Penggunaan Madu Topikal Efektif terhadap Penyembuhan Luka Kronis

  • Etty Etty Rumah Sakit Umum Daerah H. Andi Sulthan Daeng Radja Bulukumba
  • Yuliana Syam Universitas Hasanuddin Makassar
  • Saldy Yusuf Universitas Hasanuddin Makassar


The aim of this study was to determine the effectiveness of topical honey in chronic wound healing. This research method uses a literature review method using five databases in search of articles, namely Pubmed, ProQuest, Science Direct, Wiley Online Library, and Google Scholar. The results of the literature review are from six research articles analyzed, five research articles showed that honey was effective against chronic wound healing compared to normal saline, povidone iodine and other therapies (p value <0.05), but one article was not statistically significant. In conclusion, the use of honey as a topical therapy which is effective in treating chronic wounds is due to the nutritional content or properties of honey.


Keywords: Chronic Wounds, Honey, Wound Healing, Ulcers


Bokaiean, R., Momeni, M., Sabrjoo, P., Dahmardehei, M., Roham, M., & Rahber, H. (2018). Comparing Active Leptospermum Honey Dressing with Conventional Dressing in Skin graft donor sites. Iranian Journal of Dermatology, 21(1), 1–6

Cohen-Mansfield, Maha Dakheel-Ali, MDb, Marcia S. Marx, PhDb, Khin Thein, MDb, and Natalie G. Regier, P. (2017). Biology and Biomarkers for Wound Healing. Physiology & Behavior, 176(1), 139–148.

Dzugan, M., Tomczyk, M., Sowa, P., & Grabek-Lejko, D. (2018). Antioxidant Activity as Biomarker of Honey Variety. Molecules, 23(8), 1–14.

Ghazali, W. S. W., Romli, A. C., & Mohamed, M. (2017). Effects of Honey Supplementation on Inflammatory Markers among Chronic Smokers: A Randomized Controlled Trial. BMC Complementary and Alternative Medicine, 17(1), 4–9.

Han, G., & Ceilley, R. (2017). Chronic Wound Healing: A Review of Current Management and Treatments. Advances in Therapy, 34(3), 599–610.

Henatsch, D., den Hartog, G. J. M., Duijvestijn, A. M., Wolffs, P. F., Phielix, E., Stokroos, R. J., & Briedé, J. J. (2018). The Contribution of α-Dicarbonyl Compound Dependent Radical Formation to the Antiseptic Effect of Honey. Journal of Functional Foods, 45(April), 239–246.

Joret, M. O., Osman, K., Dean, A., Cao, C., van der Werf, B., & Bhamidipaty, V. (2019). Multidisciplinary Clinics Reduce Treatment Costs and Improve Patient Outcomes in Diabetic Foot Disease. Journal of Vascular Surgery, 70(3), 806–814.

Joshi, H., Tirthkumar, R., & Aakash, A. (2019). Effect of Honey Impregnated Dressing v/s Silver Sulfadiazine in Healing of Chronic Ulcer and Burns. International Journal of Surgery Science, 3(4), 209–216.

Koujalagi, R. S., Uppin, V. M., Shah, S., & Sharma, D. (2020). One Year Randomized Controlled Trial to Compare the Effectiveness of Honey Dressing Versus Povidone Iodine Dressing for Diabetic Foot Ulcer at Dr. Prabhakar Kore Hospital and MRC, Belagavi. International Surgery Journal, 7(2), 506.

Martinotti, S., & Ranzato, E. (2018). Honey, Wound Repair and Regenerative Medicine. Journal of Functional Biomaterials, 9(2).

Meka, M. (2017). Comparison of Conventional Normal Saline Dressing and Honey Dressing In the Management of Chronic Non-Healing Ulcers. Journal of Medical Science And Clinical Research, 05(03), 19214–19217.

Meo, S. A., Al-Asiri, S. A., Mahesar, A. L., & Ansari, M. J. (2017). Role of Honey in Modern Medicine. Saudi Journal of Biological Sciences, 24(5), 975–978.

Minden, B., & Bowlin, G. (2018). Honey-Based Templates in Wound Healing and Tissue Engineering. Bioengineering, 5(2).

Nweze, A. J., Olovo, V. C., Innocent, N. E., Okechukwu, J. O., & Paul, C. (2020). Therapeutic Properties of Honey. Honey Analysis - New Advances and Challenges, 1–21.

Ose, M., Utami, P., & Damayanti, A. (2018). Efektivitas Perawatan Luka Teknik Balutan Wet-Dry dan Moist Wound Healing pada Penyembuhan Ulkus Diabetik. Journal of Borneo Holistic Health, 1(1), 101–112

Pasupuleti, V. R., Sammugam, L., Ramesh, N., & Gan, S. H. (2017). Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxidative Medicine and Cellular Longevity, 2017.

Samarghandian, S., Farkhondeh, T., & Samini, F. (2017). Honey and Health: A Review of Recent Clinical Research. Pharmacognosy Research, 9(2), 121–127.

Serena, T. E., Yaakov, R. A., DeLegge, M., Mayhugh, T. A., & Moore, S. (2018). Nutrition in Patients with Chronic Non-Healing Ulcers: A Paradigm Shift in Wound Care. Chronic Wound Care Management and Research, Volume 5, 5–9.

Snyder, R. J., Fife, C., & Moore, Z. (2016). Components and Quality Measures of DIME (Devitalized Tissue, Infection/Inflammation, Moisture Balance, and Edge Preparation) in Wound Care. Advances in Skin and Wound Care, 29(5), 205–215.

Syam, Y., Natsir, R., Rahardjo, S. P., Usman, A. N., Dwiyanti, R., & Hatta, M. (2016). Effect of Trigona Honey to mRNA Expression of Interleukin-6 on Salmonella Typhi Induced of BALB/c Mice. American Journal of Microbiological Research, 4(3), 77–80.

Tapiwa, C. E. (2018). Clinical Management of Non-Healing Wounds. Nursing Standard, 32(29), 48–63.

Tsang, K. K., Kwong, E. W. Y., To, T. S. S., Chung, J. W. Y., & Wong, T. K. S. (2017). A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer. Evidence-Based Complementary and Alternative Medicine, 2017.

Wang, H., Horng, H., Ching, C., & Chen, Y. J. (2017). Wound Healing. Journal of the Chinese Medical Association, 81(2), 94–101.
Weller, C., Weller, C., & Team, V. (2019). Interactive Dressings and Their Role in Moist Wound Management. In Advanced Textiles for Wound Care (Second Edi). Elsevier Ltd.

Zeleníková, R., & Vyhlídalová, D. (2019). Applying Honey Dressings to Non-Healing Wounds in Elderly Persons Receiving Home Care. Journal of Tissue Viability, 28(3), 139–143.

Zhang, X., Shu, W., Yu, Q., Qu, W., Wang, Y., & Li, R. (2020). Functional Biomaterials for Treatment of Chronic Wound. Frontiers in Bioengineering and Biotechnology, 8(June), 1–15.
How to Cite
Etty, E., Syam, Y., & Yusuf, S. (2021). Penggunaan Madu Topikal Efektif terhadap Penyembuhan Luka Kronis. Jurnal Keperawatan Silampari, 4(2), 415-424.
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