Penggunaan Madu terhadap Perbaikan Kondisi Klinis dalam Proses Penyembuhan Luka pada Pasien Ulkus Diabetikum
DOI:
https://doi.org/10.31539/joting.v6i2.4142Abstract
This study aims to identify the effectiveness of using honey in increasing the clinical improvement of diabetic ulcers in the wound healing process. The method used is a systematic review by searching research journals in databases, namely Embase, Scopus, PubMed and Proquest with the year of publication of the article starting from 2006-2021. Data analysis was carried out by taking relevant articles in this research, totaling 9 articles. The research results showed that the majority, namely 8 articles (89%), proved the effectiveness of honey in the wound healing process. Conclusion: The use of honey in wound care management has been proven to accelerate the healing process, reduce odor, clean wounds, stimulate granulation, and control infection.
Keywords: Diabetic Ulcer, Honey, Wound Healing
References
Agarwal, S., Bhardwaj, V., Singh, A., Goel, S., Bharat, M., & Krishna, J. A. I. (2015). a Control Clinical Trial of Honey-Impregnated and Povidone Iodine Dressings in the Treatment of Diabetic Foot Ulcers Among Northern Indian Subjects. International Wound Journal, 6(2), 7–10. https://www.researchgate.net/publication/289519432_
Al Saeed, M. (2013). Therapeutic Efficacy of Conventional Treatment Combined with Manuka Honey in the Treatment of Patients with Diabetic Foot Ulcers : A Randomized Controlled Study. The Egyptian Journal of Hospital Medicine, 53(October), 1064–1071. https://doi.org/10.12816/0001668
Gulati, S., Qureshi, A., Srivastava, A., Kataria, K., Kumar, P., & Ji, A. B. (2014). A Prospective Randomized Study to Compare the Effectiveness of Honey Dressing vs. Povidone Iodine Dressing in Chronic Wound Healing. Indian Journal of Surgery, 76(3), 193–198. https://doi.org/10.1007/s12262-012-0682-6
Hixon, K. R., Klein, R. C., Eberlin, C. T., Linder, H. R., Ona, W. J., Gonzalez, H., & Sell, S. A. (n.d.). A Critical Review and Perspective of Honey in Tissue Engineering and Clinical Wound Healing. https://doi.org/10.1089/wound.2018.0848
International Diabetes Federation.(2021). Diabetes Atlas (10th ed). International Diabetes Federation; 2021. https://diabetesatlas.org/idfawp/resourcefiles/2021/07/IDF_Atlas_10th_Edition_2021.pdf
Imran, M., Hussain, M. B., & Baig, M. (2015). A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 25(10), 721–725. https://doi.org/10.2015/JCPSP.721725
Kamaratos, A. V., Tzirogiannis, K. N., Iraklianou, S. A., Panoutsopoulos, G. I., Kanellos, I. E., & Melidonis, A. I. (2014). Manuka Honey-Impregnated Dressings in The Treatment of Neuropathic Diabetic Foot Ulcers. International Wound Journal, 11(3), 259–263. https://doi.org/10.1111/j.1742-481X.2012.01082.x
Karadeniz, E. Y., & Serin, E. K. (2023). Corrigendum to “Use of honey in diabetic foot ulcer: Systematic review and meta-analysis” [J Tissue Viability 32 (2023) 270–278, (S0965206X23000359), (10.1016/j.jtv.2023.03.002)]. Journal of Tissue Viability, 32(3), 449. https://doi.org/10.1016/j.jtv.2023.05.001
Karimi, Z., Behnammoghadam, M., Rafiei, H., Abdi, N., Zoladl, M., Talebianpoor, M. S., Arya, A., & Khastavaneh, M. (2019). Impact of Olive Oil and Honey on Healing of Diabetic Foot: A Randomized Controlled Trial. Clinical, Cosmetic and Investigational Dermatology, 12, 347–354. https://doi.org/10.2147/CCID.S198577
Kefani, P. E. P., Putra, I. B. A. D., & Roosseno, R. R. N. (2018). Honey Clinically Stimulates Granulation and Epithelialization in Chronic Wounds: A Report of Two Cases. Medical Journal of Indonesia, 27(1), 62–68. https://doi.org/10.13181/mji.v27i1.1457
Kementerian Kesehatan RI. (2018). Hasil Utama Riset Kesehatan Dasar 2018. https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil- riskesdas-2018_1274.pdf
Nair, H. K. R., Tatavilis, N., Pospíšilová, I., Kučerová, J., & Cremers, N. A. J. (2020). Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series. Antibiotics, 9(9), 1–12. https://doi.org/10.3390/antibiotics9090529
Reddy, D. M. V., Inamdar, D. P., & Mahesh, D. G. (2019). A Comparative Study of Topical Sucralfate Versus Honey Dressing in The Management of Diabetic Foot Ulcer. Surgical Update: International Journal of Surgery and Orthopedics, 5(4), 246–252. https://doi.org/10.17511/ijoso.2019.i04.03
Siavash, M., Shokri, S., Haghighi, S., Shahtalebi, M. A., & Farajzadehgan, Z. (2015). The Efficacy of Topical Royal Jelly on Healing of Diabetic Foot Ulcers: A Double-Blind Placebo-Controlled Clinical Trial. International Wound Journal, 12(2), 137–142. https://doi.org/10.1111/iwj.12063
Smith, D., Lane, R., McGinnes, R., O’Brien, J., Johnston, R., Bugeja, L., Team, V., & Weller, C. (2018). What Is The Effect of Exercise on Wound Healing in Patients with Venous Leg Ulcers? A Systematic Review. International Wound Journal, 15(3), 441–453. https://doi.org/10.1111/iwj.12885
Tashkandi, H. (2021). Honey in Wound Healing: An Updated Review. Open Life Sciences, 16(1), 1091–1100. https://doi.org/10.1515/BIOL-2021-0084
Tsang, K. K., Kwong, E. W. Y., To, T. S. S., Chung, J. W. Y., & Wong, T. K. S. (2017). A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer. Evidence-Based Complementary and Alternative Medicine, 2017. https://doi.org/10.1155/2017/5294890
Vyhlídalová, D., Kozáková, R., & Zeleníková, R. (2018). Management of Non-Healing Wounds with Honey Dressings: A Literature Review. Central European Journal of Nursing and Midwifery, 9(3), 880–888. https://doi.org/10.15452/CEJNM.2018.09.0019
Wang, C., Guo, M., Zhang, N., & Wang, G. (2019). Effectiveness of Honey Dressing in The Treatment of Diabetic Foot Ulcers: A Systematic Review And Meta-Analysis. Complementary therapies in clinical practice, 34, 123–131. https://doi.org/10.1016/j.ctcp.2018.09.004
Yilmaz, A. C., & Aygin, D. (2020). Honey Dressing in Wound Treatment: a Systematic Review. Complementary therapies in medicine, 51, 102388. https://doi.org/10.1016/j.ctim.2020.102388
Al Saeed, M. (2013). Therapeutic Efficacy of Conventional Treatment Combined with Manuka Honey in the Treatment of Patients with Diabetic Foot Ulcers : A Randomized Controlled Study. The Egyptian Journal of Hospital Medicine, 53(October), 1064–1071. https://doi.org/10.12816/0001668
Gulati, S., Qureshi, A., Srivastava, A., Kataria, K., Kumar, P., & Ji, A. B. (2014). A Prospective Randomized Study to Compare the Effectiveness of Honey Dressing vs. Povidone Iodine Dressing in Chronic Wound Healing. Indian Journal of Surgery, 76(3), 193–198. https://doi.org/10.1007/s12262-012-0682-6
Hixon, K. R., Klein, R. C., Eberlin, C. T., Linder, H. R., Ona, W. J., Gonzalez, H., & Sell, S. A. (n.d.). A Critical Review and Perspective of Honey in Tissue Engineering and Clinical Wound Healing. https://doi.org/10.1089/wound.2018.0848
International Diabetes Federation.(2021). Diabetes Atlas (10th ed). International Diabetes Federation; 2021. https://diabetesatlas.org/idfawp/resourcefiles/2021/07/IDF_Atlas_10th_Edition_2021.pdf
Imran, M., Hussain, M. B., & Baig, M. (2015). A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 25(10), 721–725. https://doi.org/10.2015/JCPSP.721725
Kamaratos, A. V., Tzirogiannis, K. N., Iraklianou, S. A., Panoutsopoulos, G. I., Kanellos, I. E., & Melidonis, A. I. (2014). Manuka Honey-Impregnated Dressings in The Treatment of Neuropathic Diabetic Foot Ulcers. International Wound Journal, 11(3), 259–263. https://doi.org/10.1111/j.1742-481X.2012.01082.x
Karadeniz, E. Y., & Serin, E. K. (2023). Corrigendum to “Use of honey in diabetic foot ulcer: Systematic review and meta-analysis” [J Tissue Viability 32 (2023) 270–278, (S0965206X23000359), (10.1016/j.jtv.2023.03.002)]. Journal of Tissue Viability, 32(3), 449. https://doi.org/10.1016/j.jtv.2023.05.001
Karimi, Z., Behnammoghadam, M., Rafiei, H., Abdi, N., Zoladl, M., Talebianpoor, M. S., Arya, A., & Khastavaneh, M. (2019). Impact of Olive Oil and Honey on Healing of Diabetic Foot: A Randomized Controlled Trial. Clinical, Cosmetic and Investigational Dermatology, 12, 347–354. https://doi.org/10.2147/CCID.S198577
Kefani, P. E. P., Putra, I. B. A. D., & Roosseno, R. R. N. (2018). Honey Clinically Stimulates Granulation and Epithelialization in Chronic Wounds: A Report of Two Cases. Medical Journal of Indonesia, 27(1), 62–68. https://doi.org/10.13181/mji.v27i1.1457
Kementerian Kesehatan RI. (2018). Hasil Utama Riset Kesehatan Dasar 2018. https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil- riskesdas-2018_1274.pdf
Nair, H. K. R., Tatavilis, N., Pospíšilová, I., Kučerová, J., & Cremers, N. A. J. (2020). Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series. Antibiotics, 9(9), 1–12. https://doi.org/10.3390/antibiotics9090529
Reddy, D. M. V., Inamdar, D. P., & Mahesh, D. G. (2019). A Comparative Study of Topical Sucralfate Versus Honey Dressing in The Management of Diabetic Foot Ulcer. Surgical Update: International Journal of Surgery and Orthopedics, 5(4), 246–252. https://doi.org/10.17511/ijoso.2019.i04.03
Siavash, M., Shokri, S., Haghighi, S., Shahtalebi, M. A., & Farajzadehgan, Z. (2015). The Efficacy of Topical Royal Jelly on Healing of Diabetic Foot Ulcers: A Double-Blind Placebo-Controlled Clinical Trial. International Wound Journal, 12(2), 137–142. https://doi.org/10.1111/iwj.12063
Smith, D., Lane, R., McGinnes, R., O’Brien, J., Johnston, R., Bugeja, L., Team, V., & Weller, C. (2018). What Is The Effect of Exercise on Wound Healing in Patients with Venous Leg Ulcers? A Systematic Review. International Wound Journal, 15(3), 441–453. https://doi.org/10.1111/iwj.12885
Tashkandi, H. (2021). Honey in Wound Healing: An Updated Review. Open Life Sciences, 16(1), 1091–1100. https://doi.org/10.1515/BIOL-2021-0084
Tsang, K. K., Kwong, E. W. Y., To, T. S. S., Chung, J. W. Y., & Wong, T. K. S. (2017). A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer. Evidence-Based Complementary and Alternative Medicine, 2017. https://doi.org/10.1155/2017/5294890
Vyhlídalová, D., Kozáková, R., & Zeleníková, R. (2018). Management of Non-Healing Wounds with Honey Dressings: A Literature Review. Central European Journal of Nursing and Midwifery, 9(3), 880–888. https://doi.org/10.15452/CEJNM.2018.09.0019
Wang, C., Guo, M., Zhang, N., & Wang, G. (2019). Effectiveness of Honey Dressing in The Treatment of Diabetic Foot Ulcers: A Systematic Review And Meta-Analysis. Complementary therapies in clinical practice, 34, 123–131. https://doi.org/10.1016/j.ctcp.2018.09.004
Yilmaz, A. C., & Aygin, D. (2020). Honey Dressing in Wound Treatment: a Systematic Review. Complementary therapies in medicine, 51, 102388. https://doi.org/10.1016/j.ctim.2020.102388
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2024-12-31
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Penggunaan Madu terhadap Perbaikan Kondisi Klinis dalam Proses Penyembuhan Luka pada Pasien Ulkus Diabetikum. (2024). Journal of Telenursing (JOTING), 6(2), 2897-2905. https://doi.org/10.31539/joting.v6i2.4142
