Kandungan Antioksidan pada Suplemen Daun Kelor terhadap Kadar Acyl Ghrelin pada Subjek Obesitas
Keywords:
Acyl Ghrelin, Suplemen Daun Kelor, Antioksidan, Obesitas
Abstract
This study aims to explore the effect of antioxidant content on acyl ghrelin levels in obese subjects. This research method is a systematic literature review approach by searching for journal articles in the PubMed database. Inclusion criteria were articles published in the last 10 years using RCT methods on experimental animals and humans with obese nutritional status and providing Moringa leaf intervention. The research results showed that of 69 articles identified, only 7 articles met the inclusion criteria. The findings obtained indicate that the high antioxidant content of Moringa leaves has great potential as a functional food source and is beneficial for body health. The conclusion of the research is that the antioxidant content in Moringa leaves has an effect on obesity and still needs to be studied for its effect on acyl ghrelin.
Keywords: Acyl ghrelin, Moringa Leaf Supplements, Antioxidants, Obesity
References
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Denta, Anggeria Oktavisa, and Endang Fauziyah. (2022). Serbuk Daun Kelor Efektif Menurunkan Kadar Glukosa Darah Dan Kadar Kolesterol Pada Individu Obese. Wiraraja Medika: Jurnal Kesehatan 12(1): 10–16. https://doi.org/10.24929/fik.v12i1.1712
El-Shehawi, A. M., Alkafafy, M., El-Shazly, S., Sayed, S., Farouk, S., Alotaibi, S., ... & Ahmed, M. M. (2021). Moringa Oleifera Leaves Ethanolic Extract Ameliorates High Fat Diet-Induced Obesity in Rats. Journal of King Saud University-Science, 33(6), 101552. https://doi.org/10.1016/j.jksus.2021.101552
Farhadipour, M., & Depoortere, I. (2021). The Function of Gastrointestinal Hormones in Obesity—Implications for the Regulation of Energy Intake. Nutrients, 13(6), 1839. https://doi.org/10.3390/nu13061839
Gómez-Martínez, S., Díaz-Prieto, L. E., Castro, I. V., Jurado, C., Iturmendi, N., Martín-Ridaura, M. C., ... & Nova, E. (2021). Moringa Oleifera Leaf Supplementation As A Glycemic Control Strategy in Subjects with Prediabetes. Nutrients, 14(1), 57. .https://doi.org/10.3390/nu14010057
Hidayati, E. N., Kinanti, C. D., & Masrul, M. Z. (2023). Skrining Fitokimia dan Penentuan Kadar Flavonoid Total Ekstrak Etanol Daun Kelor (Moringa oleifera) Menggunakan Metode Spektrofotometer UV-Vis. JIKES: Jurnal Ilmu Kesehatan, 2(1), 14-21.http://qjurnal.my.id/index.php/jik/article/view/642
Kim, D. S., Choi, M. H., & Shin, H. J. (2020). Extracts of Moringa Oleifera Leaves from Different Cultivation Regions Show Both Antioxidant and Antiobesity Activities. Journal of Food Biochemistry, 44(7), e13282. https://doi.org/10.1111/jfbc.13282
Krisanti, S., Darwinata, A. E., & Jawi, I. M. (2023). Oral Administration of Ethanol Extract of Moringa Leaves (Moringa oleifera) Reduces F2-Isoprostane and Monocyte Chemoattractant Protein (MCP-1) Levels in Wistar Rats (Rattus norvegicus) as an Obesity Model. International Journal of Research and Review, 10(7), 12-18 https://doi.org/10.52403/ijrr.20230703
Kilany, O. E., Abdelrazek, H. M., Aldayel, T. S., Abdo, S., & Mahmoud, M. M. (2020). Anti-Obesity Potential of Moringa Olifera Seed Extract and Lycopene on High Fat Diet Induced Obesity in Male Sprauge Dawely Rats. Saudi Journal of Biological Sciences, 27(10), 2733-2746.https://doi.org/10.1016/j.sjbs.2020.06.026
Kundimi, S., Kavungala, K. C., Sinha, S., Tayi, V. N. R., Kundurthi, N. R., Golakoti, T., ... & Sengupta, K. (2020). Combined Extracts of Moringa Oleifera, Murraya Koeingii Leaves, and Curcuma Longa Rhizome Increases Energy Expenditure and Controls Obesity in High-Fat Diet-Fed Rats. Lipids in Health and Disease, 19, 1-13.https://doi.org/10.1186/s12944-020-01376-7
Li, L., Ma, L., Wen, Y., Xie, J., Yan, L., Ji, A., ... & Sheng, J. (2022). Crude Polysaccharide Extracted from Moringa Oleifera Leaves Prevents Obesity in Association with Modulating Gut Microbiota in High-Fat Diet-Fed Mice. Frontiers in Nutrition, 9, 861588. https://doi.org/10.3389/fnut.2022.861588
Mabrouki, L., Rjeibi, I., Taleb, J., & Zourgui, L. (2020). Cardiac Ameliorative Effect of Moringa Oleifera Leaf Extract in High-Fat Diet-Induced Obesity in Rat Model. BioMed research international, 2020. https://doi.org/10.1155/2020/6583603
Mendoza-Taco, M. M., Cruz-Hernández, A., Ochoa-Flores, A. A., Hernández-Becerra, J. A., Gómez-Vázquez, A., Moo-Huchin, V. M., ... & Vargas-Bello-Pérez, E. (2022). Physicochemical Characteristics of Yogurt from Sheep Fed with Moringa oleifera Leaf Extracts. Animals, 12(1), 110.https://doi.org/10.3390/ani12010110
Mihanfar, A., Nouri, M., Roshangar, L., & Khadem-Ansari, M. H. (2021). Therapeutic Potential of Quercetin in An Animal Model of PCOS: Possible involvement of AMPK/SIRT-1 axis. European journal of pharmacology, 900, 174062.https://doi.org/10.1016/j.ejphar.2021.174062
Nuraina, N., Azizah, C., Rizkyan, M. A., Zaki, R., & Firdaus, M. R. (2021). Edukasi Pemanfaatan Daun Kelor (Moringa Oleifera) untuk Pemenuhan Nutrisi pada Balita Stunting. Jurnal Peduli Masyarakat, 3(4), 473-480.https://doi.org/10.37287/jpm.v3i4.773
Saleem, H., Al-Dujaily, A. N. G., & Al-murshidi, M. H. H. (2020). Effect of Methanolic Leaf Extract of Moringa Oleiferaon Some Biochemical Markers in Obesity Induced Rats. Research Journal of Pharmaceutical Biological And Chemical ScienceS, 7(3), 2222-2232.
https://www.researchgate.net/publication/304934786_Effect_of_methanolic_leaf_extract_of_Moringa_oleiferaon_some_biochemical_markers_in_obesity_induced_rats
Sivanesan, R. K., Norliza, M., Nancy, F. M., & Azlina, M. F. N. (2022). Preventive Effects of Moringa oleifera on Obesity and Hyperlipidaemia: A Systematic Review. Sains Malaysiana, 51(7), 2159-2171.ins Malaysiana 51(7): 2159–71. http://doi.org/10.17576/jsm-2022-5107-18
WHO. (2022). World Health Statistics. World Health, 1-177. https://reliefweb.int/report/world/world-health-statistics-2022?gad_source=1&gclid=CjwKCAiA_aGuBhACEiwAly57MQf175M791VNr2brLJ1y4uXIBiTXJ0SK3x1ISrrcPBvUnxYtol5qPxoCwEYQAvD_BwE
Wuryandari, M. R. E., Atho'illah, M. F., Laili, R. D., Fatmawati, S., Widodo, N., Widjajanto, E., & Rifa'i, M. (2022). Lactobacillus Plantarum FNCC 0137 Fermented Red Moringa Oleifera Exhibits Protective Effects in Mice Challenged with Salmonella Typhi Via TLR3/TLR4 Inhibition and Down-Regulation of Proinflammatory Cytokines. Journal of Ayurveda and Integrative Medicine, 13(2), 100531. https://doi.org/10.1016/j.jaim.2021.10.003
Caldeira, Camila Amaro et al. (2021). Resveratrol: Change of SIRT 1 and AMPK Signaling Pattern during the Aging Process. Experimental Gerontology 146 111226. https://doi.org/10.1016/j.exger.2021.111226
Denta, Anggeria Oktavisa, and Endang Fauziyah. (2022). Serbuk Daun Kelor Efektif Menurunkan Kadar Glukosa Darah Dan Kadar Kolesterol Pada Individu Obese. Wiraraja Medika: Jurnal Kesehatan 12(1): 10–16. https://doi.org/10.24929/fik.v12i1.1712
El-Shehawi, A. M., Alkafafy, M., El-Shazly, S., Sayed, S., Farouk, S., Alotaibi, S., ... & Ahmed, M. M. (2021). Moringa Oleifera Leaves Ethanolic Extract Ameliorates High Fat Diet-Induced Obesity in Rats. Journal of King Saud University-Science, 33(6), 101552. https://doi.org/10.1016/j.jksus.2021.101552
Farhadipour, M., & Depoortere, I. (2021). The Function of Gastrointestinal Hormones in Obesity—Implications for the Regulation of Energy Intake. Nutrients, 13(6), 1839. https://doi.org/10.3390/nu13061839
Gómez-Martínez, S., Díaz-Prieto, L. E., Castro, I. V., Jurado, C., Iturmendi, N., Martín-Ridaura, M. C., ... & Nova, E. (2021). Moringa Oleifera Leaf Supplementation As A Glycemic Control Strategy in Subjects with Prediabetes. Nutrients, 14(1), 57. .https://doi.org/10.3390/nu14010057
Hidayati, E. N., Kinanti, C. D., & Masrul, M. Z. (2023). Skrining Fitokimia dan Penentuan Kadar Flavonoid Total Ekstrak Etanol Daun Kelor (Moringa oleifera) Menggunakan Metode Spektrofotometer UV-Vis. JIKES: Jurnal Ilmu Kesehatan, 2(1), 14-21.http://qjurnal.my.id/index.php/jik/article/view/642
Kim, D. S., Choi, M. H., & Shin, H. J. (2020). Extracts of Moringa Oleifera Leaves from Different Cultivation Regions Show Both Antioxidant and Antiobesity Activities. Journal of Food Biochemistry, 44(7), e13282. https://doi.org/10.1111/jfbc.13282
Krisanti, S., Darwinata, A. E., & Jawi, I. M. (2023). Oral Administration of Ethanol Extract of Moringa Leaves (Moringa oleifera) Reduces F2-Isoprostane and Monocyte Chemoattractant Protein (MCP-1) Levels in Wistar Rats (Rattus norvegicus) as an Obesity Model. International Journal of Research and Review, 10(7), 12-18 https://doi.org/10.52403/ijrr.20230703
Kilany, O. E., Abdelrazek, H. M., Aldayel, T. S., Abdo, S., & Mahmoud, M. M. (2020). Anti-Obesity Potential of Moringa Olifera Seed Extract and Lycopene on High Fat Diet Induced Obesity in Male Sprauge Dawely Rats. Saudi Journal of Biological Sciences, 27(10), 2733-2746.https://doi.org/10.1016/j.sjbs.2020.06.026
Kundimi, S., Kavungala, K. C., Sinha, S., Tayi, V. N. R., Kundurthi, N. R., Golakoti, T., ... & Sengupta, K. (2020). Combined Extracts of Moringa Oleifera, Murraya Koeingii Leaves, and Curcuma Longa Rhizome Increases Energy Expenditure and Controls Obesity in High-Fat Diet-Fed Rats. Lipids in Health and Disease, 19, 1-13.https://doi.org/10.1186/s12944-020-01376-7
Li, L., Ma, L., Wen, Y., Xie, J., Yan, L., Ji, A., ... & Sheng, J. (2022). Crude Polysaccharide Extracted from Moringa Oleifera Leaves Prevents Obesity in Association with Modulating Gut Microbiota in High-Fat Diet-Fed Mice. Frontiers in Nutrition, 9, 861588. https://doi.org/10.3389/fnut.2022.861588
Mabrouki, L., Rjeibi, I., Taleb, J., & Zourgui, L. (2020). Cardiac Ameliorative Effect of Moringa Oleifera Leaf Extract in High-Fat Diet-Induced Obesity in Rat Model. BioMed research international, 2020. https://doi.org/10.1155/2020/6583603
Mendoza-Taco, M. M., Cruz-Hernández, A., Ochoa-Flores, A. A., Hernández-Becerra, J. A., Gómez-Vázquez, A., Moo-Huchin, V. M., ... & Vargas-Bello-Pérez, E. (2022). Physicochemical Characteristics of Yogurt from Sheep Fed with Moringa oleifera Leaf Extracts. Animals, 12(1), 110.https://doi.org/10.3390/ani12010110
Mihanfar, A., Nouri, M., Roshangar, L., & Khadem-Ansari, M. H. (2021). Therapeutic Potential of Quercetin in An Animal Model of PCOS: Possible involvement of AMPK/SIRT-1 axis. European journal of pharmacology, 900, 174062.https://doi.org/10.1016/j.ejphar.2021.174062
Nuraina, N., Azizah, C., Rizkyan, M. A., Zaki, R., & Firdaus, M. R. (2021). Edukasi Pemanfaatan Daun Kelor (Moringa Oleifera) untuk Pemenuhan Nutrisi pada Balita Stunting. Jurnal Peduli Masyarakat, 3(4), 473-480.https://doi.org/10.37287/jpm.v3i4.773
Saleem, H., Al-Dujaily, A. N. G., & Al-murshidi, M. H. H. (2020). Effect of Methanolic Leaf Extract of Moringa Oleiferaon Some Biochemical Markers in Obesity Induced Rats. Research Journal of Pharmaceutical Biological And Chemical ScienceS, 7(3), 2222-2232.
https://www.researchgate.net/publication/304934786_Effect_of_methanolic_leaf_extract_of_Moringa_oleiferaon_some_biochemical_markers_in_obesity_induced_rats
Sivanesan, R. K., Norliza, M., Nancy, F. M., & Azlina, M. F. N. (2022). Preventive Effects of Moringa oleifera on Obesity and Hyperlipidaemia: A Systematic Review. Sains Malaysiana, 51(7), 2159-2171.ins Malaysiana 51(7): 2159–71. http://doi.org/10.17576/jsm-2022-5107-18
WHO. (2022). World Health Statistics. World Health, 1-177. https://reliefweb.int/report/world/world-health-statistics-2022?gad_source=1&gclid=CjwKCAiA_aGuBhACEiwAly57MQf175M791VNr2brLJ1y4uXIBiTXJ0SK3x1ISrrcPBvUnxYtol5qPxoCwEYQAvD_BwE
Wuryandari, M. R. E., Atho'illah, M. F., Laili, R. D., Fatmawati, S., Widodo, N., Widjajanto, E., & Rifa'i, M. (2022). Lactobacillus Plantarum FNCC 0137 Fermented Red Moringa Oleifera Exhibits Protective Effects in Mice Challenged with Salmonella Typhi Via TLR3/TLR4 Inhibition and Down-Regulation of Proinflammatory Cytokines. Journal of Ayurveda and Integrative Medicine, 13(2), 100531. https://doi.org/10.1016/j.jaim.2021.10.003
Published
2024-06-18
Section
Articles
Copyright (c) 2024 Desty Mahabatillah, Diana Nur Afifah, Adriyan Pramono
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