Ekstrak Labu Siam (Sechium edule) Dapat Menurunkan Kadar Serum Malondialdehid pada Tikus Putih (Rattus norvegicus) yang Diberikan Pakan Kolesterol

  • Maria Eka Patri Yulianti Universitas Bengkulu
  • Elvira Yunita Universitas Bengkulu
  • Zhafran Hafizhki Universitas Bengkulu
  • Meiny Suzery Universitas Diponegoro
  • Neni Susilaningsih Universitas Diponegoro
  • Suhartono Suhartono Universitas Diponegoro

Abstract

This study aimed to analyze the effect of chayote extract (Sechium edule) on malondialdehyde serum levels in white rats (Rattus norvegicus) fed a high-cholesterol diet and to prove the antioxidant content of chayote. The method used is experimental with a post-test-only control group design. This study used white rats, which were divided into five groups. The results of this study indicate that the administration of chayote extract at a dose of 0.25 g/kg BW and 0.5 g/kg BW can reduce the serum MDA concentration, although it is not statistically significant, while the administration of a chayote extract at a dose of 0.75 g/Kg BW can significantly reduce serum MDA levels in white rats induced by hypercholesterolemia. In conclusion, chayote extract at a dose of 0.75 g/kg BW can reduce blood MDA serum levels in white rats induced by hypercholesterolemia.

Keywords: Chayote Extract, Hypercholesterolemia, Malondialdehyde

References

D’Erasmo, L., Di Costanzo, A., & Arca, M. (2020). Autosomal Recessive Hypercholesterolemia: Update for 2020. Current Opinion in Lipidology, 31(2), 56–61. https://doi.org/10.1097/MOL.0000000000000664

Daulay, A. S., Ridwanto, Syahputra, R. A., & Nafitri, A. (2021). Antioxidant Activity Test of Chayote (Sechium edule (Jacq.) Swartz) Ethanol Extract Using DPPH Method. Journal of Physics: Conference Series, 1819(1). https://doi.org/10.1088/1742-6596/1819/1/012035

Dhakal, S., Kumar, S., & Singh, U. N. (2017). Study of Oxidative Stress in Hypercholesterolemia. International Journal of Contemporary Medical Research, 4(5), 2454–7379. https://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_1480_jun_17.pdf

Faris, M. (2020). Potensi Immunodulator Ekstrak Cengkeh pada Kadar Limfosit dan Makrofag sebagai Mekanisme Pertahanan Tubuh. Khazanah: Jurnal Mahasiswa, 12(1), 33–40. https://doi.org/10.20885/khazanah.vol12.iss1.art8

Fitriani, D., Hasbie, N. F., & Fuadiyah, Z. (2021). Studi Literatur Pengaruh Pemberian Ekstrak Kemangi (Ocimum basilicum L.) terhadap Kadar Kolesterol Total pada Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diberi Diet Tinggi Lemak. Jurnal Ilmu Kedokteran dan Kesehatan, 8(2), 173-180. https://doi.org/10.33024/jikk.v8i2.4258

Hardiany, N. S., Sucitra, S., & Paramita, R. (2020). Profile of Malondialdehyde (MDA) and Catalase Specific Activity in Plasma of Elderly Woman. Health Science Journal of Indonesia, 10(2), 132–136. https://doi.org/10.22435/hsji.v12i2.2239

Lestari, P., Marlina, D., & Rusmini, H. (2019). Pengaruh Flavanoid dalam Ekstrak Mentimun (Cucumis sativus L) terhadap Kadar Kolesterol Total Darah Mencit (Mus musculus L) yang Mengkonsumsi Makanan Cepat Saji. Jurnal Ilmu Kedokteran dan Kesehatan, 6(3), 166–175. https://doi.org/10.33024/jikk.v6i3.2087

Maurya, R. P., Prajapat, M. K., Singh, V. P., Roy, M., Todi, R., Bosak, S., Singh, S. K., Chaudhary, S., Kumar, A., & Morekar, S. R. (2021). Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy. Clinical Ophthalmology, 15, 871–879. https://doi.org/10.2147/OPTH.S287747

Millar, C. L., Duclos, Q., & Blesso, C. N. (2017). Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL Function. Advances in Nutrition, 8(2), 226–239. https://doi.org/10.3945/an.116.014050

Siahaan, J. M., Anto, E. J., & Fauzi, T. M. (2021). The Effects of Ethanol Extract, Chayote (Sechium edule (Jacq.) Swartz) Fraction and Juice on the High-density Lipoprotein Level in Male White Mice. Indonesian Journal of Medicine, 6(2), 145–151. https://doi.org/10.26911/theijmed.2021.06.02.03

Wilyanti, W., Kurniasari, F. N., & Harti, L. B. (2019). Pengaruh Seduhan Tepung Kulit Mangga Manalagi (Mangifera indica L.) terhadap Kadar MDA pada Tikus. Jurnal Kedokteran Brawijaya, 30(4), 235-239. https://doi.org/10.21776/ub.jkb.2019.030.04.1

Zhong, V. W., Van Horn, L., Cornelis, M. C., Wilkins, J. T., Ning, H., Carnethon, M. R., Greenland, P., Mentz, R. J., Tucker, K. L., Zhao, L., Norwood, A. F., Lloyd-Jones, D. M., & Allen, N. B. (2019). Associations of Dietary Cholesterol or Egg Consumption with Incident Cardiovascular Disease and Mortality. JAMA - Journal of the American Medical Association, 321(11), 1081–1095. https://doi.org/10.1001/jama.2019.1572
Published
2022-03-14
How to Cite
Yulianti, M., Yunita, E., Hafizhki, Z., Suzery, M., Susilaningsih, N., & Suhartono, S. (2022). Ekstrak Labu Siam (Sechium edule) Dapat Menurunkan Kadar Serum Malondialdehid pada Tikus Putih (Rattus norvegicus) yang Diberikan Pakan Kolesterol. Journal of Telenursing (JOTING), 4(1), 128-134. https://doi.org/https://doi.org/10.31539/joting.v4i1.3587
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