Uji Efektivitas Ekstrak Umbi Bawang Putih (Allium Sativum l) terhadap Kadar Glukosa Darah Mencit (Mus Musculus) yang Diinduksi Aloksan
Abstract
This study aims to test the effectiveness of garlic bulbs on alloxan-induced blood glucose levels in mice. The method used is an actual experimental pretest-posttest control group design. The study revealed that garlic extract could reduce blood glucose levels in mice (p 0.05). The most doses of garlic extract that reduced blood glucose levels in diabetic mice were 6 mg/200 g BW and 12 mg/200 g BW. In conclusion, garlic extract significantly reduced blood glucose levels in diabetic mice when administered at 6 mg/200 g BW and 12 mg/200 g BW.
Keywords: Allin, Allisin, Anti Diabetes, Garlic
References
Amalia, A., Elfiyani, R., & Chenia, A. (2021). Peningkatan Laju Difusi Allisin dalam Sistem Fitosom Ekstrak Bawang Putih. Jurnal Ilmu Kefarmasian Indonesia, 19(1), 1. https://doi.org/10.35814/jifi.v19i1.842
Dewi, I. P., Orde, I. M., & Verawaty, V. (2020). Efektivitas Gel Ekstrak Etanol Bawang Putih (Allium Sativum l.) terhadap Bakteri Staphylococcus Aureus. Jurnal Riset Kefarmasian Indonesia, 2(2), 105–112. https://doi.org/10.33759/jrki.v2i2.84
Fadly, A. A. (2022). Pengaruh Ekstrak Bawang Putih (Allium sativum) terhadap Kadar Glukosa Darah pada Tikus Putih (Rattus norvegicus) yang Diinduksi Streptozotocin. Jurnal Medika Utama, 3(2), 1739–1744. http://jurnalmedikahutama.com/index.php/JMH/article/view/363
Fitria, L., Handayani, L., & Na’ilah, L. N. (2022). Reproductive Toxicity Study of Hairy Fig (Ficus Hispida L.f.) Fruits on Male Wistar Rats (Rattus norvegicus Berkenhout, 1769). Berkala Ilmiah Biologi, 13(1), 1–14. https://doi.org/10.22146/bib.v1i1.4270
Iftikhar, A., Aslam, B., Iftikhar, M., Majeed, W., Batool, M., Zahoor, B., Amna, N., Gohar, H., & Latif, I. (2020). Effect of Caesalpinia Bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway. Oxidative Medicine and Cellular Longevity, 2020. https://doi.org/10.1155/2020/9020219
Kementerian Kesehatan Republik Indonesia. (2022). Tahun 2030 Prevalensi Diabetes Melitus di Indonesia Mencapai 21,3 Juta Orang. Kementerian Kesehatan Republik Indonesia. https://www.kemkes.go.id/article/view/414/tahun-2030-prevalensi-diabetes-melitus-di-indonesia-mencapai-213-juta-orang.html
Krisnawan, A. H., Dharmawati, A. G., & Mallaleng, H. R. (2022). Formulasi Serbuk Instan Kombinasi Bawang Lanang Hitam (Allium sativum L .) dan Bunga Rosella (Hibiscus sabdariffa L) dengan Metode Foam Mat Drying Journal of Pharmacy & Science, 7(1), 15-20. https://doi.org/10.53342/pharmasci.v7i1.273
Liu, Y. J., McIntyre, R. L., Janssens, G. E., & Houtkooper, R. H. (2020). Mitochondrial Fission and Fusion: A Dynamic Role in Aging and Potential Target for Age-Related Disease. Mechanisms of Ageing and Development, 186(October 2019), 111212. https://doi.org/10.1016/j.mad.2020.111212
Maykish, A., & Sikalidis, A. K. (2020). Utilization of Hydroxyl-Methyl Butyrate, Leucine, Glutamine and Arginine Supplementation in Nutritional Management of Sarcopenia—Implications and Clinical Considerations for Type 2 Diabetes Mellitus Risk Modulation. Journal of Personalized Medicine, 10(1), 1-17. https://doi.org/10.3390/jpm10010019
Muntu, C. M., & Tenderan, I. P. (2022). Pengaruh Laju Alir pada Proses Spray Drying terhadap Karakteristik Fisiko Kimia Mikrosfer Glibenklamid menggunakan Polimer Kitosan dan Penyambung Silang Natrium Tripolifosfat. MPI (Media Pharmaceutica Indonesiana), 4(1), 13–22. https://doi.org/10.24123/mpi.v4i1.5045
Natasya, C., Miftahullaila, M., Sinamo, S., Nurul, N., & Griselda, J. (2020). Pengaruh Waktu Perendaman Plat Resin Akrilik dalam Perasan Murni Bawang Putih terhadap Jumlah Koloni Candida Albicans. Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 7(3), 25–30. https://doi.org/10.32539/jkk.v7i3.11483
Poernomo, H., & Ma’ruf, M. T. (2020). Pengaruh Gel Ekstrak Bawang Putih (Allium Sativum L.) terhadap Jumlah Sel Makrofag pada Penyembuhan Luka Insisi Gingiva Marmut (Cavia Porcellus). Interdental Jurnal Kedokteran Gigi (IJKG), 16(2), 34–39. https://doi.org/10.46862/interdental.v16i2.1065
Rajab, M. N., Edy, H. J., & Siampa, J. P. (2021). Formulasi Sediaan Salep Ekstrak Etanol Bawang Putih (Allium sativum L.) sebagai Antibakteri. Pharmacon, 10(3), 1–8. https://doi.org/10.35799/pha.10.2021.35604
Rijal, M. A., Purbomartono, C., & Jannah, I. F. (2022). Respon Pertumbuhan Ikan Nila (Oreochromis niloticus) yang Diberi Pakan Supplementasi Bawang Putih (Allium sativum) pada Sistem Bioflok. Sainteks, 18(2), 117. https://doi.org/10.30595/sainteks.v18i2.12773
Suryati, I., Primal, D., & Pordiati, D. (2019). Hubungan Tingkat Pengetahuan dan Lama Menderita Diabetes Mellitus (DM) dengan Kejadian Ulkus Diabetikum pada Pasien Dm Tipe 2. Jurnal Kesehatan Perintis (Perintis’s Health Journal), 6(1), 1–8. https://doi.org/10.33653/jkp.v6i1.214
Ueno, H., Haraguchi, N., Azuma, M., Shiiya, T., Noda, T., Ebihara, E., Uehira, Y., Uchida, T., Sasaba, K., Nakamura, M., Uchimura, N., Kita, E., Umemura, A., Nobe, T., Sumoto, E., Yano, Y., & Nakazato, M. (2021). Active Consumption of Konjac and Konjac Products Improves Blood Glucose Control in Patients with Type 2 Diabetes Mellitus. Journal of the American College of Nutrition, 0(0), 1–7. https://doi.org/10.1080/07315724.2021.2002739
Wakhidah, L., & Anggarani, M. A. (2021). Analisis Senyawa Bioaktif dan Aktivitas Antioksidan Ekstrak Bawang Putih (Allium Sativum L.) PROBOLINGGO. Unesa Journal of Chemistry, 10(3), 356–366. https://doi.org/10.26740/ujc.v10n3.p356-366
Widiastuti, L. (2020). Acupressure dan Senam Kaki terhadap Tingkat Peripheral Arterial Disease pada Klien DM Tipe 2. Jurnal Keperawatan Silampari, 3(2), 694–706. https://doi.org/10.31539/jks.v3i2.1200
World Health Organization. (2022). Diabetes. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/diabetes
Dewi, I. P., Orde, I. M., & Verawaty, V. (2020). Efektivitas Gel Ekstrak Etanol Bawang Putih (Allium Sativum l.) terhadap Bakteri Staphylococcus Aureus. Jurnal Riset Kefarmasian Indonesia, 2(2), 105–112. https://doi.org/10.33759/jrki.v2i2.84
Fadly, A. A. (2022). Pengaruh Ekstrak Bawang Putih (Allium sativum) terhadap Kadar Glukosa Darah pada Tikus Putih (Rattus norvegicus) yang Diinduksi Streptozotocin. Jurnal Medika Utama, 3(2), 1739–1744. http://jurnalmedikahutama.com/index.php/JMH/article/view/363
Fitria, L., Handayani, L., & Na’ilah, L. N. (2022). Reproductive Toxicity Study of Hairy Fig (Ficus Hispida L.f.) Fruits on Male Wistar Rats (Rattus norvegicus Berkenhout, 1769). Berkala Ilmiah Biologi, 13(1), 1–14. https://doi.org/10.22146/bib.v1i1.4270
Iftikhar, A., Aslam, B., Iftikhar, M., Majeed, W., Batool, M., Zahoor, B., Amna, N., Gohar, H., & Latif, I. (2020). Effect of Caesalpinia Bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway. Oxidative Medicine and Cellular Longevity, 2020. https://doi.org/10.1155/2020/9020219
Kementerian Kesehatan Republik Indonesia. (2022). Tahun 2030 Prevalensi Diabetes Melitus di Indonesia Mencapai 21,3 Juta Orang. Kementerian Kesehatan Republik Indonesia. https://www.kemkes.go.id/article/view/414/tahun-2030-prevalensi-diabetes-melitus-di-indonesia-mencapai-213-juta-orang.html
Krisnawan, A. H., Dharmawati, A. G., & Mallaleng, H. R. (2022). Formulasi Serbuk Instan Kombinasi Bawang Lanang Hitam (Allium sativum L .) dan Bunga Rosella (Hibiscus sabdariffa L) dengan Metode Foam Mat Drying Journal of Pharmacy & Science, 7(1), 15-20. https://doi.org/10.53342/pharmasci.v7i1.273
Liu, Y. J., McIntyre, R. L., Janssens, G. E., & Houtkooper, R. H. (2020). Mitochondrial Fission and Fusion: A Dynamic Role in Aging and Potential Target for Age-Related Disease. Mechanisms of Ageing and Development, 186(October 2019), 111212. https://doi.org/10.1016/j.mad.2020.111212
Maykish, A., & Sikalidis, A. K. (2020). Utilization of Hydroxyl-Methyl Butyrate, Leucine, Glutamine and Arginine Supplementation in Nutritional Management of Sarcopenia—Implications and Clinical Considerations for Type 2 Diabetes Mellitus Risk Modulation. Journal of Personalized Medicine, 10(1), 1-17. https://doi.org/10.3390/jpm10010019
Muntu, C. M., & Tenderan, I. P. (2022). Pengaruh Laju Alir pada Proses Spray Drying terhadap Karakteristik Fisiko Kimia Mikrosfer Glibenklamid menggunakan Polimer Kitosan dan Penyambung Silang Natrium Tripolifosfat. MPI (Media Pharmaceutica Indonesiana), 4(1), 13–22. https://doi.org/10.24123/mpi.v4i1.5045
Natasya, C., Miftahullaila, M., Sinamo, S., Nurul, N., & Griselda, J. (2020). Pengaruh Waktu Perendaman Plat Resin Akrilik dalam Perasan Murni Bawang Putih terhadap Jumlah Koloni Candida Albicans. Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 7(3), 25–30. https://doi.org/10.32539/jkk.v7i3.11483
Poernomo, H., & Ma’ruf, M. T. (2020). Pengaruh Gel Ekstrak Bawang Putih (Allium Sativum L.) terhadap Jumlah Sel Makrofag pada Penyembuhan Luka Insisi Gingiva Marmut (Cavia Porcellus). Interdental Jurnal Kedokteran Gigi (IJKG), 16(2), 34–39. https://doi.org/10.46862/interdental.v16i2.1065
Rajab, M. N., Edy, H. J., & Siampa, J. P. (2021). Formulasi Sediaan Salep Ekstrak Etanol Bawang Putih (Allium sativum L.) sebagai Antibakteri. Pharmacon, 10(3), 1–8. https://doi.org/10.35799/pha.10.2021.35604
Rijal, M. A., Purbomartono, C., & Jannah, I. F. (2022). Respon Pertumbuhan Ikan Nila (Oreochromis niloticus) yang Diberi Pakan Supplementasi Bawang Putih (Allium sativum) pada Sistem Bioflok. Sainteks, 18(2), 117. https://doi.org/10.30595/sainteks.v18i2.12773
Suryati, I., Primal, D., & Pordiati, D. (2019). Hubungan Tingkat Pengetahuan dan Lama Menderita Diabetes Mellitus (DM) dengan Kejadian Ulkus Diabetikum pada Pasien Dm Tipe 2. Jurnal Kesehatan Perintis (Perintis’s Health Journal), 6(1), 1–8. https://doi.org/10.33653/jkp.v6i1.214
Ueno, H., Haraguchi, N., Azuma, M., Shiiya, T., Noda, T., Ebihara, E., Uehira, Y., Uchida, T., Sasaba, K., Nakamura, M., Uchimura, N., Kita, E., Umemura, A., Nobe, T., Sumoto, E., Yano, Y., & Nakazato, M. (2021). Active Consumption of Konjac and Konjac Products Improves Blood Glucose Control in Patients with Type 2 Diabetes Mellitus. Journal of the American College of Nutrition, 0(0), 1–7. https://doi.org/10.1080/07315724.2021.2002739
Wakhidah, L., & Anggarani, M. A. (2021). Analisis Senyawa Bioaktif dan Aktivitas Antioksidan Ekstrak Bawang Putih (Allium Sativum L.) PROBOLINGGO. Unesa Journal of Chemistry, 10(3), 356–366. https://doi.org/10.26740/ujc.v10n3.p356-366
Widiastuti, L. (2020). Acupressure dan Senam Kaki terhadap Tingkat Peripheral Arterial Disease pada Klien DM Tipe 2. Jurnal Keperawatan Silampari, 3(2), 694–706. https://doi.org/10.31539/jks.v3i2.1200
World Health Organization. (2022). Diabetes. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/diabetes
Published
2022-12-31
Section
Articles
Copyright (c) 2022 Sri Lestari Ramadhani Nasution, Yeni Puspawani, Sintiya Hamdi, Kezia Debora
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
