Uji Toksisitas Akut Asam Askorbat Per Oral pada Organ Ginjal dan Hepar Tikus (Rattusnorvegicus) Betina Galur Wistar
Abstract
This study aims to determine the effects of acute toxicity of ascorbic acid on the kidney and liver organs of female Wistar rats. The method used in this study is an experimental method with a post-test only control group design model approach. The results showed that the average SGPT level was 61.24 ± 9.416 U / L. While the results of the mean value of blood serum creatinine levels were (1.48) (0.60 - 2.00) Based on bivariate analysis, there was no significant difference in the mean between the treatment and control groups (P <0.001). Acute administration of ascorbic acid at a dose of 9 mg / 200 grams of BW / day, 36 mg / 200 grams of BW / day, 72 mg / 200 grams of BW / day did not increase SGPT and blood creatinine levels in female Wistar rats. The results obtained using doses of 9 mg, 36 mg, 72 mg on toxicity were not too significant for the kidney and liver organs. Administration of ascorbic acid has an impact on SGPT (Serum Glutamic Pyruvic Transaminase) levels in the liver of mice. Doses of 9 mg, 36 mg, and 72 mg of ascorbic acid did not show significant toxicity effects on the kidneys and livers of mice.
Keywords: Ascorbic Acid, Creatinin Serum, SGPT.
References
Anjani, M. (2022). Uji Toksisitas Subkronik Kombinasi Daun Benalu Teh dan Benalu Mangga terhadap Fungsi Hepar Tikus (Rattus Norvegicus). Universitas Islam Negeri Maulana Malik Ibrahim Malang. http://etheses.uin-malang.ac.id/42658/
Arindani, P. D. N. (2023). Pengaruh Pemberian Krim Ekstrak Kacang Kedelai terhadap Kadar Matrix Metalloproteinase-1 (Mmp-1) Dan Interleukin-6 (Il-6). Universitas Islam Sultan Agung. https://repository.unissula.ac.id/33923/
Caritá, A. C., Fonseca-Santos, B., Shultz, J. D., Michniak-Kohn, B., Chorilli, M., & Leonardi, G. R. (2020). Vitamin C: One Compound, Several Uses. Advances for Delivery, Efficiency and Stability. Nanomedicine : Nanotechnology, Biology, And Medicine, 24. https://doi.org/10.1016/j.nano.2019.102117
Dewi, E. F. E., & Mahriani, M. (2023). The The Effect of Giving The Antioxidant Vitamin C in Tris-Egg Yolk Extender During The Preservation Period on The Quality of The Epididymal Spermatozoa of Mice (Mus Musculus L.). Berkala Sainstek, 11(4), 207. https://doi.org/10.19184/bst.v11i4.39109
Dhini, V. A. (N.D.). Masyarakat Indonesia Paling Banyak Konsumsi Vitamin C Saat Pandemi Covid-19. Retrieved January 25, 2024, From https://databoks.katadata.co.id/datapublish/2021/09/22/masyarakat-indonesia-paling-banyak-konsumsi-vitamin-c-saat-pandemi-covid-19
Dzakirah, I. (2021). Pengaruh Pemberian Vitamin C dalam Pengobatan Covid-19. Jurnal Medika Hutama, 3, 1633–1637. http://jurnalmedikahutama.com
Alquraisi, R. H. A., & Oktariani, O. L. (2021). A Literature Review: Aktivitas Imunomodulator Vitamin C. Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ), 4(1), 30-35. https://doi.org/10.35799/pmj.4.1.2021.34522
Hasanah, U., & Burhannudin, D. (2023). Evaluasi Nevirapine pada Terapi Arv Tahun Pertama dan Kedua terhadap Fungsi Hati di Puskesmas Kecamatan Cilandak: Studi Kadar Sgot Dan Sgpt. In Jurnal Fisioterapi Dan Kesehatan Indonesia, 3(2). https://doi.org/10.59946/jfki.2023.221
Hutasoit, J. I., & Kurniati, I. (2020). Pengaruh Suplementasi Zinc dan Vitamin C terhadap Pasien Malaria yang Anemia. Jurnal Medula, 10, 160–164. https://doi.org/10.14710/jgi.5.1.20-25
Kang, S., Lee, J., Choi, S., Nesbitt, J., Min, P. H., Trushina, E., & Choi, D.-S. (2023). Moderate Ethanol Exposure Reduces Astrocyte-Induced Neuroinflammatorysignaling and Cognitive Decline in Presymptomatic App/Ps1 Mice. Research Square. https://doi.org/10.21203/rs.3.rs-3627637/v1
Kashiouris, M. G., L’heureux, M., Cable, C. A., Fisher, B. J., Leichtle, S. W., & Fowler, A. A. (2020). The Emerging Role of Vitamin C As A Treatment for Sepsis. in Nutrients, 12(2). Mdpi Ag. https://doi.org/10.3390/nu12020292
Lozano-Sánchez, J., Borrás-Linares, I., Sass-Kiss, A., & Segura-Carretero, A. (2018). Chromatographic Technique: High-Performance Liquid Chromatography (Hplc). Modern Techniques for Food Authentication, 459–526. https://doi.org/10.1016/b978-0-12-814264-6.00013-x
Micho, W. R., Putri, J. A., Rahmi, Y., Diah, P. W., & Utomo, B. (2020). Antioxidant and Cytotoxic in Vitro Activities of Ananas Comosus Methanol Extract in T-47d Breast Cancer Cell Line. Jurnal Pangan dan Agroindustri, 8(2). https://doi.org/10.21776/ub.jpa.2020.008.02.5
Ningsih, S. A., Rusmini, H., Purwaningrum, R., & Zulfian, Z. (2021). Hubungan Kadar Kreatinin dengan Durasi Pengobatan Hd pada Penderita Gagal Ginjal Kronik. Jurnal Ilmiah Kesehatan Sandi Husada, 10(1), 202–207. https://doi.org/10.35816/jiskh.v10i1.581
Nurviana, V., Purwandi Sukmawan, Y., & Fauzan Roeswanto, G. (2022). Toksisitas Sub Kronik Fraksi Etil Asetat Biji Limus (Mangifera Foetida Lour.) terhadap Hepar dan Ginjal pada Tikus Putih Galur Wistar. Journal Of Pharmacopolium, 5(2). https://doi.org/10.36465/jop.v5i2.928
Rahayu, E. W., Nastiti, K., & Aryzki, S. (2024). Uji Efektivitas Ekstrak Daun Sungkai (Peronema Canescens Jack.) dari Desa Petuk Katimpun Kalimantan Tengah Sebagai Analgetik terhadap Tikus Putih Jantan (Rattus Norvegicus). Jurnal Surya Medika, 10(1), 253–260. https://doi.org/10.33084/jsm.v10i1.7206
Rindwitia, A., Peanasari, I., Djamil, S. L., & Rohmani, A. (2013). Pengaruh Formalin Peroral terhadap Kadar Sgot dan Sgpt Tikus Wistar. Jurnal Kedokteran Muhammadiyah, 2(1). https://doi.org/10.24843/jfu.2017.v06.i01.p06
Safnowand. (2022). Pemanfaatan Vitamin C Alami Sebagai Antioksidan pada Tubuh Manusia. Jurnal Kajian Biologi, 2, 6–13. https://e-journal.lp3kamandanu.com/index.php/biocaster/
Sutrisna, M. (2022). Pengaruh Penggunaan Terapi Adjuvant terhadap Kesembuhan Pasien Covid 19 : Studi Literature. Insologi: Jurnal Sains Dan Teknologi, 1(3), 291–299. https://doi.org/10.55123/insologi.v1i3.326
Vasques, F., Cavazza, A., & Bernal, W. (2022). Acute Liver Failure. Current Opinion In Critical Care, 28(2), 198–207. https://doi.org/10.1097/mcc.0000000000000923
Copyright (c) 2024 Ni Made Ayu Saraswati, Agung Wiwiek Indrayan, Agung Nova Mahendra, Wayan Sumardika
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
