Risiko Obesitas Efek Pengobatan Hipertiroid pada Pasien Hipertiroid
Abstract
This study aims to determine the risk of obesity and the effects of hyperthyroid treatment in hyperthyroid patients. The research method used is a systematic review through electronic databases and websites, namely ScienceDirect, Pubmed and Wiley Online Library. The research results showed that of the 7 research articles, 4 articles reported that hyperthyroidism treatment had an effect on the body, one of which was weight gain due to the disease. This needs to be controlled so that you don't become obese. There are articles stating that there is a lack of information about treatment options and their long-term consequences so that patients have no mechanism to predict these potential effects, namely weight gain that will lead to obesity. In conclusion, hyperthyroid patients undergoing treatment need to be given information about the drug therapy they are undergoing in order to reduce/avoid unwanted side effects, namely obesity.
Keywords: Hyperthyroid, Medication, Obesity, Obesity Risk, Thyroid Disease
References
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Alonso, G. T., Rabon, S., & White, P. (2018). Weight Gain After Treatment of Graves’ Disease in Children. Clin Endocrinol, 88(1), 66–70. https://doi.org/10.1111/cen.13493
Astuty, A. D., Achmad, G. N. V., Nita, Y., & Lestiono. (2020). Cost of Illness pada Pasien Diabetes Melitus dengan Diabetic Foot: Systematic Review. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 20–30. https://doi.org/10.20473/jfiki.v7i1si2020.20-30
Burch, H. B., & Cooper, D. S. (2015). Management of Graves Disease A Review. JAMA - Journal of the American Medical Association, 314(23), 2544–2554. https://doi.org/10.1001/jama.2015.16535
Cipolla, C., Graceffa, G., Calamia, S., Fiorentino, E., Pantuso, G., Vieni, S., & Latteri, M. (2019). The Value Of Total Thyroidectomy As The Definitive Treatment For Graves’ Disease: A Single Centre Experience Of 594 Cases. Journal of Clinical and Translational Endocrinology, 16, 1–5. https://doi.org/10.1016/j.jcte.2019.100183
Collares, F. M., Korevaar, T. I. M., Hofman, A., Steegers, E. A. P., Peeters, R. P., Jaddoe, V. W. V., & Gaillard, R. (2017). Maternal Thyroid Function, Prepregnancy Obesity And Gestational Weight Gain—The Generation R Study: A Prospective Cohort Study. Clinical Endocrinology, 87(6), 799–806. https://doi.org/10.1111/cen.13412
Das, D., Banerjee, A., Jena, A. B., Duttaroy, A. K., & Pathak, S. (2022). Essentiality, Relevance, and Efficacy of Adjuvant/Combinational Therapy in the Management of Thyroid Dysfunctions. Biomedicine and Pharmacotherapy, 146, 1–17. https://doi.org/10.1016/j.biopha.2022.112613
Devereaux, D., & Tewelde, S. Z. (2014). Hyperthyroidism and Thyrotoxicosis. Emergency Medicine Clinics of North America, 32(2), 277–292. https://doi.org/10.1016/j.emc.2013.12.001
Kelly, T. (2015). An Examination of Myth: A Favorable Cardiovascular Risk-Benefit Analysis of High-Dose Thyroid for Affective Disorders. Journal of Affective Disorders, 177, 49–58. https://doi.org/10.1016/j.jad.2015.01.016
Kyriacou, A. (2018). Thyroid and Weight. In Practical Guide to Obesity Medicine. Elsevier Inc. https://doi.org/10.1016/b978-0-323-48559-3.00005-1
Kyriacou, A., McLaughlin, J., & Syed, A. A. (2015). Thyroid Disorders and Gastrointestinal and Liver Dysfunction: A State of The Art Review. European Journal of Internal Medicine, 26(8), 563–571. https://doi.org/10.1016/j.ejim.2015.07.017
Pusat Data dan Informasi Kementerian Kesehatan RI. (2015). Situasi dan Analisis Penyakit Tiroid. https://pusdatin.kemkes.go.id/resources/download/pusdatin/infodatin/infodatin-tiroid.pdf
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Rotondi, M., Croce, L., Pallavicini, C., Manna, L. La, Accornero, S., Fonte, R., Magri, F., & Chiovato, L. (2014). Body weight changes in a large Body Weight Changes in A Large Cohort of Patients Subjected To Thyroidectomy For A Wide Spectrum of Thyroid Disease. Endocrine Practice, 20(11), 1151–1158. https://doi.org/10.4158/EP14125.OR
Rusda, H., Oenzil, F., & Alioes, Y. (2013). Hubungan Kadar Ft4 Dengan Kejadian Tirotoksikosis berdasarkan Penilaian Indeks New Castle Padawanita Dewasa di Daerah Ekses Yodium. Jurnal Kesehatan Andalas, 2(2), 85. https://doi.org/10.25077/jka.v2i2.126
Russo, L., Nguyen, T. N. H., Kyrilli, A., Robin, M., Lassen, P. B., Moreno-Reyes, R., & Corvilain, B. (2021). Metabolic Changes after Radioiodine Correction of Grade 1 and Grade 2 Subclinical Hyperthyroidism. European Thyroid Journal, 10(5), 382–389. https://doi.org/10.1159/000512734
Schneider, D. F., Nookala, R., Jaraczewski, T. J., Chen, H., Solorzano, C. C., & Sippel, R. S. (2014). Thyroidectomy as Primary Treatment Optimizes Body Mass Index in Patients with Hyperthyroidism. Annals of Surgical Oncology, 21(7), 2303–2309. https://doi.org/10.1245/s10434-014-3542-8
Sengupta, J., Das, H., Chellaiyan D, V. G., S, S., & Britto J, J. (2022). Incidence of Metabolic Syndrome in Patients With Graves’ Disease Under Control: A Observational Study. Clinical Epidemiology and Global Health, 15(August 2021), 101010. https://doi.org/10.1016/j.cegh.2022.101010
Torlinska, B., Hazlehurst, J. M., Nirantharakumar, K., Thomas, G. N., Priestley, J. R., Finnikin, S. J., Saunders, P., Abrams, K. R., & Boelaert, K. (2021). Weight changes, Cardio-Metabolic Risks and Mortality in Patients with Hyperthyroidism (EGRET): A Protocol for A CPRD-HES Linked Cohort Study. BMJ Open, 11(10), 1–8. https://doi.org/10.1136/bmjopen-2021-055219
Torlinska, B., Nichols, L., Mohammed, M. A., McCabe, C., & Boelaert, K. (2019). Patients Treated for Hyperthyroidism Are at Increased Risk of Becoming Obese: Findings from a Large Prospective Secondary Care Cohort. Thyroid, 29(10), 1–40. https://doi.org/10.1089/thy.2018.0731
Widyawigata, R. Z. G., Prajoko, Y. W., Mahati, E., & Adrianto, A. A. (2019). Tiroidektomi Meningkatkan IMT (Indeks Massa Tubuh) Pada Pasien Hipertiroid Di RSUP Dr. Kariadi Semarang. Jurnal Kedokteran Diponegoro, 8(4), 1225–1235. https://ejournal3.undip.ac.id/index.php/medico/article/view/25369/22512
Alonso, G. T., Rabon, S., & White, P. (2018). Weight Gain After Treatment of Graves’ Disease in Children. Clin Endocrinol, 88(1), 66–70. https://doi.org/10.1111/cen.13493
Astuty, A. D., Achmad, G. N. V., Nita, Y., & Lestiono. (2020). Cost of Illness pada Pasien Diabetes Melitus dengan Diabetic Foot: Systematic Review. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 20–30. https://doi.org/10.20473/jfiki.v7i1si2020.20-30
Burch, H. B., & Cooper, D. S. (2015). Management of Graves Disease A Review. JAMA - Journal of the American Medical Association, 314(23), 2544–2554. https://doi.org/10.1001/jama.2015.16535
Cipolla, C., Graceffa, G., Calamia, S., Fiorentino, E., Pantuso, G., Vieni, S., & Latteri, M. (2019). The Value Of Total Thyroidectomy As The Definitive Treatment For Graves’ Disease: A Single Centre Experience Of 594 Cases. Journal of Clinical and Translational Endocrinology, 16, 1–5. https://doi.org/10.1016/j.jcte.2019.100183
Collares, F. M., Korevaar, T. I. M., Hofman, A., Steegers, E. A. P., Peeters, R. P., Jaddoe, V. W. V., & Gaillard, R. (2017). Maternal Thyroid Function, Prepregnancy Obesity And Gestational Weight Gain—The Generation R Study: A Prospective Cohort Study. Clinical Endocrinology, 87(6), 799–806. https://doi.org/10.1111/cen.13412
Das, D., Banerjee, A., Jena, A. B., Duttaroy, A. K., & Pathak, S. (2022). Essentiality, Relevance, and Efficacy of Adjuvant/Combinational Therapy in the Management of Thyroid Dysfunctions. Biomedicine and Pharmacotherapy, 146, 1–17. https://doi.org/10.1016/j.biopha.2022.112613
Devereaux, D., & Tewelde, S. Z. (2014). Hyperthyroidism and Thyrotoxicosis. Emergency Medicine Clinics of North America, 32(2), 277–292. https://doi.org/10.1016/j.emc.2013.12.001
Kelly, T. (2015). An Examination of Myth: A Favorable Cardiovascular Risk-Benefit Analysis of High-Dose Thyroid for Affective Disorders. Journal of Affective Disorders, 177, 49–58. https://doi.org/10.1016/j.jad.2015.01.016
Kyriacou, A. (2018). Thyroid and Weight. In Practical Guide to Obesity Medicine. Elsevier Inc. https://doi.org/10.1016/b978-0-323-48559-3.00005-1
Kyriacou, A., McLaughlin, J., & Syed, A. A. (2015). Thyroid Disorders and Gastrointestinal and Liver Dysfunction: A State of The Art Review. European Journal of Internal Medicine, 26(8), 563–571. https://doi.org/10.1016/j.ejim.2015.07.017
Pusat Data dan Informasi Kementerian Kesehatan RI. (2015). Situasi dan Analisis Penyakit Tiroid. https://pusdatin.kemkes.go.id/resources/download/pusdatin/infodatin/infodatin-tiroid.pdf
Putra, B. F. K. (2017). Fibrilasi Atrium pada Hipertiroid. Cermin Dunia Kedokteran, 44(9), 619–621. http://www.cdkjournal.com/index.php/CDK/article/view/725
Rotondi, M., Croce, L., Pallavicini, C., Manna, L. La, Accornero, S., Fonte, R., Magri, F., & Chiovato, L. (2014). Body weight changes in a large Body Weight Changes in A Large Cohort of Patients Subjected To Thyroidectomy For A Wide Spectrum of Thyroid Disease. Endocrine Practice, 20(11), 1151–1158. https://doi.org/10.4158/EP14125.OR
Rusda, H., Oenzil, F., & Alioes, Y. (2013). Hubungan Kadar Ft4 Dengan Kejadian Tirotoksikosis berdasarkan Penilaian Indeks New Castle Padawanita Dewasa di Daerah Ekses Yodium. Jurnal Kesehatan Andalas, 2(2), 85. https://doi.org/10.25077/jka.v2i2.126
Russo, L., Nguyen, T. N. H., Kyrilli, A., Robin, M., Lassen, P. B., Moreno-Reyes, R., & Corvilain, B. (2021). Metabolic Changes after Radioiodine Correction of Grade 1 and Grade 2 Subclinical Hyperthyroidism. European Thyroid Journal, 10(5), 382–389. https://doi.org/10.1159/000512734
Schneider, D. F., Nookala, R., Jaraczewski, T. J., Chen, H., Solorzano, C. C., & Sippel, R. S. (2014). Thyroidectomy as Primary Treatment Optimizes Body Mass Index in Patients with Hyperthyroidism. Annals of Surgical Oncology, 21(7), 2303–2309. https://doi.org/10.1245/s10434-014-3542-8
Sengupta, J., Das, H., Chellaiyan D, V. G., S, S., & Britto J, J. (2022). Incidence of Metabolic Syndrome in Patients With Graves’ Disease Under Control: A Observational Study. Clinical Epidemiology and Global Health, 15(August 2021), 101010. https://doi.org/10.1016/j.cegh.2022.101010
Torlinska, B., Hazlehurst, J. M., Nirantharakumar, K., Thomas, G. N., Priestley, J. R., Finnikin, S. J., Saunders, P., Abrams, K. R., & Boelaert, K. (2021). Weight changes, Cardio-Metabolic Risks and Mortality in Patients with Hyperthyroidism (EGRET): A Protocol for A CPRD-HES Linked Cohort Study. BMJ Open, 11(10), 1–8. https://doi.org/10.1136/bmjopen-2021-055219
Torlinska, B., Nichols, L., Mohammed, M. A., McCabe, C., & Boelaert, K. (2019). Patients Treated for Hyperthyroidism Are at Increased Risk of Becoming Obese: Findings from a Large Prospective Secondary Care Cohort. Thyroid, 29(10), 1–40. https://doi.org/10.1089/thy.2018.0731
Widyawigata, R. Z. G., Prajoko, Y. W., Mahati, E., & Adrianto, A. A. (2019). Tiroidektomi Meningkatkan IMT (Indeks Massa Tubuh) Pada Pasien Hipertiroid Di RSUP Dr. Kariadi Semarang. Jurnal Kedokteran Diponegoro, 8(4), 1225–1235. https://ejournal3.undip.ac.id/index.php/medico/article/view/25369/22512
Published
2024-02-02
Section
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