Literature review Cabai Jawa (Piper Retrofactum Vahl) dalam Proses Penyembuhan Luka
Abstract
This research aims to find out the extent of research that has been carried out and the results obtained regarding the use of Javanese chilies in the wound healing process. The method used in this research is to conduct a literature review. Literature search using Google Scholar, Science Direct and Pubmed databases from 2010 to 2023 with keywords in Indonesian: Javanese chili and wound healing process, and in English with keywords: piper retrofactum vahl, piper longum and wound healing process. Articles were selected using inclusion and exclusion criteria so that the results were 3 (three) articles in Indonesian that were in accordance with the research objectives. The conclusion of this research is that research on the influence of Javanese chilies in the wound healing process is still limited. Administration of Javanese chili extract can help in the wound healing process by increasing the number of macrophages, reducing leukocyte numbers and increasing the thickness of the epithelium in wounds.
Keywords: Java chili, Wound healing, Literature Review
References
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Primadiamanti, A., Saputri, G. A. R., & Nurhasanah, N. (2023). Uji Aktivitas Kombinasi Ekstrak Daun Tapak Dara (Catharanthus Roseus L.G.Don) dan Ekstrak Cabai Jawa (Piper Retrofractum Vahl) sebagai Antioksidan Secara in Vivo. Jurnal Ilmu Kedokteran dan Kesehatan, 10(1), 1355–1363. https://doi.org/10.33024/jikk.v10i1.8717
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Alsareii, S. A., Alzerwi, N. A. N., Alasmari, M. Y., (2023). Manilkara Zapota l. Extract Topical Ointment Application to Skin Wounds in Rats Speeds up the Healing Process. Front. Pharmacol, 14:1206438. https://doi: 10.3389/fphar.2023.1206438
Antoro, W., & Sari, I. M. (2022). Gambaran Tingkat Pengetahuan Ibu tentang Pertolongan Pertama Luka Bakar Anak Usia Toddler. Ulil Albab : Jurnal Ilmiah Multidisiplin, 1(Vol. 1 No. 12: November 2022), 4451–4459. https://ulilalbabinstitute.com/index.php/JIM/article/view/1115/885
Caporali, S., De Stefano, A., Calabrese, C., Giovannelli, A., Pieri, M., Savini, I., Tesauro, M., Bernardini, S., Minieri, M., & Terrinoni, A. (2022). Anti-Inflammatory and Active Biological Properties of the Plant-Derived Bioactive Compounds Luteolin and Luteolin 7-Glucoside. Nutrients, 14(6), 1–19. https://doi.org/10.3390/nu14061155
Chandra, S., Saklani, S., Kumar, P., Kim, B., & Coutinho, H. D. M. (2022). Nutraceuticals: Pharmacologically active Potent Dietary Supplements. BioMed Research International. doi. https://doi.org/10.1155/2022/2051017
Chaughule, R. S., & Barve, R. S. (2023). Role of Herbal Medicines in The Treatment of Infectious Diseases. Vegetos, 37(1), 41–51. https://doi.org/10.1007/s42535-022-00549-2
Dewi, A. U., & Wicaksono, I. A. (2020). Review Artikel: Tanaman Herbal yang Memiliki Aktivitas Penyembuhan Luka. Farmaka, 18(2), 191–207. https://doi.org/10.24198/farmaka.v18i2.27935
Eriksson, E., Liu, P. Y., Schultz, G. S., Martins-Green, M. M., Tanaka, R., Weir, D., Gould, L. J., Armstrong, D. G., Gibbons, G. W., Wolcott, R., Olutoye, O. O., Kirsner, R. S., & Gurtner, G. C. (2022). Chronic wounds: Treatment Consensus. Wound Repair and Regeneration, 30(2), 156–171. https://doi.org/10.1111/wrr.12994
Fernández-Guarino, M., Hernández-Bule, M. L., & Bacci, S. (2023). Cellular and Molecular Processes in Wound Healing. Biomedicines, 11(9). https://doi.org/10.3390/biomedicines11092526
Gomez, S., Anjali, C., Kuruvila, B., Maneesha, P. K., & Joseph, M. (2023). Phytochemical Constitution and Antioxidant Activity of Functional Herbal Drink from Indian Gooseberry (emblica officinalis gaertn.) Fruits Containing Spices and Condiments. Food Production, Processing and Nutrition, 5(1). https://doi.org/10.1186/s43014-022-00127-8
Iskandar, P. F. (2021). Efektivitas Ekstrak Lada Hitam (Piper nigrum L) Terhadap Jumlah dan Motilitas Spermatozoa. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 683–688. https://doi.org/10.35816/jiskh.v10i2.677
Khan, M. I., Karima, G., Khan, M. Z., Shin, J. H., & Kim, J. D. (2022). Therapeutic Effects of Saponins for the Prevention and Treatment of Cancer by Ameliorating Inflammation and Angiogenesis and Inducing Antioxidant and Apoptotic Effects in Human Cells. International Journal of Molecular Sciences, 23(18). https://doi.org/10.3390/ijms231810665
Majnooni, M. B., Fakhri, S., Ghanadian, S. M., Bahrami, G., Mansouri, K., Iranpanah, A., Farzaei, M. H., & Mojarrab, M. (2023). Inhibiting Angiogenesis by Anti-Cancer Saponins: From Phytochemistry to Cellular Signaling Pathways. Metabolites, 13(3). https://doi.org/10.3390/metabo13030323
Okaiyeto, K., & Oguntibeju, O. O. (2021). African Herbal Medicines: Adverse Effects and Cytotoxic Potentials with Different Therapeutic Applications. International Journal of Environmental Research and Public Health. https:// doi.org/10.3390/ijerph18115988
Panphut, W., Budsabun, T., & Sangsuriya, P. (2020). In Vitro Antimicrobial Activity of Piper retrofractum Fruit Extracts against Microbial Pathogens Causing Infections in Human and Animals. International Journal of Microbiology. https://doi.org/10.1155/2020/5638961
Parihar, S., & Sharma, D. (2021). Navagraha (Nine Planets) Plants: The Traditional Uses and The Therapeutic Potential of Nine Sacred Plants of India That Symbolises Nine Planets. IJRAR, 8(4), 96-108. https://www.academia.edu/download/77327521/NAVAGRAHA_NINE_PLANETS_PLANTS_THE_TRADIT.pdf
Primadiamanti, A., Saputri, G. A. R., & Nurhasanah, N. (2023). Uji Aktivitas Kombinasi Ekstrak Daun Tapak Dara (Catharanthus Roseus L.G.Don) dan Ekstrak Cabai Jawa (Piper Retrofractum Vahl) sebagai Antioksidan Secara in Vivo. Jurnal Ilmu Kedokteran dan Kesehatan, 10(1), 1355–1363. https://doi.org/10.33024/jikk.v10i1.8717
Wintoko, R., & Yadika, A. D. N. (2020). Manajemen Terkini Perawatan Luka. Jurnal Kesehatan Universitas Lampung, 4, 183–189. https://juke.kedokteran.unila.ac.id/index.php/JK/article/view/2893
Ro Candra, A. Y., Yanestria, S. M., Mardijanto, A., & Wibisono, F. J. (2022). Pengaruh Ekstrak Daun Salam (Eugenia Polyantha, weight.) Sebagai Alternatif Mempertahankan Kualitas Daging. VITEK : Bidang Kedokteran Hewan, 12(2), 36–40. https://doi.org/10.30742/jv.v12i2.120
Setyawati, A., Wahyuningsih, M. S. H., Nugrahaningsih, D. A. A., Effendy, C., Fneish, F., & Fortwengel, G. (2021). Piper Crocatum Ruiz & Pav. Ameliorates Wound Healing through p53, E-cadherin and SOD1 Pathways on Wounded Hyperglycemia Fibroblasts. Saudi Journal of Biological Sciences, 28(12):7257-7268. https:// doi: 10.1016/j.sjbs.2021.08.039
Sidabutar, L. M. G. B., Lumbantoruan, S. M., & Wardhana, A. D. (2022). Edukasi Luka dan Penanganan Mandiri di Rumah selama Masa Pandemi. Jurnal Kreativitas Pengabdian Kepada Masyarakat (Pkm), 5(11), 3898–3913. https://doi.org/10.33024/jkpm.v5i11.7482
Tatli Cankaya, I. I., & Somuncuoglu, E. I. (2021). Potential and Prophylactic Use of Plants Containing Saponin-Type Compounds as Antibiofilm Agents against Respiratory Tract Infections. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2021/6814215
Tiwari, A., Mahadik, K. R., & Gabhe, S. Y. (2020). Piperine: A Comprehensive Review of Methods of Isolation, Purification, and Biological Properties. Medicine in Drug Discovery, https://doi.org/10.1016/j.medidd.2020.100027
Tottoli, E. M., Dorati, R., Genta, I., Chiesa, E., Pisani, S., & Conti, B. (2020). Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration. Pharmaceutics, 12(8), 1–30. https:// doi:10.3390/pharmaceutics12080735
Tripathi, A. K., Ray, A. K., & Mishra, S. K. (2022). Molecular and Pharmacological Aspects of Piperine as a Potential Molecule for Disease Prevention and Management: Evidence from Clinical Trials. Beni-Suef University Journal of Basic and Applied Sciences, 11(1), 1–24. https://doi.org/10.1186/s43088-022-00196-1
Yang, F., Bai, X., Dai, X., & Li, Y. (2021). The Biological Processes during Wound Healing. Regenerative Medicine, 16(4), 373–390. https://doi.org/10.2217/rme-2020-0066
Zhang, M., Chen, X., Zhang, Y., Zhao, X., Zhao, J., & Wang, X. (2022). The Potential of Functionalized Dressing Releasing Flavonoids Facilitates Scar-Free Healing. Frontiers in Medicine, 9(October), 1–16. https://doi.org/10.3389/fmed.2022.978120
Zulkefli, N., Che Zahari, C. N. M., Sayuti, N. H., Kamarudin, A. A., Saad, N., Hamezah, H. S., Bunawan, H., Baharum, S. N., Mediani, A., Ahmed, Q. U., Ismail, A. F. H., & Sarian, M. N. (2023). Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective. International Journal of Molecular Sciences, 24(5). https://doi.org/10.3390/ijms24054607
Published
2024-03-27
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