Campuran Produk Berbasis Alami dan Perawatan Mulut Dasar untuk Pengelolaan Mukositis Mulut dan Xerostamia bagi Pasien Kanker
Abstract
This study aims to describe the effectiveness of oral care using mouthwash or using herbal solutions to reduce the severity, value of pain, incidence of mucositis and xerostomia and other oral symptoms such as dysphagia for cancer sufferers. This research method uses a literature review by searching articles in 6 trusted databased such as PubMed, ScienDirect, Scopus, Springer, ProQuest and EBSCHost. The results of this study showed that eleven articles out of thirteen showed the effectiveness of herbal solutiona as mouthwash in reducing mucositis and xerostomia. Two of them are the use of herbal solutions which can reduce xerostomia, bad breath and increase the rate of saliva for those undergoing hemodialysis. In conclusion, oral care interventions using mouthwash and herbal solutions as mouthwash and herbal solutions as mouthwash are effective, safe and can be used to reduce mucositis and xerostamia for cancer patients.
Keywords : Mucositis, Cancer Patients, Oral Care, Xerostomia
References
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Dastan, F., Ameri, A., Dodge, S., Hamidi Shishvan, H., Pirsalehi, A., & Abbasinazari, M. (2020). Efficacy and Safety of Propolis Mouthwash in Management of Radiotherapy Induced Oral Mucositis; A Randomized, Double Blind Clinical Trial. Reports of Practical Oncology and Radiotherapy, 25(6), 969–973. https://doi.org/10.1016/j.rpor.2020.09.012
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Liao, Y. C., Hsu, L. F., Hsieh, L. Y., & Luo, Y. Y. (2021). Effectiveness of Green Tea Mouthwash for Improving Oral Health Status in Oral Cancer Patients: A Single-Blind Randomized Controlled Trial. International Journal of Nursing Studies, 121. https://doi.org/10.1016/j.ijnurstu.2021.103985
Mohammadi, F., Oshvandi, K., Kamallan, S. R., Khazaei, S., Ranjbar, H., Ahmadi-Motamayel, F., Gillespie, M., Jenabi, E., & Vafaei, S. Y. (2022). Effectiveness of Sodium Bicarbonate and Zinc Chloride Mouthwashes in The Treatment of Oral Mucositis and Quality of Life in Patients with Cancer under Chemotherapy. Nursing Open, 9(3), 1602–1611. https://doi.org/10.1002/nop2.1168
Niklander, S. E., Martínez, M., Miranda, A., & Rodriguez, M. (2022). Treatment Alternatives for Dry Mouth: A Scoping Review. Journal of Clinical and Experimental Dentistry, 14(10), 846–853. https://doi.org/10.4317/jced.59912
Oh, M. Y., & Cho, M.-K. (2019). Effects of Gargling with an Aroma Solution on Xerostomia, Halitosis, and Salivary pH in Hemodialysis Patients – A Randomized Controlled Trial. The Open Nursing Journal, 13(1), 1–9. https://doi.org/10.2174/1874434601913010001
Oliver, M. E., & Hinks, T. S. C. (2021). Azithromycin in Viral Infections. In Reviews in Medical Virology 31(2). John Wiley and Sons Ltd. https://doi.org/10.1002/rmv.2163
Oshvandi, K., Vafaei, S. Y., Kamallan, S. R., Khazaei, S., Ranjbar, H., & Mohammadi, F. (2021). Effectiveness of Zinc Chloride Mouthwashes on Oral Mucositis and Weight of Patients with Cancer Undergoing Chemotherapy. BMC Oral Health, 21(1). https://doi.org/10.1186/s12903-021-01706-w
Parkhideh, S., Zeraatkar, M., Moradi, O., Hajifathali, A., Mehdizadeh, M., & Tavakoli-Ardakani, M. (2022). Azithromycin Oral Suspension in Prevention and Management of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Controlled Trial. Supportive Care in Cancer, 30(1), 251–257. https://doi.org/10.1007/s00520-021-06409-0
Piredda, M., Facchinetti, G., Biagioli, V., Giannarelli, D., Armento, G., Tonini, G., & De Marinis, M. G. (2017b). Propolis in The Prevention of Oral Mucositis in Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Pilot Randomised Controlled Trial. European Journal of Cancer Care, 26(6). https://doi.org/10.1111/ecc.12757
Pranadwista, Z. F., & Nur’aeny, N. (2023). Effectiveness of Natural-Based Products for Radiation-Induced Oral Mucositis Therapy: A Systematic Review. In Cancer Treatment and Research Communications, 36. https://doi.org/10.1016/j.ctarc.2023.100720
Rupe, C., Basco, A., Gioco, G., Patini, R., Lucchese, A., Micciché, F., Massaccesi, M., & Lajolo, C. (2023). Sodium-Hyaluronate Mouthwash on Radiotherapy-Induced Xerostomia: A Randomised Clinical Trial. Supportive Care in Cancer, 31(12). https://doi.org/10.1007/s00520-023-08090-x
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Saïz, P., Taveira, N., & Alves, R. (2021). Probiotics in Oral Health and Disease: A Systematic Review. In Applied Sciences (Switzerland), 11(17). https://doi.org/10.3390/app11178070
Shirazian, S., Manifar, S., Kazemian, A., Pourshahidi, S., & Rashtiani, A. (2023). Effectiveness of Green Tea Mouthwash on Radiation-Induced Mucositis in Patients with Head and Neck Cancer: A Randomised Clinical Trial. Australian Journal of Herbal and Naturopathic Medicine, 35(1), 74–78. https://doi.org/10.33235/ajhnm.35.2.74-78
Sidhu, P., Shankargouda, S., Rath, A., Hesarghatta Ramamurthy, P., Fernandes, B., & Kumar Singh, A. (2020). Therapeutic Benefits of Liquorice in Dentistry. In Journal of Ayurveda and Integrative Medicine, 11(1). Elsevier B.V. https://doi.org/10.1016/j.jaim.2017.12.004
van der Meulen, A. I., Neis, E. P. J. G., de Nijs, E. J. M., Coenegracht, B. J. E. G., Stoppelenburg, A., van den Beuken-van Everdingen, M. H. J., & van der Linden, Y. M. (2023). Dry Mouth in Patients with a Life-Limiting Condition or Frailty: A Study Protocol for Two Intervention Studies and A Nested Qualitative Sub-Study (the Dry mOuth Project, DROP). BMC Palliative Care, 22(1). https://doi.org/10.1186/s12904-023-01242-0
Yu, I. C., Tsai, Y. F., Fang, J. T., Yeh, M. M., Fang, J. Y., & Liu, C. Y. (2016). Effects of Mouthwash Interventions on Xerostomia and Unstimulated Whole Saliva Flow Rate Among Hemodialysis Patients: A Randomized Controlled Study. International Journal of Nursing Studies, 63, 9–17. https://doi.org/10.1016/j.ijnurstu.2016.08.009
Zhang, X., Sun, D., Qin, N., Liu, M., Zhang, J., & Li, X. (2020). Comparative Prevention Potential of 10 Mouthwashes on Intolerable Oral Mucositis in Cancer Patients: A Bayesian Network Analysis. Oral Oncology, 107. https://doi.org/10.1016/j.oraloncology.2020.104751
Ameri, A., Heydarirad, G., Choopani, R., Poshtmahi, S., Ameri, P., Talebi, F., Bagheri Pour, A., & Taghizadeh-Hesary, F. (2023). Sumac-Rose Water Mouthwash Versus Benzydamine to Prevent Radiation-Induced Oral Mucositis in Head and Neck Cancers: A Phase II Randomized Trial. Journal of Cancer Research and Clinical Oncology, 149(10), 7427–7439. https://doi.org/10.1007/s00432-023-04687-1
Anh Dao Andreas Bilstein Sabrina Overhagen Lajos Géczi Zoltán Baráth Ralph Mösges, V. (2018). Effectiveness, Tolerability, and Safety of Ectoine-Containing Mouthwash Versus Those of a Calcium Phosphate Mouthwash for The Treatment of Chemotherapy-Induced Oral Mucositis: A Prospective, Active-Controlled, Non-interventional Study. Oncology and Therapy. https://doi.org/10.6084/m9.figshare.6127478
Brookes, Z. L. S., Bescos, R., Belfield, L. A., Ali, K., & Roberts, A. (2020). Current Uses of Chlorhexidine for Management of Oral Disease: A Narrative Review. In Journal of Dentistry (Vol. 103). Elsevier Ltd. https://doi.org/10.1016/j.jdent.2020.103497
Chin, H. L., Chung, K. P., Liu, H. C., Chen, R. S., Chang, H. H., & Chen, M. H. (2023). Efficacy of Polyacrylate Silver Salt/Polyvinylpyrrolidone-Based Liquid Oral Gel in Management of Concurrence Chemoradiotherapy-Induced Oral Mucositis. Journal of the Formosan Medical Association, 122(8), 723–730. https://doi.org/10.1016/j.jfma.2022.12.007
Dastan, F., Ameri, A., Dodge, S., Hamidi Shishvan, H., Pirsalehi, A., & Abbasinazari, M. (2020). Efficacy and Safety of Propolis Mouthwash in Management of Radiotherapy Induced Oral Mucositis; A Randomized, Double Blind Clinical Trial. Reports of Practical Oncology and Radiotherapy, 25(6), 969–973. https://doi.org/10.1016/j.rpor.2020.09.012
Di Fede, O., Canepa, F., Maniscalco, L., Tozzo, P., Matranga, D., & Giuliana, G. (2023). Prevention and The Treatment of Oral Mucositis: The Efficacy of Sodium Bicarbonate Vs Other Agents: A Systematic Review. BMC Oral Health, 23(1). https://doi.org/10.1186/s12903-022-02586-4
Fardad, F., Ghasemi, K., Ansarinejad, N., Khodakarim, N., Nasiripour, S., & Farasatinasab, M. (2023). A Comparative Study to Assess The Effectiveness of Curcumin, Mucosamin, and Chlorhexidine in Chemotherapy-Induced Oral Mucositis. Explore, 19(1), 65–70. https://doi.org/10.1016/j.explore.2022.04.009
Ferreira, A. S., Macedo, C., Silva, A. M., Delerue-Matos, C., Costa, P., & Rodrigues, F. (2022). Natural Products for The Prevention and Treatment of Oral Mucositis—A Review. In International Journal of Molecular Sciences, 23(8). MDPI. https://doi.org/10.3390/ijms23084385
Fleming, M., Craigs, C. L., & Bennett, M. I. (2020). Palliative Care Assessment of Dry Mouth: What Matters Most to Patients with Advanced Disease? Supportive Care in Cancer, 28(3), 1121–1129. https://doi.org/10.1007/s00520-019-04908-9
Guler Avci, G., Erdim, I., Ozmen, Z. C., Gevrek, F., Colak, S., Demirsoy, M. S., & Bozkurt, H. (2022). The Effect of Systemic Application of Propolis on Tongue Damage and Oral Mucositis in Rats Exposed to Radiation. European Archives of Oto-Rhino-Laryngology, 279(2), 1043–1052. https://doi.org/10.1007/s00405-021-07159-9
Hasheminasab, F. S., Hashemi, S. M., Dehghan, A., Sharififar, F., Setayesh, M., Sasanpour, P., Tasbandi, M., & Raeiszadeh, M. (2020). Effects of A Plantago Ovata-Based Herbal Compound in Prevention and Treatment of Oral Mucositis in Patients with Breast Cancer Receiving Chemotherapy: A Double-Blind, Randomized, Controlled Crossover Trial. Journal of Integrative Medicine, 18(3), 214–221. https://doi.org/10.1016/j.joim.2020.02.008
Kim, Y. J. (2023). Xerostomia and Its Cellular Targets. In International Journal of Molecular Sciences, 24(6). https://doi.org/10.3390/ijms24065358
Lee, H. J., Han, D. H., Kim, J. H., & Wu, H. G. (2021). The Effect of Comprehensive Oral Care Program on Oral Health and Quality of Life in Patients Undergoing Radiotherapy for Head and Neck Cancer: A Quasi-Experimental Case-Control Study. Medicine (United States), 100(16), E25540. https://doi.org/10.1097/MD.0000000000025540
Liao, Y. C., Hsu, L. F., Hsieh, L. Y., & Luo, Y. Y. (2021). Effectiveness of Green Tea Mouthwash for Improving Oral Health Status in Oral Cancer Patients: A Single-Blind Randomized Controlled Trial. International Journal of Nursing Studies, 121. https://doi.org/10.1016/j.ijnurstu.2021.103985
Mohammadi, F., Oshvandi, K., Kamallan, S. R., Khazaei, S., Ranjbar, H., Ahmadi-Motamayel, F., Gillespie, M., Jenabi, E., & Vafaei, S. Y. (2022). Effectiveness of Sodium Bicarbonate and Zinc Chloride Mouthwashes in The Treatment of Oral Mucositis and Quality of Life in Patients with Cancer under Chemotherapy. Nursing Open, 9(3), 1602–1611. https://doi.org/10.1002/nop2.1168
Niklander, S. E., Martínez, M., Miranda, A., & Rodriguez, M. (2022). Treatment Alternatives for Dry Mouth: A Scoping Review. Journal of Clinical and Experimental Dentistry, 14(10), 846–853. https://doi.org/10.4317/jced.59912
Oh, M. Y., & Cho, M.-K. (2019). Effects of Gargling with an Aroma Solution on Xerostomia, Halitosis, and Salivary pH in Hemodialysis Patients – A Randomized Controlled Trial. The Open Nursing Journal, 13(1), 1–9. https://doi.org/10.2174/1874434601913010001
Oliver, M. E., & Hinks, T. S. C. (2021). Azithromycin in Viral Infections. In Reviews in Medical Virology 31(2). John Wiley and Sons Ltd. https://doi.org/10.1002/rmv.2163
Oshvandi, K., Vafaei, S. Y., Kamallan, S. R., Khazaei, S., Ranjbar, H., & Mohammadi, F. (2021). Effectiveness of Zinc Chloride Mouthwashes on Oral Mucositis and Weight of Patients with Cancer Undergoing Chemotherapy. BMC Oral Health, 21(1). https://doi.org/10.1186/s12903-021-01706-w
Parkhideh, S., Zeraatkar, M., Moradi, O., Hajifathali, A., Mehdizadeh, M., & Tavakoli-Ardakani, M. (2022). Azithromycin Oral Suspension in Prevention and Management of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Controlled Trial. Supportive Care in Cancer, 30(1), 251–257. https://doi.org/10.1007/s00520-021-06409-0
Piredda, M., Facchinetti, G., Biagioli, V., Giannarelli, D., Armento, G., Tonini, G., & De Marinis, M. G. (2017b). Propolis in The Prevention of Oral Mucositis in Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Pilot Randomised Controlled Trial. European Journal of Cancer Care, 26(6). https://doi.org/10.1111/ecc.12757
Pranadwista, Z. F., & Nur’aeny, N. (2023). Effectiveness of Natural-Based Products for Radiation-Induced Oral Mucositis Therapy: A Systematic Review. In Cancer Treatment and Research Communications, 36. https://doi.org/10.1016/j.ctarc.2023.100720
Rupe, C., Basco, A., Gioco, G., Patini, R., Lucchese, A., Micciché, F., Massaccesi, M., & Lajolo, C. (2023). Sodium-Hyaluronate Mouthwash on Radiotherapy-Induced Xerostomia: A Randomised Clinical Trial. Supportive Care in Cancer, 31(12). https://doi.org/10.1007/s00520-023-08090-x
Sahebnasagh, M., Aksi, V., Eslami, F., Lashkardoost, H., Kasaian, J., Golmohammadzadeh, S., Parkam, B., Negarandeh, R., Saghafi, F., & Sahebnasagh, A. (2023). Prevention of Radiotherapy-Related Oral Mucositis with Zinc and Polyherbal Mouthwash: A Double-Blind, Randomized Clinical Trial. European Journal of Medical Research, 28(1). https://doi.org/10.1186/s40001-023-01015-8
Saïz, P., Taveira, N., & Alves, R. (2021). Probiotics in Oral Health and Disease: A Systematic Review. In Applied Sciences (Switzerland), 11(17). https://doi.org/10.3390/app11178070
Shirazian, S., Manifar, S., Kazemian, A., Pourshahidi, S., & Rashtiani, A. (2023). Effectiveness of Green Tea Mouthwash on Radiation-Induced Mucositis in Patients with Head and Neck Cancer: A Randomised Clinical Trial. Australian Journal of Herbal and Naturopathic Medicine, 35(1), 74–78. https://doi.org/10.33235/ajhnm.35.2.74-78
Sidhu, P., Shankargouda, S., Rath, A., Hesarghatta Ramamurthy, P., Fernandes, B., & Kumar Singh, A. (2020). Therapeutic Benefits of Liquorice in Dentistry. In Journal of Ayurveda and Integrative Medicine, 11(1). Elsevier B.V. https://doi.org/10.1016/j.jaim.2017.12.004
van der Meulen, A. I., Neis, E. P. J. G., de Nijs, E. J. M., Coenegracht, B. J. E. G., Stoppelenburg, A., van den Beuken-van Everdingen, M. H. J., & van der Linden, Y. M. (2023). Dry Mouth in Patients with a Life-Limiting Condition or Frailty: A Study Protocol for Two Intervention Studies and A Nested Qualitative Sub-Study (the Dry mOuth Project, DROP). BMC Palliative Care, 22(1). https://doi.org/10.1186/s12904-023-01242-0
Yu, I. C., Tsai, Y. F., Fang, J. T., Yeh, M. M., Fang, J. Y., & Liu, C. Y. (2016). Effects of Mouthwash Interventions on Xerostomia and Unstimulated Whole Saliva Flow Rate Among Hemodialysis Patients: A Randomized Controlled Study. International Journal of Nursing Studies, 63, 9–17. https://doi.org/10.1016/j.ijnurstu.2016.08.009
Zhang, X., Sun, D., Qin, N., Liu, M., Zhang, J., & Li, X. (2020). Comparative Prevention Potential of 10 Mouthwashes on Intolerable Oral Mucositis in Cancer Patients: A Bayesian Network Analysis. Oral Oncology, 107. https://doi.org/10.1016/j.oraloncology.2020.104751
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2024-04-01
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Copyright (c) 2024 Entin Prakartini, Enie Novieastari, Dewi Gayatri
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