Interferon Nebulation in COVID-19 Patients
DOI:
https://doi.org/10.31539/jks.v8i2.14726Abstract
This study aims to see how effective interferon nebulization therapy is in COVID-19 patients. The method used is rapid review. The results of the study showed that rSIFN-co therapy has advantages, namely the duration of faster clinical improvement, the time for negative conversion of viral nucleic acid on mechanical ventilation is also shorter. While interferon-alpha therapy itself, because it still uses traditional principles, clinical improvement that occurs is a little slow. Conclusion, the use of interferon-alpha is less effective for the treatment of COVID-19 than the use of rSIFN-co therapy.
Keywords: COVID-19, Interferon, Nebulization
References
Beigel, J. H., Tomashek, K. M., Dodd, L. E., Mehta, A. K., Zingman, B. S., Kalil, A. C., Hohmann, E., Chu, H. Y., Luetkemeyer, A., Kline, S., Lopez de Castilla, D., Finberg, R. W., Dierberg, K., Tapson, V., Hsieh, L., Patterson, T. F., Paredes, R., Sweeney, D. A., Short, W. R., & Lane, H. C. (2020). Remdesivir for the Treatment of Covid-19 — Final Report. New England Journal of Medicine, 383(19), 1813–1826. https://doi.org/10.1056/nejmoa2007764
Cao, B., Wang, Y., Wen, D., Liu, W., Wang, J., Fan, G., Ruan, L., Song, B., Cai, Y., Wei, M., Li, X., Xia, J., Chen, N., Xiang, J., Yu, T., Bai, T., Xie, X., Zhang, L., Li, C., & Wang, C. (2020). A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19. New England Journal of Medicine, 382(19), 1787–1799. https://doi.org/10.1056/nejmoa2001282
Chen, W. C., Hsu, C. K., Chen, C. Y., Lai, C. C., Hung, S. H., & Lin, W. T. (2022). Clinical Efficacy and Safety of Interferon-Β–Containing Regimens In The Treatment Of Patients with COVID-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Expert Review of Anti-Infective Therapy, 20(5), 741–747. https://doi.org/10.1080/14787210.2022.2004118
Eisen, D. P., Leder, K., Woods, R. L., Lockery, J. E., McGuinness, S. L., Wolfe, R., Pilcher, D., Moore, E. M., Shastry, A., Nelson, M. R., Reid, C. M., McNeil, J. J., & McBryde, E. S. (2021). Effect of Aspirin on Deaths Associated with Sepsis In Healthy Older People (ANTISEPSIS): A Randomised, Double-Blind, Placebo-Controlled Primary Prevention Trial. The Lancet Respiratory Medicine, 9(2), 186–195. https://doi.org/10.1016/S2213-2600(20)30411-2
Hasselbalch, H. C., Skov, V., Kjær, L., Ellervik, C., Poulsen, A., Poulsen, T. D., & Nielsen, C. H. (2021). COVID-19 as a Mediator of Interferon Deficiency and Hyperinflammation: Rationale for the Use of JAK1/2 Inhibitors in Combination with Interferon. Cytokine & Growth Factor Reviews, 60, 28–45. https://doi.org/10.1016/j.cytogfr.2021.03.006
Jiang, Z., Liang, H., Peng, G., Wang, S., Zhang, B., Sun, Q., Xu, Y., Zeng, H., & Huang, J. (2022). Effect of IFN-α and Other Commonly Used Nebulization Drugs in Different Nebulization Methods on the Resistance of Breathing Circuit Filters Under Invasive Mechanical Ventilation. Annals of Translational Medicine, 10(4), 189–189. https://doi.org/10.21037/atm-22-84
Li, C., Luo, F., Liu, C., Xiong, N., Xu, Z., Zhang, W., Yang, M., Wang, Y., Liu, D., Yu, C., Zeng, J., Zhang, L., Li, D., Liu, Y., Feng, M., Liu, R., Mei, J., Deng, S., Zeng, Z., & Liu, L. (2021). Effect of a Genetically Engineered Interferon-Alpha Versus Traditional Interferon-Alpha In The Treatment of Moderate-To-Severe COVID-19: A Randomised Clinical Trial. Annals of Medicine, 53(1), 391–401. https://doi.org/10.1080/07853890.2021.1890329
Lim, Y. K., Kweon, O. J., Choi, Y., Kim, T. H., & Lee, M. K. (2023). Evaluation of ichromatm COVID-19 Interferon Gamma Release Assay for Detection of Vaccine-Induced Immunity in Healthcare Workers. Clinical Chemistry and Laboratory Medicine, 61(3), 503–509. https://doi.org/10.1515/cclm-2022-0914
Monk, P. D., Marsden, R. J., Tear, V. J., Brookes, J., Batten, T. N., Mankowski, M., Gabbay, F. J., Davies, D. E., Holgate, S. T., Ho, L. P., Clark, T., Djukanovic, R., Wilkinson, T. M. A., Crooks, M. G., Dosanjh, D. P., Siddiqui, S., Rahman, N. M., Smith, J. A., Horsley, A., & Rodrigues, P. M. (2021). Safety and Efficacy of Inhaled Nebulised Interferon Beta-1a (SNG001) for Treatment of SARS-CoV-2 Infection: A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Trial. The Lancet Respiratory Medicine, 9(2), 196–206. https://doi.org/10.1016/S2213-2600(20)30511-7
Nugraha, B., Wahyuni, L. K., Laswati, H., Kusumastuti, P., Tulaar, A. B. M., & Gutenbrunner, C. (2020). COVID-19 Pandemic in Indonesia: Situation and Challenges of Rehabilitation Medicine in Indonesia. Acta Medica Indonesiana, 52(3), 299–305.
Ochani, R. K., Asad, A., Yasmin, F., Shaikh, S., Khalid, H., Batra, S., Sohail, M. R., Mahmood, S. F., Ochani, R., Arshad, M. H., Kumar, A., & Surani, S. (2021). Covid-19 Pandemic: From Origins to Outcomes. A Comprehensive Review of Viral Pathogenesis, Clinical Manifestations, Diagnostic Evaluation, and Management. Infezioni in Medicina, 29(1), 20–36. https://pubmed.ncbi.nlm.nih.gov/33664170/
Pan, Y. Y., Wang, L. C., Yang, F., & Yu, M. (2023). Interferon-Lambda: New Role in Intestinal Symptoms of COVID-19. World Journal of Gastroenterology, 29(13), 1942–1954. https://doi.org/10.3748/WJG.V29.I13.1942
Primorac, D., Vrdoljak, K., Brlek, P., Pavelić, E., Molnar, V., Matišić, V., Erceg Ivkošić, I., & Parčina, M. (2022). Adaptive Immune Responses and Immunity to SARS-CoV-2. Frontiers in Immunology, 13(May), 1–13. https://doi.org/10.3389/fimmu.2022.848582
Samuel, C. E. (2023). Interferon at the Crossroads of SARS-CoV-2 Infection and COVID-19 Disease. Journal of Biological Chemistry, 299(8), 104960. https://doi.org/10.1016/j.jbc.2023.104960
Sharma, A., Farouk, I. A., & Lal, S. K. (2021). Covid-19: A Review on the Novel Coronavirus Disease Evolution, Transmission, Detection, Control and Prevention. Viruses, 13(2), 1–25. https://doi.org/10.3390/v13020202
Sosa, J. P., Caceres, M. M. F., Comptis, J. R., Quiros, J., Príncipe-Meneses, F. S., Riva-Moscoso, A., Belizaire, M. P., Malanyaon, F. Q., Agadi, K., Jaffery, S. S., Sahajwani, J., Arshia, A., Senatus, A., Verdecia, G., Akano, L., Razzack, A. A., Salam, S., Gadamidi, V. K., & Marian, S. (2021). Effects of Interferon Beta in COVID-19 Adult Patients: Systematic Review. Infection and Chemotherapy, 53(2), 247–260. https://doi.org/10.3947/IC.2021.0028
Susilo, A., Rumende, C. M., Pitoyo, C. W., & Santoso, W. D. (2020). Coronavirus Disease 2019 : Tinjauan Literatur Terkini Coronavirus Disease 2019 : Review of Current Literatures. Jurnal Penyakit Dalam Indonesia, 2020. Jurnal Penyakit Dalam Indonesia, 7(1), 45-67. http://dx.doi.org/10.7454/jpdi.v7i1.415
Tali, S. H. S., LeBlanc, J. J., Sadiq, Z., Oyewunmi, O. D., Camargo, C., Nikpour, B., Armanfard, N., Sagan, S. M., & Jahanshahi-Anbuhi, S. (2021). Tools and Techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 Detection. Clinical Microbiology Reviews, 34(3), 1–63. https://doi.org/10.1128/CMR.00228-20
Wang, N., Zhan, Y., Zhu, L., Hou, Z., Liu, F., Song, P., Qiu, F., Wang, X., Zou, X., Wan, D., Qian, X., Wang, S., Guo, Y., Yu, H., Cui, M., Tong, G., Xu, Y., Zheng, Z., Lu, Y., & Hong, P. (2020). Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients. Cell Host and Microbe, 28(3), 455-464.e2. https://doi.org/10.1016/j.chom.2020.07.005
Zhou, Q., Chen, V., Shannon, C. P., Wei, X. S., Xiang, X., Wang, X., Wang, Z. H., Tebbutt, S. J., Kollmann, T. R., & Fish, E. N. (2020). Interferon-α2b Treatment for COVID-19. Frontiers in Immunology, 11(May), 1–6. https://doi.org/10.3389/fimmu.2020.01061
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