Perbedaan Kadar Pentraxin 3 pada Penderita Hepatitis B Kronis dengan Cirrosis dan Tanpa Cirrosis
Abstract
This study aims to see differences in pentraxin 3 levels in chronic hepatitis B sufferers with cirrosis and without cirrosis. The method uses cross sectional consecutive sampling. The results of this study found a significant difference between the average value of Pentraxin 3 in chronic Hepatitis B patients with liver cirrhosis group compared to the group without liver cirrhosis (p<0.001). There was a significant difference between the Pentraxin 3 levels in the group of Chronic Hepatitis B sufferers with liver cirrhosis compared to the group of Chronic Hepatitis B sufferers without liver cirrhosis (p<0.001) where the Pentraxin 3 levels in the Chronic Hepatitis B group with liver cirrhosis were higher compared to the group without liver cirrhosis. In conclusion, Pentraxin 3 levels can be used as an alternative marker to assess the development of liver cirrhosis in Chronic Hepatitis B patients.
Keywords: Chronic Hepatitis B, Liver cirrhosis, Pentraxin 3
References
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Zhou, J., Mao, W., Shen, L., & Huang, H. (2019). Plasma D-Dimer as a Novel Biomarker for Predicting Poor Outcomes in HBV-Related Decompensated Cirrhosis. Medicine, 98(52), e18257. https://doi.org/10.1097/md.0000000000018527
Feder, S., Haberl, E. M., Spirk, M., Weiss, T. S., Wiest, R., & Buechler, C. (2020). Pentraxin-3 is Not Related To Disease Severity in Cirrhosis and Hepatocellular Carcinoma Patients. Clinical and Experimental Medicine, 20(2), 289–297. https://doi.org/10.1007/s10238-020-00617-4
GadAllah, S., Badawy, H., Mohammed, E., Hassan, H., Ghait, S., & Ghait, R. (2022). Study of Plasma Pentraxin 3 Levels As a Novel Marker Versus Liver Stiffness for Nonalcoholic Steatohepatitis in Egyptian Patients. Ain Shams Medical Journal, 73(4), 763–772. https://doi.org/10.21608/asmj.2022.285439
Gupta, G., Mou, Z., Jia, P., Sharma, R., Zayats, R., Viana, S. M., Shan, L., Barral, A., Boaventura, V. S., Murooka, T. T., Soussi-Gounni, A., de Oliveira, C. I., & Uzonna, J. E. (2020). The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response. Cell Reports, 33(11), 108513. https://doi.org/10.1016/j.celrep.2020.108513
Han, Q., Deng, H., Fan, X., Wang, X., Zhang, X., Zhang, K., Li, N., Lv, Y., & Liu, Z. (2021). Increased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma, 8, 1367. https://doi.org/10.2147/jhc.s337936
Harjianti, T., & Setiawan, M. B. (2021). Angka Kejadian Hepatitis pada Pasien yang Menjalani Hemodialisa. Jurnal Kedokteran dan Kesehatan Wadi Husada, 07(2). https://jurnal.rsupwahidin.com/index.php/wadihusada/article/view/47/22
Hasa, E., Hartmann, P., & Schnabl, B. (2022). Liver Cirrhosis and Immune Dysfunction. International Immunology, 34(9), 455–466. https://doi.org/10.1093/intimm/dxac030
Hong, X., Luckenbaugh, L., Mendenhall, M., Walsh, R., Cabuang, L., Soppe, S., Revill, P. A., Burdette, D., Feierbach, B., Delaney, W., & Hu, J. (2021). Characterization of Hepatitis B Precore/Core-Related Antigens. Journal of Virology, 95(3), e01695-20. https://doi.org/10.1128/JVI.01695-20
Kementerian Kesehatan Republik Indonesia. (2020). Kebijakan dan Situasi Epidemiologi Hepatitis dan Penyakit Infeksi saluran Pencernaan di Indonesia. Kementerian Kesehatan Republik Indonesia. https://sihepi.kemkes.go.id/webportal/downloaddokumen/kie_hepb_c/hpisp_sihepi_15092020.pdf
Koffas, A., Petersen, J., & Kennedy, P. T. (2020). Reasons to Consider Early Treatment in Chronic Hepatitis B Patients. Antiviral Research, 177(March), 104783. https://doi.org/10.1016/j.antiviral.2020.104783
Lim, J. K., Nguyen, M. H., Kim, W. R., Gish, R., Perumalswami, P., & Jacobson, I. M. (2020). Prevalence of Chronic Hepatitis B Virus Infection in the United States. Official Journal of the American College of Gastroenterology| ACG, 115(9), 1429–1438. https://doi.org/10.14309/ajg.0000000000000651
Madihi, S., Madihi, S., Syed, H., Lazar, F., Zyad, A., & Benani, A. (2020). A Systematic Review of the Current Hepatitis B Viral Infection and Hepatocellular Carcinoma Situation in Mediterranean Countries. BioMed Research International, 2020. https://doi.org/10.1155/2020/7027169
Medzhitov, R. (2021). The Spectrum of Inflammatory Responses. Science, 374(6571), 1070–1075. https://doi.org/10.1126/SCIENCE.ABI5200
Pandyarajan, V., Govalan, R., & Yang, J. D. (2021). Risk Factors and Biomarkers for Chronic Hepatitis B Associated Hepatocellular Carcinoma. International journal of molecular sciences, 22(2), 479. https://doi.org/10.3390/ijms22020479
Sivasudhan, E., Blake, N., Lu, Z., Meng, J., & Rong, R. (2022). Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review. Cells, 11(4). https://doi.org/10.3390/cells11040741
Triana, D., Sinuhaji, B., Rambe, C. T., Asteria, M., & Yuliyanti, M. E. P. (2022). Analisis Faktor yang Berhubungan dengan Kejadian Hepatitis B pada Pendonor di Unit Transfusi Darah Kota Bengkulu. Jurnal Kesehatan Kusuma Husada, 13(1), 101–108. https://doi.org/10.34035/jk.v13i1.800
Vanwolleghem, T., Adomati, T., Van Hees, S., & Janssen, H. L. A. (2022). Humoral Immunity in Hepatitis B Virus Infection: Rehabilitating the B in HBV. JHEP Reports, 4(2), 100398. https://doi.org/10.1016/j.jhepr.2021.100398
Wang, G., Jiang, C., Fang, J., Li, Z., & Cai, H. (2022). Pentraxin-3 as a Predictive Marker of Mortality In Sepsis: An Updated Systematic Review and Meta-Analysis. Critical Care, 26(1), 1–12. https://doi.org/10.1186/s13054-022-04032-x
World Health Organization. (2023). Hepatitis. World Health Organization. https://www.who.int/health-topics/hepatitis#tab=tab_1
Zhou, J., Mao, W., Shen, L., & Huang, H. (2019). Plasma D-Dimer as a Novel Biomarker for Predicting Poor Outcomes in HBV-Related Decompensated Cirrhosis. Medicine, 98(52), e18257. https://doi.org/10.1097/md.0000000000018527
Published
2023-12-05
Section
Articles
Copyright (c) 2023 Afrianda Wira Sasmita, Taufik Sungkar, Ricke Loesnihari
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