Chemotherapy for Leukemia Children on Elevated Creatinine Ureum Levels
Abstract
This study aims to determine urea and creatine levels before and after chemotherapy in childhood leukemia. The research method used in this research is Quasi Experiment Pretest-posttest research. The results of the study show that based on the univariate analysis that has been carried out, it is known that the highest age of children with leukemia is school age (6-12 years). The most common gender of childhood leukemia is male, and the most common type of childhood leukemia is Acute Lymphoblastic Leukemia (ALL). Meanwhile, in the bivariate analysis after the Wilcoxon test, the p-value of urea levels before and after chemotherapy was 0.808 > 0.05, and the p-value of creatinine levels before and after chemotherapy was 0.1000 > 0.05. In conclusion, there is no difference in urea and creatinine levels before and after chemotherapy in children with leukemia.
Keywords: Chemotherapy, Ureum Creatinine, Childhood Leukemia
References
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Ford, M., Mauro, M., Aftandilian, C., Sakamoto, K. M., & Hijiya, N. (2022). Management of Chronic Myeloid Leukemia in Children and Young Adults. Current Hematologic Malignancy Reports, 17(5), 121–126. https://doi.org/https://doi.org/10.1007/s11899-022-00673-5
Hamed, K. M., Dighriri, I. M., Baomar, A. F., Alharthy, B. T., Alenazi, F. E., Alali, G. H., Alenazy, R. H., Alhumaidi, N. T., Alhulayfi, D. H., Alotaibi, Y. B., Alhumaidan, S. S., Alhaddad, Z. A., Humadi, A. A., Alzahrani, S. A., & Alobaid, R. H. (2022). Overview of Methotrexate Toxicity: A Comprehensive Literature Review. Cureus. https://doi.org/https://doi.org/10.7759/cureus.29518
Hermanto, H. D., Mayangsari, E., & Fadriyana, P. A. (2021). Side Effects of Carboplatin-Based Chemotherapy on Kidney Function in Gynaecological Cancer Patients. Majalah Kesehatan, 8(3), 137-148. https://majalahfk.ub.ac.id/index.php/mkfkub/article/view/484/268
Hoeben, B. A. W., Pazos, M., Seravalli, E., Bosman, M. E., Losert, C., Albert, M. H., Boterberg, T., Ospovat, I., Mico Milla, S., Demiroz Abakay, C., Engellau, J., Jóhannesson, V., Kos, G., Supiot, S., Llagostera, C., Bierings, M., Scarzello, G., Seiersen, G. O. (2022). ESTRO ACROP and SIOPE recommendations for myeloablative Total Body Irradiation in children. Radiotherapy and Oncology, 173, 119–133. https://doi.org/https://doi.org/10.1016/j.radonc.2022.05.027
Karol, S. E., Alexander, T. B., Budhraja, A., Pounds, S. B., Canavera, K., Wang, L., Wolf, J., Klco, J. M., Mead, P. E., Das Gupta, S., Kim, S. Y., Salem, A. H., Palenski, T., Lacayo, N. J., Pui, C. H., Opferman, J. T., & Rubnitz, J. E. (2020). Venetoclax in Combination with Cytarabine with or Without Idarubicin in Children with Relapsed or Refractory Acute Myeloid Leukaemia: A Phase 1, Dose-Escalation Study. The Lancet Oncology2, 21(4), 551–560. https://doi.org/https://doi.org/10.1016/S1470-2045(20)30060-7
Lam, S. Y., Chan, E. Y., Cheng, F. W. T., Ma, A. L. T., & Ha, S. Y. (2023). Acute Kidney Injury in Children with Haematological Malignancy: A Territory-Wide Study. Pediatric Nephrology, 38, 3823–3833. https://doi.org/https://doi.org/10.1007/s00467-023-06010-z
Li, H., Xu, Q., Wang, Y., Chen, K., & Li, J. (2020). Serum Neutrophil Gelatinase-Associated Lipocalin (Ngal) As A Biomarker for Predicting High Dose Methotrexate Associated Acute Kidney Injury in Children with Acute Lymphoblastic Leukemia. Cancer Chemotherapy and Pharmacology, 85(1), 95–103. https://doi.org/https://doi.org/10.1007/s00280-019-03980-6
Limratchapong, C., Sophark, P., Vachvanichsanong, P., McNeil, E. B., & Chotsampancharoen, T. (2022). Acute Kidney Injury and Childhood Acute Myeloid Leukemia. Pediatric Nephrology, 37(11), 2765–2770. https://doi.org/https://doi.org/10.1007/s00467-022-05506-4
M’harzi, S., Elouali, A., Lahrache, K., Ghanam, A., Babakhouya, A., Rkain, M., & Benajiba, N. (2022). Acute Pancreatitis Following L-Asparaginase in Acute Lymphoblastic Leukemia. Leukemia Research Reports, 18. https://doi.org/https://doi.org/10.1016/j.lrr.2022.100357
Nuraini, D., & Mariyam, M. (2020). Physiological Impact of Post Chemotherapy in Children with Acute Lymphocytic Leukaemia (LLA). Ners Muda, 1(2), 120. https://doi.org/https://doi.org/10.26714/nm.v1i2.5795
Pojoh, V. S., Mantik, M. F. J., & Manoppo, J. I. C. (2019). Relationship between Body Mass Index and the Achievement of Remission in Children with Acute Lymphoblastic Leukaemia. E-CliniC, 8(1). https://doi.org/https://doi.org/10.35790/ecl.8.1.2020.27186
Queudeville, M., & Ebinger, M. (2021). Blinatumomab in pediatric acute Lymphoblastic Leukemia-from Salvage to First Line Therapy (A Systematic Review). Journal of Clinical Medicine, 10(12). https://doi.org/https://doi.org/10.3390/jcm10122544
Rubnitz, J. E., & Kaspers, G. J. L. (2021). How I Treat Pediatric Acute Myeloid Leukemia. Blood, 138(12), 1009–1018. https://doi.org/10.1182/blood.2021011694
Shields, L. B. E., Peppas, D. S., & Rosenberg, E. (2019). Pelvic Neuroblastoma Presenting with Acute Urinary Retention and Acute Kidney Injury. Urology Case Reports, 23, 82–84. https://doi.org/https://doi.org/10.1016/j.eucr.2019.01.003
Thastrup, M., Duguid, A., Mirian, C., Schmiegelow, K., & Halsey, C. (2022). Central Nervous System Involvement in Childhood Acute Lymphoblastic Leukemia: Challenges and Solutions. Leukemia, 36(12), 2751–2768. https://doi.org/https://doi.org/10.1038/s41375-022-01714-x
Vijayasekharan, K., Bhat K, V., Venkatagiri, A. M., Godkhindi, V. M., Laxminarayana, S. L. K., & Belurkar, S. (2021). Bilateral Massive Nephromegaly–A Rare Presentation of T-Cell Acute Lymphoblastic Leukemia. Leukemia Research Reports, 15. https://doi.org/https://doi.org/10.1016/j.lrr.2021.100246
Yang, W., Cai, J., Shen, S., Gao, J., Yu, J., Hu, S., Jiang, H., Fang, Y., Liang, C., Ju, X., Wu, X., Zhai, X., Tian, X., Wang, N., Liu, A., Jiang, H., Jin, R., Sun, L., Yang, M., & Pui, C. H. (2021). Pulse Therapy with Vincristine and Dexamethasone for Childhood Acute Lymphoblastic Leukaemia (CCCG-ALL-2015): An Open-Label, Multicentre, Randomised, Phase 3, Non-Inferiority Trial. The Lancet Oncology, 22(9), 1322–1332. https://doi.org/https://doi.org/10.1016/S1470-2045(21)00328-4
Published
2023-11-15
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Copyright (c) 2023 Aslinda Aslinda, Ratna Mahmud, Harmawati Harmawati, Rahdiastuti Andi Patangai, Ayuni Maulidiya
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