Latihan Fisik terhadap Penurunan Cancer Related Fatigue pada Pasien Kanker Payudara
Abstract
This study aims to identify and evaluate the effect of a physical exercise intervention on reducing cancer-related fatigue in breast cancer patients. The method used is Systematic Reviews using EBSCO, PubMed and ProQuest databases. The articles were selected using the PRISMA (Preferred Items for Systematic Reviews and Meta-Analyses) diagram, which found ten articles that matched the inclusion criteria. The results showed that physical exercise had a significant effect on reducing fatigue and could improve the quality of life of breast cancer patients. In conclusion, physical exercise intervention can help relieve symptoms and reduce cancer-related fatigue in breast cancer patients.
Keywords: Cancer Related Fatigue, Breast Cancer, Physical Exercise
References
Abrahams, H. J. G., Gielissen, M. F. M., Verhagen, C. A. H. H. V. M., & Knoop, H. (2018). The Relationship of Fatigue in Breast Cancer Survivors with Quality of Life and Factors to Address in Psychological Interventions: A Systematic Review. Clinical Psychology Review, 63, 1–11. https://doi.org/10.1016/j.cpr.2018.05.004
Allemani, C., Matsuda, T., Di Carlo, V., Harewood, R., Matz, M., Nikšić, M., Bonaventure, A., Valkov, M., Johnson, C. J., Estève, J., Ogunbiyi, O. J., Azevedo e Silva, G., Chen, W. Q., Eser, S., Engholm, G., Stiller, C. A., Monnereau, A., Woods, R. R., Visser, O., Lewis, C. (2018). Global Surveillance of Trends in Cancer Survival 2000–14 (CONCORD-3): Analysis of Individual Records for 37 513 025 Patients Diagnosed With One of 18 Cancers from 322 Population-Based Registries In 71 Countries. The Lancet, 391(10125), 1023–1075. https://doi.org/10.1016/S0140-6736(17)33326-3
An, K. Y., Morielli, A. R., Kang, D. W., Friedenreich, C. M., McKenzie, D. C., Gelmon, K., Mackey, J. R., Reid, R. D., & Courneya, K. S. (2020). Effects of Exercise Dose and Type during Breast Cancer Chemotherapy on Longer-Term Patient-Reported Outcomes and Health-Related Fitness: A Randomized Controlled Trial. International Journal of Cancer, 146(1), 150–160. https://doi.org/10.1002/ijc.32493
Aydin, M., Kose, E., Odabas, I., Bingul, B. M., Demirci, D., & Aydin, Z. (2021). The Effect of Exercise on Life Quality and Depression Levels of Breast Cancer Patients. Asian Pacific Journal of Cancer Prevention, 22(3), 725–732. https://doi.org/10.31557/APJCP.2021.22.3.725
Baixauli, E. (2017). Happiness: Role of Dopamine and Serotonin on Mood and Negative Emotions. Emergency Medicine: Open Access, 7(2). https://doi.org/10.4172/2165-7548.1000350
Cohen, J., Rogers, W. A., Petruzzello, S., Trinh, L., & Mullen, S. P. (2021). Acute Effects of Aerobic Exercise and Relaxation Training on Fatigue in Breast Cancer Survivors: A Feasibility Trial. Psycho-Oncology, 30(2), 252–259. https://doi.org/10.1002/pon.5561
Duzova, H., Gullu, E., Cicek, G., Koksal, B. K., Kayhan, B., Gullu, A., & Sahin, I. (2018). The Effect Of Exercise Induced Weight-Loss On Myokines And Adipokines in Overweight Sedentary Females: Steps-Aerobics Vs. Jogging-Walking Exercises. Journal of Sports Medicine and Physical Fitness, 58(3), 295–308. https://doi.org/10.23736/S0022-4707.16.06565-8
Ehlers, D. K., DuBois, K., & Salerno, E. A. (2020). The Effects of Exercise on Cancer-Related Fatigue in Breast Cancer Patients During Primary Treatment: A Meta-Analysis and Systematic Review. Expert Review of Anticancer Therapy. https://doi.org/10.1080/14737140.2020.1813028
GBD. (2018). Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016. JAMA Oncology, 4(11), 1553–1568. https://doi.org/10.1001/jamaoncol.2018.2706
Huang, H. P., Wen, F. H., Yang, T. Y., Lin, Y. C., Tsai, J. C., Shun, S. C., Jane, S. W., & Chen, M. L. (2019). The Effect of a 12-Week Home-Based Walking Program on Reducing Fatigue in Women with Breast Cancer Undergoing Chemotherapy: A Randomized Controlled Study. International Journal of Nursing Studies, 99(259), 1-9. https://doi.org/10.1016/j.ijnurstu.2019.06.007
Jaime-Lara, R. B., Koons, B. C., Matura, L. A., Hodgson, N. A., & Riegel, B. (2017). A Qualytative Metasinthesys of Experience of Fatigue Across Five Chronic Conditions HHS Public Access. Physiology & Behavior, 176(3), 139–148. https://doi.org/10.1016/j.jpainsymman.2019.12.358.A
Maldonado et al. (2019). Effects of a 12-Week Resistance and Aerobic Exercise Program on Muscular Strength and Quality of Life in Breast Cancer Survivors: Study Protocol for the EFICAN Randomized Controlled Trial. Medicine, 98(44), e17625. https://doi.org/10.1097/MD.0000000000017625
Mostafaei, F., Azizi, M., Jalali, A., Salari, N., & Abbasi, P. (2021). Effect of Exercise on Depression and Fatigue in Breast Cancer Women Undergoing Chemotherapy: A Randomized Controlled Trial. Heliyon, 7(7), e07657. https://doi.org/10.1016/j.heliyon.2021.e07657
Mulhaeriah, Afiyanti, Y., Achmad, E. K., & Sangkala, M. S. (2018). Effectiveness of Relaxation Breathing Exercise on Fatigue in Gynecological Cancer Patients Undergoing Chemotherapy. International Journal of Nursing Sciences, 5(4), 331–335. https://doi.org/10.1016/j.ijnss.2018.09.004
Paulo, T. R. S., Rossi, F. E., Viezel, J., Tosello, G. T., Seidinger, S. C., Simões, R. R., De Freitas, R., & Freitas, I. F. (2019). The Impact of an Exercise Program on Quality of Life in Older Breast Cancer Survivors Undergoing Aromatase Inhibitor Therapy: A Randomized Controlled Trial. Health and Quality of Life Outcomes, 17(1), 1–13. https://doi.org/10.1186/s12955-019-1090-4
Poort, H., Peters, M. E. W. J., van der Graaf, W. T. A., Nieuwkerk, P. T., van de Wouw, A. J., Nijhuis-van der Sanden, M. W. G., Bleijenberg, G., Verhagen, C. A. H. H. V. M., & Knoop, H. (2020). Cognitive Behavioral Therapy or Graded Exercise Therapy Compared with Usual Care for Severe Fatigue in Patients with Advanced Cancer During Treatment: A Randomized Controlled Trial. Annals of Oncology, 31(1), 115–122. https://doi.org/10.1016/j.annonc.2019.09.002
Ronkainen, N. J., Pesola, A. J., Tikkanen, O., & Brand, R. (2021). Continuity and Discontinuity of Sport and Exercise Type during the COVID-19 Pandemic. An Exploratory Study of Effects on Mood. Frontiers in Psychology, 12, 1–10. https://doi.org/10.3389/fpsyg.2021.622876
Twomey, R., Martin, T., Temesi, J., Culos-Reed, S. N., & Millet, G. Y. (2018). Tailored Exercise Interventions To Reduce Fatigue In Cancer Survivors: Study Protocol of a Randomized Controlled Trial. BMC Cancer, 18(1), 1–19. https://doi.org/10.1186/s12885-018-4668-z
Van Vulpen, J. K., Sweegers, M. G., Peeters, P. H. M., Courneya, K. S., Newton, R. U., Aaronson, N. K., Jacobsen, P. B., Galvaõ, D. A., Chinapaw, M. J., Steindorf, K., Irwin, M. L., Stuiver, M. M., Hayes, S., Griffith, K. A., Mesters, I., Knoop, H., Goedendorp, M. M., Mutrie, N., Daley, A. J., McConnachie, A., Bohus, M., Thorsen, L., Schulz, K., Short, C. E., James, E. L., Plotnikoff, R. C., Schmidt, M. E., Ulrich, C. M., van Beurden, M., Oldenburg, H. S., Sonke, G. S., van Harten, W. H., Schmitz, K. H., Winters-Stone, K. M., Velthuis, M. J., Taaffe, D. R., van Mechelen, W., Kersten, M. J., Nollet, F., Wenzel, J., Wiskemann, J., Leeuw, I. M. V., Brug, J., May, A. M., & Buffart, L. M. (2020). Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data. Medicine and Science in Sports and Exercise, 52(2). https://doi.org/10.1249/MSS.0000000000002154
Voet, N. B. M., Van Der Kooi, E. L., Van Engelen, B. G. M., & Geurts, A. C. H. (2019). Strength Training and Aerobic Exercise Training for Muscle Disease. Cochrane Database of Systematic Reviews, 2019(12). https://doi.org/10.1002/14651858.CD003907.pub5
WHO. (2018). Incidence; Mortality and Prevalence by Cancer Site New. Globcon, 876, 1–2. https://gco.iarc.fr/today/home
Wu, W. W., Jou, S. T., Liang, S. Y., & Tsai, S. Y. (2019). The Mediating Role of Exercise on Relationships between Fatigue, Sleep Quality, and Quality of Life for Adolescents With Cancer. Cancer Nursing, 42(2), E10–E19. https://doi.org/10.1097/NCC.0000000000000585
Yee, J., Davis, G. M., Hackett, D., Beith, J. M., Wilcken, N., Currow, D., Emery, J., Phillips, J., Martin, A., Hui, R., Harrison, M., Segelov, E., & Kilbreath, S. L. (2019). Physical Activity for Symptom Management in Women with Metastatic Breast Cancer: A Randomized Feasibility Trial on Physical Activity and Breast Metastases. Journal of Pain and Symptom Management, 58(6), 929–939. https://doi.org/10.1016/j.jpainsymman.2019.07.022
Allemani, C., Matsuda, T., Di Carlo, V., Harewood, R., Matz, M., Nikšić, M., Bonaventure, A., Valkov, M., Johnson, C. J., Estève, J., Ogunbiyi, O. J., Azevedo e Silva, G., Chen, W. Q., Eser, S., Engholm, G., Stiller, C. A., Monnereau, A., Woods, R. R., Visser, O., Lewis, C. (2018). Global Surveillance of Trends in Cancer Survival 2000–14 (CONCORD-3): Analysis of Individual Records for 37 513 025 Patients Diagnosed With One of 18 Cancers from 322 Population-Based Registries In 71 Countries. The Lancet, 391(10125), 1023–1075. https://doi.org/10.1016/S0140-6736(17)33326-3
An, K. Y., Morielli, A. R., Kang, D. W., Friedenreich, C. M., McKenzie, D. C., Gelmon, K., Mackey, J. R., Reid, R. D., & Courneya, K. S. (2020). Effects of Exercise Dose and Type during Breast Cancer Chemotherapy on Longer-Term Patient-Reported Outcomes and Health-Related Fitness: A Randomized Controlled Trial. International Journal of Cancer, 146(1), 150–160. https://doi.org/10.1002/ijc.32493
Aydin, M., Kose, E., Odabas, I., Bingul, B. M., Demirci, D., & Aydin, Z. (2021). The Effect of Exercise on Life Quality and Depression Levels of Breast Cancer Patients. Asian Pacific Journal of Cancer Prevention, 22(3), 725–732. https://doi.org/10.31557/APJCP.2021.22.3.725
Baixauli, E. (2017). Happiness: Role of Dopamine and Serotonin on Mood and Negative Emotions. Emergency Medicine: Open Access, 7(2). https://doi.org/10.4172/2165-7548.1000350
Cohen, J., Rogers, W. A., Petruzzello, S., Trinh, L., & Mullen, S. P. (2021). Acute Effects of Aerobic Exercise and Relaxation Training on Fatigue in Breast Cancer Survivors: A Feasibility Trial. Psycho-Oncology, 30(2), 252–259. https://doi.org/10.1002/pon.5561
Duzova, H., Gullu, E., Cicek, G., Koksal, B. K., Kayhan, B., Gullu, A., & Sahin, I. (2018). The Effect Of Exercise Induced Weight-Loss On Myokines And Adipokines in Overweight Sedentary Females: Steps-Aerobics Vs. Jogging-Walking Exercises. Journal of Sports Medicine and Physical Fitness, 58(3), 295–308. https://doi.org/10.23736/S0022-4707.16.06565-8
Ehlers, D. K., DuBois, K., & Salerno, E. A. (2020). The Effects of Exercise on Cancer-Related Fatigue in Breast Cancer Patients During Primary Treatment: A Meta-Analysis and Systematic Review. Expert Review of Anticancer Therapy. https://doi.org/10.1080/14737140.2020.1813028
GBD. (2018). Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016. JAMA Oncology, 4(11), 1553–1568. https://doi.org/10.1001/jamaoncol.2018.2706
Huang, H. P., Wen, F. H., Yang, T. Y., Lin, Y. C., Tsai, J. C., Shun, S. C., Jane, S. W., & Chen, M. L. (2019). The Effect of a 12-Week Home-Based Walking Program on Reducing Fatigue in Women with Breast Cancer Undergoing Chemotherapy: A Randomized Controlled Study. International Journal of Nursing Studies, 99(259), 1-9. https://doi.org/10.1016/j.ijnurstu.2019.06.007
Jaime-Lara, R. B., Koons, B. C., Matura, L. A., Hodgson, N. A., & Riegel, B. (2017). A Qualytative Metasinthesys of Experience of Fatigue Across Five Chronic Conditions HHS Public Access. Physiology & Behavior, 176(3), 139–148. https://doi.org/10.1016/j.jpainsymman.2019.12.358.A
Maldonado et al. (2019). Effects of a 12-Week Resistance and Aerobic Exercise Program on Muscular Strength and Quality of Life in Breast Cancer Survivors: Study Protocol for the EFICAN Randomized Controlled Trial. Medicine, 98(44), e17625. https://doi.org/10.1097/MD.0000000000017625
Mostafaei, F., Azizi, M., Jalali, A., Salari, N., & Abbasi, P. (2021). Effect of Exercise on Depression and Fatigue in Breast Cancer Women Undergoing Chemotherapy: A Randomized Controlled Trial. Heliyon, 7(7), e07657. https://doi.org/10.1016/j.heliyon.2021.e07657
Mulhaeriah, Afiyanti, Y., Achmad, E. K., & Sangkala, M. S. (2018). Effectiveness of Relaxation Breathing Exercise on Fatigue in Gynecological Cancer Patients Undergoing Chemotherapy. International Journal of Nursing Sciences, 5(4), 331–335. https://doi.org/10.1016/j.ijnss.2018.09.004
Paulo, T. R. S., Rossi, F. E., Viezel, J., Tosello, G. T., Seidinger, S. C., Simões, R. R., De Freitas, R., & Freitas, I. F. (2019). The Impact of an Exercise Program on Quality of Life in Older Breast Cancer Survivors Undergoing Aromatase Inhibitor Therapy: A Randomized Controlled Trial. Health and Quality of Life Outcomes, 17(1), 1–13. https://doi.org/10.1186/s12955-019-1090-4
Poort, H., Peters, M. E. W. J., van der Graaf, W. T. A., Nieuwkerk, P. T., van de Wouw, A. J., Nijhuis-van der Sanden, M. W. G., Bleijenberg, G., Verhagen, C. A. H. H. V. M., & Knoop, H. (2020). Cognitive Behavioral Therapy or Graded Exercise Therapy Compared with Usual Care for Severe Fatigue in Patients with Advanced Cancer During Treatment: A Randomized Controlled Trial. Annals of Oncology, 31(1), 115–122. https://doi.org/10.1016/j.annonc.2019.09.002
Ronkainen, N. J., Pesola, A. J., Tikkanen, O., & Brand, R. (2021). Continuity and Discontinuity of Sport and Exercise Type during the COVID-19 Pandemic. An Exploratory Study of Effects on Mood. Frontiers in Psychology, 12, 1–10. https://doi.org/10.3389/fpsyg.2021.622876
Twomey, R., Martin, T., Temesi, J., Culos-Reed, S. N., & Millet, G. Y. (2018). Tailored Exercise Interventions To Reduce Fatigue In Cancer Survivors: Study Protocol of a Randomized Controlled Trial. BMC Cancer, 18(1), 1–19. https://doi.org/10.1186/s12885-018-4668-z
Van Vulpen, J. K., Sweegers, M. G., Peeters, P. H. M., Courneya, K. S., Newton, R. U., Aaronson, N. K., Jacobsen, P. B., Galvaõ, D. A., Chinapaw, M. J., Steindorf, K., Irwin, M. L., Stuiver, M. M., Hayes, S., Griffith, K. A., Mesters, I., Knoop, H., Goedendorp, M. M., Mutrie, N., Daley, A. J., McConnachie, A., Bohus, M., Thorsen, L., Schulz, K., Short, C. E., James, E. L., Plotnikoff, R. C., Schmidt, M. E., Ulrich, C. M., van Beurden, M., Oldenburg, H. S., Sonke, G. S., van Harten, W. H., Schmitz, K. H., Winters-Stone, K. M., Velthuis, M. J., Taaffe, D. R., van Mechelen, W., Kersten, M. J., Nollet, F., Wenzel, J., Wiskemann, J., Leeuw, I. M. V., Brug, J., May, A. M., & Buffart, L. M. (2020). Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data. Medicine and Science in Sports and Exercise, 52(2). https://doi.org/10.1249/MSS.0000000000002154
Voet, N. B. M., Van Der Kooi, E. L., Van Engelen, B. G. M., & Geurts, A. C. H. (2019). Strength Training and Aerobic Exercise Training for Muscle Disease. Cochrane Database of Systematic Reviews, 2019(12). https://doi.org/10.1002/14651858.CD003907.pub5
WHO. (2018). Incidence; Mortality and Prevalence by Cancer Site New. Globcon, 876, 1–2. https://gco.iarc.fr/today/home
Wu, W. W., Jou, S. T., Liang, S. Y., & Tsai, S. Y. (2019). The Mediating Role of Exercise on Relationships between Fatigue, Sleep Quality, and Quality of Life for Adolescents With Cancer. Cancer Nursing, 42(2), E10–E19. https://doi.org/10.1097/NCC.0000000000000585
Yee, J., Davis, G. M., Hackett, D., Beith, J. M., Wilcken, N., Currow, D., Emery, J., Phillips, J., Martin, A., Hui, R., Harrison, M., Segelov, E., & Kilbreath, S. L. (2019). Physical Activity for Symptom Management in Women with Metastatic Breast Cancer: A Randomized Feasibility Trial on Physical Activity and Breast Metastases. Journal of Pain and Symptom Management, 58(6), 929–939. https://doi.org/10.1016/j.jpainsymman.2019.07.022
