Terapi Laser untuk Skar Hipertrofik dan Keloid
Abstract
This study aim to evaluate the success rate of laser therapy in hypertorphic, and keloid scar patients based on scar characteristics. The research method used is systematic review using data from Pubmed, Cochrane Library, Clinicaltrials.gov, and Mendeley from 1994 to July 2022. The results found a total of 28 studies, consisting of 3 retrospective studies, 5 randomized controlled trials (RCT), and 20 prospective studies included in the review. This research evaluated 11 585nm pulse dye laser (PDL) studies, 2 595nm PDL studies, 3 1064 nm Nd:Yag studies, 3 1550nm Er:Yag studies, 3 2940nm Er:Yag studies, and 6 10,600nm fractional CO2 laser studies. In conclusion, the 585 nm pulse dye laser showed the best overall therapeutic success rate. Fractional CO2 10,600nm, Er:YAG 2940nm, and Nd:YAG 1064nm lasers showed the best therapeutic response for reducing erythema, pigmentation, height, and scar consistency. Further research is needed to assess the success rate of therapy.
Keyword: Keloid, Laser, Hypertrophic scar, Systematic Review
References
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Clementoni, M. T., & Azzopardi, E. (2020). Minimally Invasive Technologies for Treatment of HTS and Keloids: Fractional Laser. In Textbook on Scar Management (pp. 279–285). Springer International Publishing. https://doi.org/10.1007/978-3-030-44766-3_33
Deng, H., Tan, T., Luo, G., Tan, J., & Li‐Tsang, C. W. P. (2021). Vascularity and Thickness Changes in Immature Hypertrophic Scars Treated with a Pulsed Dye Laser. Lasers in Surgery and Medicine, 53(7), 914–921. https://doi.org/10.1002/lsm.23366
Elsaie, M. L. (2021). Update on Management of Keloid and Hypertrophic Scars: A systemic review. Journal of Cosmetic Dermatology, 20(9), 2729–2738. https://doi.org/10.1111/jocd.14310
Grabowski, G., Pacana, M. J., & Chen, E. (2020). Keloid and Hypertrophic Scar Formation, Prevention, and Management: Standard Review of Abnormal Scarring in Orthopaedic Surgery. Journal of the American Academy of Orthopaedic Surgeons, 28(10), e408–e414. https://doi.org/10.5435/JAAOS-D-19-00690
Lemperle, G., Schierle, J., Kitoga, K. E., Kassem-Trautmann, K., Sachs, C., & Dimmler, A. (2020). Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification. Plastic and Reconstructive Surgery - Global Open, 8(3), e2582. https://doi.org/10.1097/GOX.0000000000002582
Limandjaja, G. C., Niessen, F. B., Scheper, R. J., & Gibbs, S. (2021). Hypertrophic Scars and Keloids: Overview of the Evidence and Practical Guide for Differentiating between These Abnormal scars. Experimental Dermatology, 30(1), 146–161. https://doi.org/10.1111/exd.14121
Liu, A.-H., Sun, X.-L., Liu, D.-Z., Xu, F., Feng, S.-J., Zhang, S.-Y., Li, L.-Z., Zhou, J.-L., Wang, Y.-T., Zhang, L., Lin, X., Gao, S.-B., Yue, X., Liu, X.-M., Jin, G.-H., & Xu, B. (2023). Epidemiological and Clinical Features of Hypertrophic Scar and Keloid in Chinese College Students: A University-Based Cross-Sectional Survey. Heliyon, 9(4), e15345. https://doi.org/10.1016/j.heliyon.2023.e15345
Nischwitz, S. P., Lumenta, D. B., Spendel, S., & Kamolz, L.-P. (2020). Minimally Invasive Technologies for Treatment of HTS and Keloids: Pulsed-Dye Laser. In Textbook on Scar Management (pp. 263–269). Springer International Publishing. https://doi.org/10.1007/978-3-030-44766-3_31
Ogawa, R. (2020). Long-Pulsed 1064 nm Nd:YAG Laser Treatment for Keloids and Hypertrophic Scars. In Textbook on Scar Management (pp. 271–278). Springer International Publishing. https://doi.org/10.1007/978-3-030-44766-3_32
Oosterhoff, T. C. H., Beekman, V. K., van der List, J. P., & Niessen, F. B. (2021). Laser Treatment of Specific Scar Characteristics in Hypertrophic Scars and Keloid: A Systematic Review. Journal of Plastic, Reconstructive and Aesthetic Surgery, 74(1), 48–64. https://doi.org/10.1016/j.bjps.2020.08.108
Ramadan, H., Saber, M., Salah, M., & Samy, N. (2021). The Effectiveness of Long Pulsed Nd:YAG Laser Alone for Treatment of Keloids and Hypertrophic Scars versus Its Combination with Bleomycin. Journal of Cosmetic Dermatology, 20(12), 3899–3906. https://doi.org/10.1111/jocd.14509
Sahib, N. H., Al-hattab, M. K., Ahmed Fakhry, F., & Jara Atiyah, I. (2020). The Role of Fractional CO 2 Laser in Treatment of Keloid and Hypertrophic Scar used Alone and in Combination with Intralesional Steroids. Indian Journal of Forensic Medicine & Toxicology, 14(3), 1576–1581. https://doi.org/10.37506/ijfmt.v14i3.10638
Tawaranurak, N., Pliensiri, P., & Tawaranurak, K. (2022). Combination of Fractional Carbon Dioxide Laser and Topical Triamcinolone vs Intralesional Triamcinolone for Keloid Treatment: A Randomised Clinical Trial. International Wound Journal, 19(7), 1729–1735. https://doi.org/10.1111/iwj.13775
Tripathi, S., Soni, K., Agrawal, P., Gour, V., Mondal, R., & Soni, V. (2020). Hypertrophic Scars and Keloids: a Review and Current Treatment Modalities. Biomedical Dermatology, 4(1). https://doi.org/10.1186/s41702-020-00063-8
Truong, K., Prasidha, I., & Wain, T. (2022). A Systematic Review of Randomised Controlled Trials Investigating Laser Assisted Drug Delivery for The Treatment of Keloid and Hypertrophic Scars. Lasers in Medical Science, 37(1), 47–59. https://doi.org/10.1007/s10103-021-03296-z
Wang, J., Wu, J., Xu, M., Gao, Q., Chen, B., Wang, F., & Song, H. (2020). Combination Therapy of Refractory Keloid with Ultrapulse Fractional Carbon Dioxide (CO2) Laser and Topical Triamcinolone in Asians--Long‐Term Prevention of Keloid Recurrence. Dermatologic Therapy, 33(6). https://doi.org/10.1111/dth.14359
Betarbet, U., & Blalock, T. W. (2020). Keloids: A Review of Etiology, Prevention, and Treatment. The Journal of Clinical and Aesthetic Dermatology, 13(2), 33–43. https://jcadonline.com/keloids-scars-treatment-review/
Clementoni, M. T., & Azzopardi, E. (2020). Minimally Invasive Technologies for Treatment of HTS and Keloids: Fractional Laser. In Textbook on Scar Management (pp. 279–285). Springer International Publishing. https://doi.org/10.1007/978-3-030-44766-3_33
Deng, H., Tan, T., Luo, G., Tan, J., & Li‐Tsang, C. W. P. (2021). Vascularity and Thickness Changes in Immature Hypertrophic Scars Treated with a Pulsed Dye Laser. Lasers in Surgery and Medicine, 53(7), 914–921. https://doi.org/10.1002/lsm.23366
Elsaie, M. L. (2021). Update on Management of Keloid and Hypertrophic Scars: A systemic review. Journal of Cosmetic Dermatology, 20(9), 2729–2738. https://doi.org/10.1111/jocd.14310
Grabowski, G., Pacana, M. J., & Chen, E. (2020). Keloid and Hypertrophic Scar Formation, Prevention, and Management: Standard Review of Abnormal Scarring in Orthopaedic Surgery. Journal of the American Academy of Orthopaedic Surgeons, 28(10), e408–e414. https://doi.org/10.5435/JAAOS-D-19-00690
Lemperle, G., Schierle, J., Kitoga, K. E., Kassem-Trautmann, K., Sachs, C., & Dimmler, A. (2020). Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification. Plastic and Reconstructive Surgery - Global Open, 8(3), e2582. https://doi.org/10.1097/GOX.0000000000002582
Limandjaja, G. C., Niessen, F. B., Scheper, R. J., & Gibbs, S. (2021). Hypertrophic Scars and Keloids: Overview of the Evidence and Practical Guide for Differentiating between These Abnormal scars. Experimental Dermatology, 30(1), 146–161. https://doi.org/10.1111/exd.14121
Liu, A.-H., Sun, X.-L., Liu, D.-Z., Xu, F., Feng, S.-J., Zhang, S.-Y., Li, L.-Z., Zhou, J.-L., Wang, Y.-T., Zhang, L., Lin, X., Gao, S.-B., Yue, X., Liu, X.-M., Jin, G.-H., & Xu, B. (2023). Epidemiological and Clinical Features of Hypertrophic Scar and Keloid in Chinese College Students: A University-Based Cross-Sectional Survey. Heliyon, 9(4), e15345. https://doi.org/10.1016/j.heliyon.2023.e15345
Nischwitz, S. P., Lumenta, D. B., Spendel, S., & Kamolz, L.-P. (2020). Minimally Invasive Technologies for Treatment of HTS and Keloids: Pulsed-Dye Laser. In Textbook on Scar Management (pp. 263–269). Springer International Publishing. https://doi.org/10.1007/978-3-030-44766-3_31
Ogawa, R. (2020). Long-Pulsed 1064 nm Nd:YAG Laser Treatment for Keloids and Hypertrophic Scars. In Textbook on Scar Management (pp. 271–278). Springer International Publishing. https://doi.org/10.1007/978-3-030-44766-3_32
Oosterhoff, T. C. H., Beekman, V. K., van der List, J. P., & Niessen, F. B. (2021). Laser Treatment of Specific Scar Characteristics in Hypertrophic Scars and Keloid: A Systematic Review. Journal of Plastic, Reconstructive and Aesthetic Surgery, 74(1), 48–64. https://doi.org/10.1016/j.bjps.2020.08.108
Ramadan, H., Saber, M., Salah, M., & Samy, N. (2021). The Effectiveness of Long Pulsed Nd:YAG Laser Alone for Treatment of Keloids and Hypertrophic Scars versus Its Combination with Bleomycin. Journal of Cosmetic Dermatology, 20(12), 3899–3906. https://doi.org/10.1111/jocd.14509
Sahib, N. H., Al-hattab, M. K., Ahmed Fakhry, F., & Jara Atiyah, I. (2020). The Role of Fractional CO 2 Laser in Treatment of Keloid and Hypertrophic Scar used Alone and in Combination with Intralesional Steroids. Indian Journal of Forensic Medicine & Toxicology, 14(3), 1576–1581. https://doi.org/10.37506/ijfmt.v14i3.10638
Tawaranurak, N., Pliensiri, P., & Tawaranurak, K. (2022). Combination of Fractional Carbon Dioxide Laser and Topical Triamcinolone vs Intralesional Triamcinolone for Keloid Treatment: A Randomised Clinical Trial. International Wound Journal, 19(7), 1729–1735. https://doi.org/10.1111/iwj.13775
Tripathi, S., Soni, K., Agrawal, P., Gour, V., Mondal, R., & Soni, V. (2020). Hypertrophic Scars and Keloids: a Review and Current Treatment Modalities. Biomedical Dermatology, 4(1). https://doi.org/10.1186/s41702-020-00063-8
Truong, K., Prasidha, I., & Wain, T. (2022). A Systematic Review of Randomised Controlled Trials Investigating Laser Assisted Drug Delivery for The Treatment of Keloid and Hypertrophic Scars. Lasers in Medical Science, 37(1), 47–59. https://doi.org/10.1007/s10103-021-03296-z
Wang, J., Wu, J., Xu, M., Gao, Q., Chen, B., Wang, F., & Song, H. (2020). Combination Therapy of Refractory Keloid with Ultrapulse Fractional Carbon Dioxide (CO2) Laser and Topical Triamcinolone in Asians--Long‐Term Prevention of Keloid Recurrence. Dermatologic Therapy, 33(6). https://doi.org/10.1111/dth.14359
Published
2024-02-05
Section
Articles
Copyright (c) 2024 Ritchie Santoso, Yuli Kurniawati, Sarah Diba, Rusmawardiana Rusmawardiana, Nopriyati Nopriyati
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