method used was an experimental approach with a descriptive design. The research consisted of several stages: (1) isolation and characterization through macroscopic, microscopic, and biochemical tests, and (2) antibacterial activity testing and molecular identification of Actinomycetes isolates. The results showed that five isolates—DP1, DP2, DP3, DP4, and DP5—were identified and suspected to belong to the genus Streptomyces. Macroscopic and microscopic characterization indicated that all isolates exhibited white, yellow, and brown colony colors and were Gram-positive. Biochemical tests showed positive results for catalase, coagulase, oxidase, citrate, and TSIA tests. Antibacterial activity assays against Escherichia coli and S. aureusrevealed that isolate DP4 had the strongest inhibition zone, while showing negative activity against S. typhi. In conclusion, five Actinomycetes isolates were successfully isolated from the sediment soil of Lake Poso. Isolate DP4 demonstrated the greatest potential as an antibacterial candidate by inhibiting two pathogenic bacteria. Based on 16S rDNA sequence similarity analysis, isolate DP4 was identified as S. aurantiacus with 99% similarity. Keywords: Actinomycetes, Antibacterial, Lake Poso, Exploration
Copyright (c) 2025 Hermin Lastri Gintoe, Riskayati, Slamet Ifandi , Andi Lindhemutianingrum Siradje http://creativecommons.org/licenses/by-nc/4.0
Pengembangan E-Modul Berbasis Socio Scientific Inquiry Based Learning (SSIBL) pada Materi Sistem Pencernaan
This study aims to develop a Socio Scientific Inquiry Based Learning (SSIBL)-based e-module on the digestive system topic that is valid, practical, and effective for use in biology learning. The method used was Research and Development (R&D) employing the 4D model, which includes the stages of define, design, develop, and disseminate. The research subjects consisted of 30 students from grade XI Science at a private Islamic senior high school (Madrasah Aliyah Swasta) and one biology teacher. The research instruments included validation sheets, teacher and student response questionnaires, and learning achievement tests. The results showed that the e-module was highly valid with a percentage of 95.83% (content) and 91.67% (media). Teacher responses reached 98.07%, and student responses reached 93.80%, both categorized as very practical. The effectiveness test obtained a score of 0.71, classified as high, indicating that the e-module was effective in improving students’ learning outcomes. In conclusion, the SSIBL-base e-module is feasible to be used as an alternative digital teaching material for the digestive system topic. This e-module not only facilitates students’ understanding of biology but also enhances their awareness of health issues and their ability to make wise decisions in everyday life. Keywords: Biology, E-Module, Learning Outcomes, SSIBL, Digestive System.
Copyright (c) 2025 Safitri Safitri, Miza Nina Adlini http://creativecommons.org/licenses/by-nc/4.0
Efektivitas Model Pembelajaran Berbasis Proyek Terhadap Kemampuan Kolaborasi dan Literasi Lingkungan Siswa SMP pada Materi Ekosistem
This study aims to examine the effectiveness of the project-based learning (PjBL) model in improving students’ collaboration skills and environmental literacy in ecosystem topics. The method used was a quasi-experimental design with a one-group pretest-posttest involving 32 seventh-grade students at SMP Negeri 2 Perbaungan. Research instruments consisted of observation sheets and an environmental literacy test that had been validated and tested for reliability. The results indicate that the implementation of PjBL successfully enhanced students’ collaboration skills and environmental literacy in cognitive, affective, and behavioral aspects. In conclusion, project-based learning is effective in developing collaboration and environmental literacy, as well as fostering students’ awareness and responsibility toward the environment. Keywords: Collaboration, Environmental Literacy, Project-Based Learning
Copyright (c) 2025 Isnaini Rahmah Lubis, Ummi Nur Afinni Dwi Jayanti http://creativecommons.org/licenses/by-nc/4.0
Meningkatkan Hasil Belajar Sistem Pernapasan Manusia Melalui Video Based E-Learning Youtube Siswa Kelas VIII SMP Kartika IV-6 Ambulu Tahun Ajaran 2024/2025
This study aims to improve student activity and learning outcomes in the human respiratory system through the application of a YouTube-based Video Based Learning (VBL) model. The research method used was Classroom Action Research (CAR), conducted in grade VIII of SMP Kartika IV-6 Ambulu in the 2024/2025 academic year with 18 students. The study was conducted in two cycles, each consisting of planning, implementation, observation, and reflection. Data were collected through observations of student activity and cognitive learning test items. The results showed an increase in both student activity and learning outcomes from cycle I to cycle II. In cycle I, the average student score was 68.72 with a classical completion rate of 44.44%. In cycle II, the average score increased to 85.88 with a classical completion rate of 88.88%. Furthermore, student activity also increased from moderately active to very active. In conclusion, the use of YouTube-based learning videos has proven effective in increasing student motivation, activeness, and learning outcomes in the human respiratory system. Keywords: Student Activities, Learning Outcomes, Video Based Learning, YouTube
Copyright (c) 2025 Viona Rizki Romadona, Waris , Ismul Maulidin Al Habib http://creativecommons.org/licenses/by-nc/4.0
Pengembangan E-Modul Berbasis Team Games Tournament (TGT) Terhadap Kemampuan Berpikir Kritis pada Materi Sistem Pencernaan Manusia Kelas XI
This study aims to develop a Team Games Tournament (TGT)-based e-module on the human digestive system for 11th-grade high school students to enhance their critical thinking skills. The research employed a Research and Development (R&D) approach using the ADDIE model (Analysis, Design, Development, Implementation, Evaluation). The participants were 11th-grade students at SMA Negeri 16 Medan. Data were collected using expert validation sheets, teacher and student response questionnaires, and pretest–posttest assessments. The results indicated that the e-module was classified as highly valid (92% by content experts and 91% by media experts). The practicality test showed very high practicality scores from both teachers (97.75%) and students (94%). Furthermore, the effectiveness test, measured by an N-gain of 0.80, demonstrated a significant improvement in students’ learning outcomes. In conclusion, the developed TGT-based e-module is valid, practical, and effective in enhancing students’ critical thinking skills in the study of the human digestive system. Keywords: ADDIE, Critical Thinking, E-module, Human Digestive System, Team Games Tournament
Copyright (c) 2025 Ardilla Sari, Syarifah Widya Ulfa http://creativecommons.org/licenses/by-nc/4.0
Pengembangan Media Pembelajaran Berbasis Game Edukasi Digital pada Materi Sistem Reproduksi untuk Meningkatkan Kemampuan HOTS pada Siswa SMA/MA
This study aims to develop a digital educational Game-based learning medium on the human reproductive system material to enhance students’ Higher Order Thinking Skills (HOTS). The research method employed the ADDIE development model, which includes the stages of analysis, design, development, implementation, and evaluation. The research subjects were high school students studying the reproductive system. Data were collected through expert validation questionnaires, classroom observations, and tests to measure the improvement of students’ HOTS. The results showed that the developed digital educational Game has a high level of feasibility based on assessments from material and media experts. Its classroom implementation demonstrated improvements in students’ HOTS, particularly in the aspects of analysis, evaluation, and creation. In conclusion, this medium is effective as an innovative and interactive biology learning alternative that stimulates higher-order thinking skills. Keywords: Digital Educational Game, HOTS, Human Reproductive System
Copyright (c) 2025 Jelita Purnama Sari, Rasyidah http://creativecommons.org/licenses/by-nc/4.0
Pengembangan Media Pembelajaran Leap Motion Materi Pengenalan Hewan untuk Meningkatkan Motorik Anak Usia Dini
This study aims to develop an interactive learning medium based on Leap Motion, namely LeapZoo: Zoo-Based Educational Game, which is designed to improve early childhood motor skills through virtual animal recognition. The method used was research and development (R&D) with the ADDIE model, focusing on the design and development stages. Validation was carried out by media, language, and early childhood education experts to assess technical and pedagogical feasibility. The results showed that LeapZoo is feasible to be used as a learning medium in early childhood education. In conclusion, gesture-based interactions such as stroking and feeding animals can stimulate children’s fine and gross motor coordination and align with Vygotsky’s theory, which emphasizes the role of social interaction and digital scaffolding in the zone of proximal development. Keywords: Early Childhood, Gesture-Based Learning, Leap Motion, Learning Media, Motor Skills, Animal Recognition
Copyright (c) 2025 Esti Kurniawati Mahardika, Gunawan Wiradharma, Mario Aditya Prasetyo, Khaerul Anam, Muktia Pramitasari http://creativecommons.org/licenses/by-nc/4.0
Efek Anti-Hiperurisemia Kombinasi Ekstrak Eleutherine bulbosa dan Zingiber officinale pada Mencit Hiperurisemia
This study aimed to evaluate the effectiveness of the combined extracts of Eleutherine bulbosa and Zingiber officinale as an antihyperuricemic therapy in mice. The research employed a post-test only control group design with seven treatment groups, consisting of a negative control, a positive control (allopurinol), and five groups receiving different doses and ratios of the combined extracts. Uric acid levels were analyzed using a one-way ANOVA followed by Duncan’s multiple range test at a 5% significance level. The results showed that the combined extracts significantly reduced uric acid levels compared to the negative control, although no significant differences were observed among the combination groups. The combination dose of 300 mg/kg body weight with a 1:2 ratio produced a reduction in uric acid levels most comparable to the positive control. In conclusion, the combination of E. bulbosa and Z. officinale shows potential as an antihyperuricemic agent; however, further studies are required to explore the cellular mechanisms, pharmacokinetics, and related gene expression involved. Keywords: Eleutherine bulbosa, Hyperurisemia,Combination of Extracts, Zingiber officinale
Copyright (c) 2025 Rafli Bilal Firdizky, Noor Hujjatusnaini, Lilin Ika Nurindahsari http://creativecommons.org/licenses/by-nc/4.0
Paradigma Pembangunan Berkelanjutan Sosial, Ekonomi dan Ekologi: Studi Keberlanjutan Ecovillage Das Citarum
This study aims to identify the elements influencing the sustainability of ecovillage development in 49 villages located in the Citarum Watershed. The method used was qualitative, through field observation, interviews, and data and information collection. Prospective analysis results show that in the Ecological Dimension, there are four main influencing elements: (1) utilization of agricultural waste; (2) disposal of agricultural waste; (3) fertilization techniques; and (4) conservation activities. In the Economic Dimension, three main elements were identified: (1) community support in selling recycled products; (2) community support in creating employment; and (3) development of post-harvest household production. In the Social Dimension, four main elements were found: (1) support from local government; (2) joint commitment of all stakeholders; (3) institutions emphasizing support for environmental programs; and (4) community involvement. In conclusion, the sustainability of ecovillage development in the Citarum Watershed is influenced by four key elements: support from local government, joint agreement among all stakeholders, institutions emphasizing support for environmental programs, and community involvement in environmental activities, with three strategic plans: pessimistic, moderate, and optimistic. Keywords: Citarum Hulu, Ecovillage, Environment, Sustainability, Watershed
Copyright (c) 2025 A Hadian Pratama Hamzah, Nurhasanah, Sohifah http://creativecommons.org/licenses/by-nc/4.0
Pengembangan Flashcard Berbasis Pendekatan Saintifik: Media Pembelajaran pada Materi Struktur dan Fungsi Sel
The purpose of this study was to develop flashcards based on a scientific approach to the material of cell structure and function in order to improve student learning outcomes. The background of this research is the low interest of students in participating in learning due to the lack of interactive learning media which has an impact on low student learning outcomes. The research method used is R&D (Research and Development) research with the ADDIE model which has 5 stages, namely analysis, design, development, implementation and evaluation. The subjects in this study were 22 students of class XI IPA 2 at SMA Swasta Sinar Husni. Flashcards were validated by material experts and media experts and tested for practicality and effectiveness. The results showed that flashcards obtained a percentage of material validity of 84% (very valid) and media validity of 94% (very valid). Flashcards were also declared practical with a percentage of 93% (very practical) from teachers and 84% (very practical) from students. The effectiveness test with an N-Gain score of 0.88 (High) showed that there was a significant increase in student learning outcomes. In conclusion, flashcards based on a scientific approach to cell structure and function material can be declared valid, practical and effective and have the potential to support active learning in biology learning. Keywords: Flashcard, Scientific Approach, Cell Structure and Function
Copyright (c) 2025 Izza Yani Umaroh, Miza Nina Adlini http://creativecommons.org/licenses/by-nc/4.0
E-Magazine Berbasis Discovery Learning Terintegrasi Ayat Al-Qur’an: Pengembangan Media Pembelajaran Biologi pada Sistem Pernapasan
This study aims to develop a learning medium in the form of an e-magazine based on Discovery Learning integrated with Qur’anic verses, as well as to examine its validity, practicality, and effectiveness in improving students’ learning outcomes on the respiratory system material for Grade XI. The method used was Research and Development (R&D) with the ADDIE model. The instruments used in this study included interview sheets and questionnaires. The results showed that validation by material, media, and Qur’anic integration experts indicated that the e-magazine was in the “very valid” category for use in learning, with a score of 97%. Students’ responses to the medium were categorized as “very practical” with a score of 91%, as were teachers’ responses with a score of 97%. Effectiveness testing showed an N-Gain value of 0.65, which falls into the “medium” category (moderately effective), indicating an improvement in learning outcomes after using the medium. In conclusion, this e-magazine is considered feasible and moderately effective for use as a biology learning medium, not only strengthening conceptual understanding but also instilling spiritual values through the integration of Qur’anic verses. Keywords: ADDIE, Qur’anic Verses, Discovery Learning, E-magazine
Copyright (c) 2025 Afifa Zahra Simanungkalit, Miza Nina Adlini http://creativecommons.org/licenses/by-nc/4.0
Efektivitas Penambahan Auksin (IBA) dan Sitokinin (BAP) Terhadap Sambung Pucuk (Grafting) pada Pertumbuhan Vegetatif Tanaman Alpukat (Persea Americana)
This study aimed to determine the effectiveness of auxin (IBA) and cytokinin (BAP) application on avocado (Persea americana) in improving grafting success. The method used was a factorial randomized block design (RBD) of 3×3 with three replications. The observed parameters included the percentage of graft survival, time to bud emergence, number of buds, bud length, and number of leaves. The results showed that the application of IBA and BAP significantly affected the time to bud emergence and bud length, but had no significant effect on the percentage of graft survival, number of buds, and number of leaves. In conclusion, growth hormones can accelerate the initial physiological response in grafting, although they do not always impact overall vegetative growth. Keywords: Avocado, BAP, Grafting, IBA, Persea americana
Copyright (c) 2025 Rafika Nasution, Rahmadina http://creativecommons.org/licenses/by-nc/4.0
Analisis Network Pharmacology Senyawa Metabolit Sekunder Tumbuhan Benalu Kopi (Loranthus ferrugineus Roxb.ex Jack Danser) pada Penyakit Kanker Payudara
This study aims to evaluate the potential of coffee bean metabolite compounds as breast anticancer agents through a network pharmacology approach. The method used starts from literature study and PubChem database. Selection of compound eligibility was carried out with SwissADME using Lipinski's Rule of Five criteria. Protein target prediction was done through SwissTargetPrediction, while breast cancer target data was obtained from GeneCards and OMIM. Protein-protein interactions were analyzed with STRING and visualized using Cytoscape. Compound-protein interactions were analyzed through STITCH. The results showed that nine metabolite compounds from coffee bean met the pharmacokinetic criteria, with five main compounds showing anticancer potential is quercetin, oleic acid, linoleic acid, GCG, and PPARA. Protein interaction network analysis identified five central target proteins: IL6, TNF, AKT1, PTGS2, and ESR1. The compound-protein interactions suggest multitarget potential in the modulation of breast cancer-related molecular pathways. Keywords: Breast Cancer, Loranthus ferrugineus, Network Pharmacology
Copyright (c) 2025 Nur Aira Juwita, Wawan Sujarwo, Dinda Rizka Manurung http://creativecommons.org/licenses/by-nc/4.0
Pengembangan Modul Anatomi dan Fisiologi Tubuh Manusia Berbasis Case Method untuk Mahasiswa Jurusan Biologi
This research aims to develop and produce a case-based Human Anatomy and Physiology module that is suitable for use as a learning resource for students. This research is a research and development (R&D) study using the Five-Stage Level 1 model, with 84 Biology Education students, class of 2021, as the target subjects. Data collection techniques and instruments used were expert validation sheets and lecturer and student response questionnaires. The research data were analyzed using feasibility analysis techniques based on the feasibility of the material, design, language, and learning. The study concluded that the case-based Human Anatomy and Physiology module was deemed feasible based on assessments from material expert validators (4.35), design expert validators (4.00), and learning expert validators (4.29), and was deemed quite feasible based on assessments from language expert validators (3.78). The lecturers and students of the Biology Education Study Program generally gave good responses (4.36 and 4.14) to the case-based Human Anatomy and Physiology module. Keywords: Human Anatomy and Physiology, Case Method, Five-Stage Model, Module.
Copyright (c) 2025 Siti Aisyah Siti, Melva Silitonga, Syahmi Edi http://creativecommons.org/licenses/by-nc/4.0
Pengembangan Modul Pembelajaran Anatomi dan Fisiologi Manusia Berbasis Studi Kasus (Case Study) untuk Mahasiswa Prodi Pendidikan IPA UNIMED
This study aims to develop a case-based learning module on Human Anatomy and Physiology that is feasible for use by students of the Science Education Study Program at Universitas Negeri Medan (UNIMED). The research was conducted from January to June 2025 at the Faculty of Mathematics and Natural Sciences (FMIPA), UNIMED. The method used was research and development (R&D) with the MANTAP model level 1, which includes the stages of needs analysis, product development, and validation. The research subjects included lecturers of the Anatomy and Physiology course and students from the 2023 cohort of the Science Education Study Program at UNIMED. Data were collected through questionnaires and validation sheets, and analyzed both quantitatively and qualitatively. The results show that the developed module received an “excellent” rating from the subject matter expert (89.27), instructional design expert (92.25), and graphic design expert (86.80). It was also considered “highly practical” based on feedback from lecturers (92.16) and students, both in small groups (81.9) and larger groups (83.4). In conclusion, this case-based module is highly feasible and practical as a contextual teaching material to support the learning process of Science Education students at UNIMED. Keywords: Anatomy, Physiology, Module, Development, Case Study
Copyright (c) 2025 Sri Enita Ginting, Melva Silitonga, Martina Restuati http://creativecommons.org/licenses/by-nc/4.0
Pengembangan E-LKPD Berbasis Discovery Learning untuk Meningkatkan Kemampuan Analisis Siswa pada Materi Hormon dalam Reproduksi Manusia
This study aims to develop a Discovery Learning-based electronic student worksheet (e-LKPD) that is valid, practical, and effective in improving students' analytical skills on the topic of hormones in the human reproductive system. The method used in this study is research and development (R&D) by adapting the 4D model: define, design, develop, and disseminate. Research instruments included needs analysis, expert validation sheets, and teacher and student response questionnaires. The results show that the developed Discovery Learning-based e-LKPD meets the criteria of validity, practicality, and effectiveness. In conclusion, the e-LKPD is suitable to be used as a learning tool that facilitates the development of students' analytical skills. Keywords: Discovery Learning, E-LKPD, Analytical Skills
Copyright (c) 2025 Putri Agustina Anggreni Arwira, Efrida Pima Sari Tambunan http://creativecommons.org/licenses/by-nc/4.0
Pengembangan E-LKPD Berbasis PBL Terintegrasi AI pada Materi Klasifikasi Makhluk Hidup untuk Meningkatkan HOTS dan KPS
This study aims to develop and evaluate the feasibility and effectiveness of an Electronic Student Worksheet (E-LKPD) based on Problem-Based Learning (PBL) integrated with Artificial Intelligence (AI) on the topic of classification of living organisms, to enhance students’ Higher Order Thinking Skills (HOTS) and Science Process Skills (SPS). The research employed a Research and Development (R&D) method using the 4-D model (Define, Design, Develop, Disseminate). Effectiveness testing was conducted through a quasi-experimental design using a pretest-posttest control group. Data were analyzed using independent sample t-test and N-Gain analysis. The validation results indicated that the E-LKPD was in the “highly feasible” category. The t-test results for the pretest showed no significant difference between the experimental and control groups (t = 0.031; p = 0.975), while the posttest results revealed a significant difference (t = 7.403; p = 0.000). The N-Gain scores for HOTS and SPS were 0.61 and 0.68, respectively, both categorized as moderate and effective. It is concluded that the PBL-based E-LKPD integrated with AI is feasible and effective for improving students’ HOTS and SPS in biology learning. Keywords: AI, E-LKPD, HOTS, SPS, Problem Based Learning
Copyright (c) 2025 Eunike Manurung, Khairiza Lubis, Melva Silitonga http://creativecommons.org/licenses/by-nc/4.0
Pengaruh Pemberian Ekstrak Daun Salung (Psychotria viridiflora) terhadap Glukosa Darah Mencit (Mus musculus)
This study aimed to determine the effect of salung (Psychotria viridiflora) leaf extract on blood glucose levels in hyperglycemic mice (Mus musculus). A total of 25 mice weighing 20–40 grams were divided into five treatment groups: P1 (negative control: feed and distilled water), P2 (alloxan 10 mg/kg BW + glibenclamide 0.1 mg/kg BW), P3 (alloxan 10 mg/kg BW + P. viridiflora leaf extract 0.0112 g/kg BW), P4 (alloxan 10 mg/kg BW + P. viridiflora leaf extract 0.0225 g/kg BW), and P5 (alloxan 10 mg/kg BW + P. viridiflora leaf extract 0.0337 g/kg BW). Blood glucose levels were measured four times—on days 0, 6, 12, and 18—covering baseline measurement, post-alloxan induction, and after treatment administration. The results showed that the highest dose (0.0337 g/kg BW) was the most effective in reducing blood glucose levels in alloxan-induced mice, with an effect comparable to the standard drug glibenclamide. In conclusion, P. viridiflora leaf extract has potential as an alternative herbal antidiabetic therapy in M. musculus. Keywords: Antidiabetic, Blood Glucose, Extract Leaf, Hyperglycemia, Mus musculus, Psychotria viridiflora
Copyright (c) 2025 Niki Dwi Dia Dara, Aceng Ruyani, Rendy Wikrama Wardana, Afrizal Mayub, Bhakti Karyadi http://creativecommons.org/licenses/by-nc/4.0
Pengembangan Ensiklopedia Tumbuhan Obat Etnis Melayu Berbasis Literasi Sains di Kawasan Pesisir Timur Sumatra Utara sebagai Sumber BelajarMata Kuliah Etnobotani
This study aims to develop a scientific literacy-based ethnobotanical encyclopedia of medicinal plants of the Malay ethnic group in the Eastern Coastal region of North Sumatra and to determine the quality of the developed encyclopedia based on expert validation and user trials. The method used was Research and Development (R&D) adopting the ADDIE development model. Research instruments included validation sheets from material experts, instructional design experts, and layout design experts, as well as response questionnaires from ethnobotany course lecturers and students. The results showed that the developed encyclopedia received a validation score of 96.25% from instructional design experts, 89.7% from material experts, and 98.75% from layout design experts, all categorized as very valid. Lecturers’ responses indicated a practicality level of 89.73%, while student responses reached 94.23%, both categorized as very practical. In conclusion, the scientific literacy-based encyclopedia of Malay ethnic medicinal plants is valid and practical to be used as a learning resource in the Ethnobotany course. Keywords: ADDIE, encyclopedia, Malay ethnic group, medicinal plants, scientific literacy
Copyright (c) 2025 Rahmat Fajrin, Ashar Hasairin, Diky Setya Diningrat http://creativecommons.org/licenses/by-nc/4.0
Pengembangan Buku SMA Biologi Kelas XI Semester Ganjil Berbasis Kasus untuk Meningkatkan HOTs
This study aims to improve students' High Order Thinking Skills (HOTs) in high school biology by developing a case-based biology textbook. The research method used is the ADDIE development model, which includes Analysis, Design, Development, Implementation, and Evaluation. Data collection involved feasibility testing, practicality testing, and effectiveness testing. The results showed that the case-based biology textbook obtained a feasibility score of 95.8%, a practicality score of 95.5%, and an effectiveness score with an n-gain of 0.46 (moderate category). In conclusion, the developed case-based biology textbook is considered feasible, practical, and effective in enhancing high school students' HOTs. Keywords: ADDIE, Textbook, HOTs, Case, Senior High School
Copyright (c) 2025 Lasrini Lasrini, Martina Restuati, Hasruddin Hasruddin http://creativecommons.org/licenses/by-nc/4.0
Pengembangan Buku Keanekaragaman Jamur Makroskopis Berbasis Literasi Sains untuk Meningkatkan Berpikir Kritis pada Mahasiswa Pendidikan Biologi UNIMED
This study aims to develop a science-based learning resource on the diversity of macroscopic fungi that can enhance the critical thinking skills of students in the Biology Education Program at FMIPA UNIMED. The research method used is development research employing the ADDIE model, which consists of five phases: analysis, design, development, implementation, and evaluation. The validation results from subject matter experts, instructional design experts, and layout design experts indicate that the developed textbook is highly suitable for use, with an average rating of 94.2%. The trial in the experimental class shows a significant improvement in student learning outcomes, with the average post-test score rising from 70.50 to 92.10. Based on these results, it can be concluded that the developed textbook is effective in improving students' understanding and critical thinking skills. Keywords: Critical Thinking, Science-Based Textbook, Diversity of Fungi, Development Research, ADDIE Model
Copyright (c) 2025 Fathur Rahmi, Hasruddin Hasruddin, Ashar Hasairin http://creativecommons.org/licenses/by-nc/4.0