Perbandingan Kadar Fe dan Zn pada Penderita TB dengan Riwayat DM dan Non DM
Abstract
This study aims to determine the levels of Fe and Zn serum in patients with pulmonary TB with DM and without DM. The research method used is descriptive-analytical with a cross-sectional approach. The results showed that the average level of iron (Fe) serum in patients with pulmonary TB was 111.67 μg / dL, and the average level of iron (Fe) serum in patients with pulmonary TB with DM was 61.23, μg / dL. For serum zinc levels, the average level of zinc (Zn) serum in patients with pulmonary TB was 101.29 μg / dL, and the average level of zinc serum in patients with pulmonary TB with DM was 76.38 μg / dL. The study concludes that there is a difference in the average levels of Fe and Zn in patients with pulmonary TB and patients with pulmonary TB with DM.
Keywords: Fe, TB, TB-DM, Zinc
References
Achmad, M., Djasang, S., Nuradi, N., & Hadijah, S. (2022). Kadar Hemoglobin pada Penderita Tuberkulosis Paru yang Mengkonsumsi Obat Anti Tuberkulosis. Jurnal Media Analis Kesehatan. 12(1), 64-70. https://doi.org/10.32382/mak.v13i1.2765
Ahmad, R., Shaju, R., Atfi, A., & Razzaque, M. S. (2024). Zinc and Diabetes: A Connection between Micronutrient and Metabolism. Cells, 13(16), 1359. https://doi.org/10.3390/cells13161359
Amelia, S., & Kaswandani, N. (2024). Correlation between Tuberculosis Type and Comorbidities with Nutritional Recovery Rates Post-Tuberculosis Treatment in Pediatric Patients. Archives of Pediatric Gastroenterology, Hepatology, and Nutrition,3(3), 1-11. https://doi.org/10.58427/apghn.3.3.2024.1-11
Barman, N., Khan, M. M. H., Ghosh, D., Towhid, M. I. I., Uddin, M. N., Paul, D., Haque, M. A. (2021). Serum Zinc Level and its Association with Multidrug-Resistant Tuberculosis. International Journal of Mycobacteriology, 10(2), 177-181. https://doi.org/10.4103/ijmy.ijmy_67_21
Bisht, M. K., & Dahiya, P. (2023). The Cause-Effect Relation of Tuberculosis on Incidence of Diabetes Mellitus. Front Cell Infect Microbiol.13, 1134036. https://doi.org/10.3389/fcimb.2023.1134036
Carin, V., Anwar, K., Irawati, S., & Maharani, Y. (2024). Asuhan Gizi pada Pasien Tuberkulosis Paru, Acute Lymphadenitis, dan Sindrom Nefrotik. Binawan Student Journal, 6(2), 144-152. https://doi.org/10.54771/57xj1a78
Caturano, A., D'Angelo, M., Mormone, A., Russo, V., Mollica, M. P., Salvatore, T., Galiero, R., Rinaldi, L., Vetrano, E., Marfella, R., Monda, M., Giordano, A., & Sasso, F. C. (2023). Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications. Current issues in molecular biology, 45(8), 6651–6666. https://doi.org/10.3390/cimb45080420
Fiorino, G., Colombel, J-F., Katsanos, K., Mearin, F., Stein, J., Andretta, M., Antonacci, S., Arenare, L., Citraro, R., Dell'Orco, S., Esposti, L. D., Serna, A. R. de A., Morin, N., & Koutroubakis, I. E. (2023). Iron Deficiency Anemia Impacts Disease Progression and Healthcare Resource Consumption in Patients with Inflammatory Bowel Disease: A Real-World Evidence Study. Therapeutic advances in gastroenterology, 16. https://doi.org/10.1177/17562848231177153
Hamed, A. M., Hadidy, K. E. S. E., & Salem, M. N. ( 2022). Ferritin as a Marker of Insulin Resistance in Diabetic Patients. Egyptian Journal of Medical Research. 3(2), 110-120. https://doi.org/10.21608/ejmr.2022.237765
Hasan, F. E., & Yunus, R. (2023). Antioxidant Function in Inhibiting Lipid Peroxidation and Increasing Erythrocyte Membrane Resistance in Diabetes Mellitus Patients. Health Information: Jurnal Penelitian, 15(2). https://doi.org/10.36990/hijp.v15i2.901
IDF. (2021). IDF Diabetes Atlas. https://www.diabetesatlas.org/data/en/country/94/id.html
Kemkes RI. (2020). Pedoman Nasional Pengendalian Tuberkulosis. Kementerian Kesehatan Republik. https://www.tbindonesia.or.id/wp-content/uploads/2021/06/NSP-TB-2020-2024-Ind_Final_-BAHASA.pdf
Kiouri, D. P., Tsoupra, E., Peana, M., Perlepes, S. P., Stefanidou, M. E., & Chasapis, C. T. (2023). Multifunctional Role of Zinc in Human Health: an Update. EXCLI Journal, 22, 809-827. https://doi.org/10.17179/excli2023-6335
Kurniaji, I., Rudiyanto, W., & Windarti, I. (2023). Anemia in Tuberculosis Patients. Medical Profession Journal of Lampung, 13(1), 42-46. https://doi.org/10.53089/medula.v13i1.592
Maywald, M., & Rink, L. (2022). Zinc in Human Health and Infectious Diseases. Biomolecules, 12(12), 1748. https://doi.org/10.3390/biom12121748
Muhammad, P., Ahmad, M., Iqbal, S., Shah, M., Obaid, S., & Wadud, S. (2022). The Biochemical and Physiologic Effect of Zinc and Vitamin A Supplementation to Increase Cellular Immune Response of Pulmonary Tuberculosis Patients: A Systematic Review. Pakistan Journal of Chest Medicine, 28(2), 249–256. Retrieved from https://www.pjcm.net/index.php/pjcm/article/view/803
Nairz, M., & Weiss, G. (2020). Iron in Infection and Immunity. Molecular Aspects of Medicine, 75. https://doi.org/10.1016/j.mam.2020.100864
Nienaber, A., Uyoga, M. A., Dolman-Macleod, R., & Malan, L. (2023). Iron Status and Supplementation during Tuberculosis. Microorganisms. 11(3), 785. https://doi.org/10.3390/microorganisms11030785
Patel, D. G., Baral, T., Kurian, S. J., Malakapogu, P., Saravu, K., & Miraj, S. S. (2024). Nutritional Status in Patients with Tuberculosis and Diabetes Mellitus: A Comparative Observational Study. J Clin Tuberc Other Mycobact Dis, 35. https://doi.org/10.1016/j.jctube.2024.100428
Putri, E. I. S., Indriati, D. W., & Wahyunitisari, M. R. (2020). The Prevalence of Diabetes Mellitus among Hospitalized Tuberculosis Positive Cases in Hajj Hospital Surabaya. Malaysian Journal of Medicine and Health Sciences, 16(1), 235-239. https://scholar.unair.ac.id/en/publications/the-prevalence-of-diabetes-mellitus-among-hospitalized-tuberculos
Rodriguez, G. M., Sharma, N., Biswas, A., Sharma, N. (2022). The Iron Response of Mycobacterium tuberculosis and Its Implications for Tuberculosis Pathogenesis and Novel Therapeutics. Front Cell Infect Microbiol, 12. https://doi.org/10.3389/fcimb.2022.876667
Waworuntu, W., Tanoerahardjo, F. S., Mallongi, A., Ahmad, A., Amin, M., Djaharuddin, I., Bukhari, A., Tabri, N. A., Bahar, B., Hidayah, N., Halik, H., & Massi, M. N. (2023). Serum Iron Levels in Tuberculosis Patients and Household Contacts and its Association with Natural Resistance-Associated Macrophage Protein 1 Polymorphism and Expression. The Clinical Respiratory Journal, 17(9), 893–904. https://doi.org/10.1111/crj.13677
World Health Organization, (2022). Global Tuberculosis Report 2022. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022
Zolfaghari, B., Ghanbari, M., Musavi, H., Baghshahi, P. B., Taghikhani, M., & Pourfallah, F. (2021). Investigation of Zinc Supplement Impact on the Serum Biochemical Parameters in Pulmonary Tuberculosis: A Double Blinded Placebo Control Trial. Reports of Biochemistry & Molecular Biology, 10(2), 173–182. https://doi.org/10.52547/rbmb.10.2.173
Ahmad, R., Shaju, R., Atfi, A., & Razzaque, M. S. (2024). Zinc and Diabetes: A Connection between Micronutrient and Metabolism. Cells, 13(16), 1359. https://doi.org/10.3390/cells13161359
Amelia, S., & Kaswandani, N. (2024). Correlation between Tuberculosis Type and Comorbidities with Nutritional Recovery Rates Post-Tuberculosis Treatment in Pediatric Patients. Archives of Pediatric Gastroenterology, Hepatology, and Nutrition,3(3), 1-11. https://doi.org/10.58427/apghn.3.3.2024.1-11
Barman, N., Khan, M. M. H., Ghosh, D., Towhid, M. I. I., Uddin, M. N., Paul, D., Haque, M. A. (2021). Serum Zinc Level and its Association with Multidrug-Resistant Tuberculosis. International Journal of Mycobacteriology, 10(2), 177-181. https://doi.org/10.4103/ijmy.ijmy_67_21
Bisht, M. K., & Dahiya, P. (2023). The Cause-Effect Relation of Tuberculosis on Incidence of Diabetes Mellitus. Front Cell Infect Microbiol.13, 1134036. https://doi.org/10.3389/fcimb.2023.1134036
Carin, V., Anwar, K., Irawati, S., & Maharani, Y. (2024). Asuhan Gizi pada Pasien Tuberkulosis Paru, Acute Lymphadenitis, dan Sindrom Nefrotik. Binawan Student Journal, 6(2), 144-152. https://doi.org/10.54771/57xj1a78
Caturano, A., D'Angelo, M., Mormone, A., Russo, V., Mollica, M. P., Salvatore, T., Galiero, R., Rinaldi, L., Vetrano, E., Marfella, R., Monda, M., Giordano, A., & Sasso, F. C. (2023). Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications. Current issues in molecular biology, 45(8), 6651–6666. https://doi.org/10.3390/cimb45080420
Fiorino, G., Colombel, J-F., Katsanos, K., Mearin, F., Stein, J., Andretta, M., Antonacci, S., Arenare, L., Citraro, R., Dell'Orco, S., Esposti, L. D., Serna, A. R. de A., Morin, N., & Koutroubakis, I. E. (2023). Iron Deficiency Anemia Impacts Disease Progression and Healthcare Resource Consumption in Patients with Inflammatory Bowel Disease: A Real-World Evidence Study. Therapeutic advances in gastroenterology, 16. https://doi.org/10.1177/17562848231177153
Hamed, A. M., Hadidy, K. E. S. E., & Salem, M. N. ( 2022). Ferritin as a Marker of Insulin Resistance in Diabetic Patients. Egyptian Journal of Medical Research. 3(2), 110-120. https://doi.org/10.21608/ejmr.2022.237765
Hasan, F. E., & Yunus, R. (2023). Antioxidant Function in Inhibiting Lipid Peroxidation and Increasing Erythrocyte Membrane Resistance in Diabetes Mellitus Patients. Health Information: Jurnal Penelitian, 15(2). https://doi.org/10.36990/hijp.v15i2.901
IDF. (2021). IDF Diabetes Atlas. https://www.diabetesatlas.org/data/en/country/94/id.html
Kemkes RI. (2020). Pedoman Nasional Pengendalian Tuberkulosis. Kementerian Kesehatan Republik. https://www.tbindonesia.or.id/wp-content/uploads/2021/06/NSP-TB-2020-2024-Ind_Final_-BAHASA.pdf
Kiouri, D. P., Tsoupra, E., Peana, M., Perlepes, S. P., Stefanidou, M. E., & Chasapis, C. T. (2023). Multifunctional Role of Zinc in Human Health: an Update. EXCLI Journal, 22, 809-827. https://doi.org/10.17179/excli2023-6335
Kurniaji, I., Rudiyanto, W., & Windarti, I. (2023). Anemia in Tuberculosis Patients. Medical Profession Journal of Lampung, 13(1), 42-46. https://doi.org/10.53089/medula.v13i1.592
Maywald, M., & Rink, L. (2022). Zinc in Human Health and Infectious Diseases. Biomolecules, 12(12), 1748. https://doi.org/10.3390/biom12121748
Muhammad, P., Ahmad, M., Iqbal, S., Shah, M., Obaid, S., & Wadud, S. (2022). The Biochemical and Physiologic Effect of Zinc and Vitamin A Supplementation to Increase Cellular Immune Response of Pulmonary Tuberculosis Patients: A Systematic Review. Pakistan Journal of Chest Medicine, 28(2), 249–256. Retrieved from https://www.pjcm.net/index.php/pjcm/article/view/803
Nairz, M., & Weiss, G. (2020). Iron in Infection and Immunity. Molecular Aspects of Medicine, 75. https://doi.org/10.1016/j.mam.2020.100864
Nienaber, A., Uyoga, M. A., Dolman-Macleod, R., & Malan, L. (2023). Iron Status and Supplementation during Tuberculosis. Microorganisms. 11(3), 785. https://doi.org/10.3390/microorganisms11030785
Patel, D. G., Baral, T., Kurian, S. J., Malakapogu, P., Saravu, K., & Miraj, S. S. (2024). Nutritional Status in Patients with Tuberculosis and Diabetes Mellitus: A Comparative Observational Study. J Clin Tuberc Other Mycobact Dis, 35. https://doi.org/10.1016/j.jctube.2024.100428
Putri, E. I. S., Indriati, D. W., & Wahyunitisari, M. R. (2020). The Prevalence of Diabetes Mellitus among Hospitalized Tuberculosis Positive Cases in Hajj Hospital Surabaya. Malaysian Journal of Medicine and Health Sciences, 16(1), 235-239. https://scholar.unair.ac.id/en/publications/the-prevalence-of-diabetes-mellitus-among-hospitalized-tuberculos
Rodriguez, G. M., Sharma, N., Biswas, A., Sharma, N. (2022). The Iron Response of Mycobacterium tuberculosis and Its Implications for Tuberculosis Pathogenesis and Novel Therapeutics. Front Cell Infect Microbiol, 12. https://doi.org/10.3389/fcimb.2022.876667
Waworuntu, W., Tanoerahardjo, F. S., Mallongi, A., Ahmad, A., Amin, M., Djaharuddin, I., Bukhari, A., Tabri, N. A., Bahar, B., Hidayah, N., Halik, H., & Massi, M. N. (2023). Serum Iron Levels in Tuberculosis Patients and Household Contacts and its Association with Natural Resistance-Associated Macrophage Protein 1 Polymorphism and Expression. The Clinical Respiratory Journal, 17(9), 893–904. https://doi.org/10.1111/crj.13677
World Health Organization, (2022). Global Tuberculosis Report 2022. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022
Zolfaghari, B., Ghanbari, M., Musavi, H., Baghshahi, P. B., Taghikhani, M., & Pourfallah, F. (2021). Investigation of Zinc Supplement Impact on the Serum Biochemical Parameters in Pulmonary Tuberculosis: A Double Blinded Placebo Control Trial. Reports of Biochemistry & Molecular Biology, 10(2), 173–182. https://doi.org/10.52547/rbmb.10.2.173
Published
2024-12-30
Section
Articles
Copyright (c) 2024 Aminahtun Latifah, Dewi Kurniasih, Evi Wahyuni
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
