Penelusuran Senyawa Inhibitor Alpha-Glukosidase Potensial untuk Diabetes Melitus Tipe 2 melalui Pendekatan In Silico dengan Evaluasi Profil Adme Via SwissADME.

Authors

Nurfadilah Akademi Farmasi Persada

DOI:

Abstract

The aim of this study was to demonstrate data retrieval from online databases to find compounds with relevant properties such as alpha-glucosidase inhibitors, which have the potential to be used in the treatment of Type 2 Diabetes Mellitus. The methods used included compound search, physicochemical property analysis, and drug-likeness prediction using Lipinski's Rule of Five as well as ADME profile evaluation using the SwissADME platform. Preliminary results showed that Miglitol and Quercetin have promising drug-likeness profiles, comply with Lipinski's Rule of Five, and exhibit good ADME characteristics. Although Acarbose, as an effective drug, does not meet all Lipinski criteria due to its specific mechanism of action. The conclusion of this study confirms the efficiency of the in-silico approach in the initial screening of drug candidates but requires further experimental validation to confirm its activity and safety.

Keywords: ADME, Alpha-Glucosidase Inhibitor, Drug-Likeness, In Silico, SwissADME, Type 2 Diabetes Mellitus.

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