Penggunaan Madu terhadap Perbaikan Kondisi Klinis dalam Proses Penyembuhan Luka pada Pasien Ulkus Diabetikum
Abstract
This study aims to identify the effectiveness of using honey in increasing the clinical improvement of diabetic ulcers in the wound healing process. The method used is a systematic review by searching research journals in databases, namely Embase, Scopus, PubMed and Proquest with the year of publication of the article starting from 2006-2021. Data analysis was carried out by taking relevant articles in this research, totaling 9 articles. The research results showed that the majority, namely 8 articles (89%), proved the effectiveness of honey in the wound healing process. Conclusion: The use of honey in wound care management has been proven to accelerate the healing process, reduce odor, clean wounds, stimulate granulation, and control infection.
Keywords: Diabetic Ulcer, Honey, Wound Healing
References
Agarwal, S., Bhardwaj, V., Singh, A., Goel, S., Bharat, M., & Krishna, J. A. I. (2015). a Control Clinical Trial of Honey-Impregnated and Povidone Iodine Dressings in the Treatment of Diabetic Foot Ulcers Among Northern Indian Subjects. International Wound Journal, 6(2), 7–10. https://www.researchgate.net/publication/289519432_
Al Saeed, M. (2013). Therapeutic Efficacy of Conventional Treatment Combined with Manuka Honey in the Treatment of Patients with Diabetic Foot Ulcers : A Randomized Controlled Study. The Egyptian Journal of Hospital Medicine, 53(October), 1064–1071. https://doi.org/10.12816/0001668
Gulati, S., Qureshi, A., Srivastava, A., Kataria, K., Kumar, P., & Ji, A. B. (2014). A Prospective Randomized Study to Compare the Effectiveness of Honey Dressing vs. Povidone Iodine Dressing in Chronic Wound Healing. Indian Journal of Surgery, 76(3), 193–198. https://doi.org/10.1007/s12262-012-0682-6
Hixon, K. R., Klein, R. C., Eberlin, C. T., Linder, H. R., Ona, W. J., Gonzalez, H., & Sell, S. A. (n.d.). A Critical Review and Perspective of Honey in Tissue Engineering and Clinical Wound Healing. https://doi.org/10.1089/wound.2018.0848
International Diabetes Federation.(2021). Diabetes Atlas (10th ed). International Diabetes Federation; 2021. https://diabetesatlas.org/idfawp/resourcefiles/2021/07/IDF_Atlas_10th_Edition_2021.pdf
Imran, M., Hussain, M. B., & Baig, M. (2015). A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 25(10), 721–725. https://doi.org/10.2015/JCPSP.721725
Kamaratos, A. V., Tzirogiannis, K. N., Iraklianou, S. A., Panoutsopoulos, G. I., Kanellos, I. E., & Melidonis, A. I. (2014). Manuka Honey-Impregnated Dressings in The Treatment of Neuropathic Diabetic Foot Ulcers. International Wound Journal, 11(3), 259–263. https://doi.org/10.1111/j.1742-481X.2012.01082.x
Karadeniz, E. Y., & Serin, E. K. (2023). Corrigendum to “Use of honey in diabetic foot ulcer: Systematic review and meta-analysis” [J Tissue Viability 32 (2023) 270–278, (S0965206X23000359), (10.1016/j.jtv.2023.03.002)]. Journal of Tissue Viability, 32(3), 449. https://doi.org/10.1016/j.jtv.2023.05.001
Karimi, Z., Behnammoghadam, M., Rafiei, H., Abdi, N., Zoladl, M., Talebianpoor, M. S., Arya, A., & Khastavaneh, M. (2019). Impact of Olive Oil and Honey on Healing of Diabetic Foot: A Randomized Controlled Trial. Clinical, Cosmetic and Investigational Dermatology, 12, 347–354. https://doi.org/10.2147/CCID.S198577
Kefani, P. E. P., Putra, I. B. A. D., & Roosseno, R. R. N. (2018). Honey Clinically Stimulates Granulation and Epithelialization in Chronic Wounds: A Report of Two Cases. Medical Journal of Indonesia, 27(1), 62–68. https://doi.org/10.13181/mji.v27i1.1457
Kementerian Kesehatan RI. (2018). Hasil Utama Riset Kesehatan Dasar 2018. https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil- riskesdas-2018_1274.pdf
Nair, H. K. R., Tatavilis, N., Pospíšilová, I., Kučerová, J., & Cremers, N. A. J. (2020). Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series. Antibiotics, 9(9), 1–12. https://doi.org/10.3390/antibiotics9090529
Reddy, D. M. V., Inamdar, D. P., & Mahesh, D. G. (2019). A Comparative Study of Topical Sucralfate Versus Honey Dressing in The Management of Diabetic Foot Ulcer. Surgical Update: International Journal of Surgery and Orthopedics, 5(4), 246–252. https://doi.org/10.17511/ijoso.2019.i04.03
Siavash, M., Shokri, S., Haghighi, S., Shahtalebi, M. A., & Farajzadehgan, Z. (2015). The Efficacy of Topical Royal Jelly on Healing of Diabetic Foot Ulcers: A Double-Blind Placebo-Controlled Clinical Trial. International Wound Journal, 12(2), 137–142. https://doi.org/10.1111/iwj.12063
Smith, D., Lane, R., McGinnes, R., O’Brien, J., Johnston, R., Bugeja, L., Team, V., & Weller, C. (2018). What Is The Effect of Exercise on Wound Healing in Patients with Venous Leg Ulcers? A Systematic Review. International Wound Journal, 15(3), 441–453. https://doi.org/10.1111/iwj.12885
Tashkandi, H. (2021). Honey in Wound Healing: An Updated Review. Open Life Sciences, 16(1), 1091–1100. https://doi.org/10.1515/BIOL-2021-0084
Tsang, K. K., Kwong, E. W. Y., To, T. S. S., Chung, J. W. Y., & Wong, T. K. S. (2017). A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer. Evidence-Based Complementary and Alternative Medicine, 2017. https://doi.org/10.1155/2017/5294890
Vyhlídalová, D., Kozáková, R., & Zeleníková, R. (2018). Management of Non-Healing Wounds with Honey Dressings: A Literature Review. Central European Journal of Nursing and Midwifery, 9(3), 880–888. https://doi.org/10.15452/CEJNM.2018.09.0019
Wang, C., Guo, M., Zhang, N., & Wang, G. (2019). Effectiveness of Honey Dressing in The Treatment of Diabetic Foot Ulcers: A Systematic Review And Meta-Analysis. Complementary therapies in clinical practice, 34, 123–131. https://doi.org/10.1016/j.ctcp.2018.09.004
Yilmaz, A. C., & Aygin, D. (2020). Honey Dressing in Wound Treatment: a Systematic Review. Complementary therapies in medicine, 51, 102388. https://doi.org/10.1016/j.ctim.2020.102388
Al Saeed, M. (2013). Therapeutic Efficacy of Conventional Treatment Combined with Manuka Honey in the Treatment of Patients with Diabetic Foot Ulcers : A Randomized Controlled Study. The Egyptian Journal of Hospital Medicine, 53(October), 1064–1071. https://doi.org/10.12816/0001668
Gulati, S., Qureshi, A., Srivastava, A., Kataria, K., Kumar, P., & Ji, A. B. (2014). A Prospective Randomized Study to Compare the Effectiveness of Honey Dressing vs. Povidone Iodine Dressing in Chronic Wound Healing. Indian Journal of Surgery, 76(3), 193–198. https://doi.org/10.1007/s12262-012-0682-6
Hixon, K. R., Klein, R. C., Eberlin, C. T., Linder, H. R., Ona, W. J., Gonzalez, H., & Sell, S. A. (n.d.). A Critical Review and Perspective of Honey in Tissue Engineering and Clinical Wound Healing. https://doi.org/10.1089/wound.2018.0848
International Diabetes Federation.(2021). Diabetes Atlas (10th ed). International Diabetes Federation; 2021. https://diabetesatlas.org/idfawp/resourcefiles/2021/07/IDF_Atlas_10th_Edition_2021.pdf
Imran, M., Hussain, M. B., & Baig, M. (2015). A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 25(10), 721–725. https://doi.org/10.2015/JCPSP.721725
Kamaratos, A. V., Tzirogiannis, K. N., Iraklianou, S. A., Panoutsopoulos, G. I., Kanellos, I. E., & Melidonis, A. I. (2014). Manuka Honey-Impregnated Dressings in The Treatment of Neuropathic Diabetic Foot Ulcers. International Wound Journal, 11(3), 259–263. https://doi.org/10.1111/j.1742-481X.2012.01082.x
Karadeniz, E. Y., & Serin, E. K. (2023). Corrigendum to “Use of honey in diabetic foot ulcer: Systematic review and meta-analysis” [J Tissue Viability 32 (2023) 270–278, (S0965206X23000359), (10.1016/j.jtv.2023.03.002)]. Journal of Tissue Viability, 32(3), 449. https://doi.org/10.1016/j.jtv.2023.05.001
Karimi, Z., Behnammoghadam, M., Rafiei, H., Abdi, N., Zoladl, M., Talebianpoor, M. S., Arya, A., & Khastavaneh, M. (2019). Impact of Olive Oil and Honey on Healing of Diabetic Foot: A Randomized Controlled Trial. Clinical, Cosmetic and Investigational Dermatology, 12, 347–354. https://doi.org/10.2147/CCID.S198577
Kefani, P. E. P., Putra, I. B. A. D., & Roosseno, R. R. N. (2018). Honey Clinically Stimulates Granulation and Epithelialization in Chronic Wounds: A Report of Two Cases. Medical Journal of Indonesia, 27(1), 62–68. https://doi.org/10.13181/mji.v27i1.1457
Kementerian Kesehatan RI. (2018). Hasil Utama Riset Kesehatan Dasar 2018. https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil- riskesdas-2018_1274.pdf
Nair, H. K. R., Tatavilis, N., Pospíšilová, I., Kučerová, J., & Cremers, N. A. J. (2020). Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series. Antibiotics, 9(9), 1–12. https://doi.org/10.3390/antibiotics9090529
Reddy, D. M. V., Inamdar, D. P., & Mahesh, D. G. (2019). A Comparative Study of Topical Sucralfate Versus Honey Dressing in The Management of Diabetic Foot Ulcer. Surgical Update: International Journal of Surgery and Orthopedics, 5(4), 246–252. https://doi.org/10.17511/ijoso.2019.i04.03
Siavash, M., Shokri, S., Haghighi, S., Shahtalebi, M. A., & Farajzadehgan, Z. (2015). The Efficacy of Topical Royal Jelly on Healing of Diabetic Foot Ulcers: A Double-Blind Placebo-Controlled Clinical Trial. International Wound Journal, 12(2), 137–142. https://doi.org/10.1111/iwj.12063
Smith, D., Lane, R., McGinnes, R., O’Brien, J., Johnston, R., Bugeja, L., Team, V., & Weller, C. (2018). What Is The Effect of Exercise on Wound Healing in Patients with Venous Leg Ulcers? A Systematic Review. International Wound Journal, 15(3), 441–453. https://doi.org/10.1111/iwj.12885
Tashkandi, H. (2021). Honey in Wound Healing: An Updated Review. Open Life Sciences, 16(1), 1091–1100. https://doi.org/10.1515/BIOL-2021-0084
Tsang, K. K., Kwong, E. W. Y., To, T. S. S., Chung, J. W. Y., & Wong, T. K. S. (2017). A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer. Evidence-Based Complementary and Alternative Medicine, 2017. https://doi.org/10.1155/2017/5294890
Vyhlídalová, D., Kozáková, R., & Zeleníková, R. (2018). Management of Non-Healing Wounds with Honey Dressings: A Literature Review. Central European Journal of Nursing and Midwifery, 9(3), 880–888. https://doi.org/10.15452/CEJNM.2018.09.0019
Wang, C., Guo, M., Zhang, N., & Wang, G. (2019). Effectiveness of Honey Dressing in The Treatment of Diabetic Foot Ulcers: A Systematic Review And Meta-Analysis. Complementary therapies in clinical practice, 34, 123–131. https://doi.org/10.1016/j.ctcp.2018.09.004
Yilmaz, A. C., & Aygin, D. (2020). Honey Dressing in Wound Treatment: a Systematic Review. Complementary therapies in medicine, 51, 102388. https://doi.org/10.1016/j.ctim.2020.102388
Published
2024-12-31
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Copyright (c) 2024 Lia Novita Sari, Debie Dahlia, Dhika Ayu Kurnia
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