Efektivitas Ekstrak Batang Arcangelisia flava Merr. sebagai Afrodisiaka pada Mencit Jantan dan Betina
Abstract
This study aimed to analyze the effect of the stem extract of the yellow root plant (Arcangelisia flava Merr.) from Enggano Island on the introduction and locomotor activity of male and female mice (Mus musculus L.). The method used is an experiment with a completely randomized design. The treatment variations were extracted at a dose of 150 mg/kgBW, 200 mg/kgBW and 250 mg/kgBW, Neo Hormoviton capsules at a 200 mg/kgBW dose as a positive control, and without extract or strong drug as a negative control. The results showed that the administration of the extract caused an increase in the introduction activity, but the activity decreased with the increase in the dose of the given extract. Meanwhile, an increase in locomotor activity occurred at a dose of 250 mg/kgBW, while the doses of 150 mg/kgBW and 200 mg/kgBW tended to cause a decrease. Duncan's further test showed that a dose of 250 mg/kgBW increased locomotor activity which was more significant in female mice but not significantly in male mice. In conclusion, the extract at a dose of 250 mg/kgBW can increase locomotor activity, higher than Neo Hormoviton capsules at 200 mg/kgBW in both male and female mice.
Keywords: Aphrodisiac, Sexual Activity, Arcangelisia flava, Fitness
References
Diliarosta, S., Sudarmin, Efendi, A., Dillasamola, D., Oktomalioputri, B., & Ramadhani, R. (2021). Reconstruction and Scientific Explanation of akar Kuning (Arcangelisia flava Merr.) from West Sumatra as Ethnomedicine and Source of Science Learning. Pharmacognosy Journal, 13(1), 206–211. https://doi.org/10.5530/pj.2021.13.29
Fatmawati, F., Susilawati, S., Oswari, L. D., Dzakiyah, D., Anindita, F. (2020). Uji Aktivitas Antidiabetes Akar Kayu Kuning (Arcangelisia flava). Jurnal Kedokteran dan Kesehatan, 7(3), 35-39. https://doi.org/10.32539/JKK.V7I3.10190
Fatmawati, F., Susilawati, S., Oswari, L. D., Fadiya, F., & Nadya, N. (2021). Uji Aktivitas Penghambatan Enzim α-glucosidase Ekstrak Air dan Ekstrak Etanol Kayu Kuning (Arcangelisia flava). Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 8(1), 53–60. https://doi.org/10.32539/v8i1.13118
Fauzi, F., Widodo, H., & Haryanti, S. (2019). Kajian Tumbuhan Obat yang Banyak Digunakan untuk Aprodisiaka oleh Beberapa Etnis Indonesia. Media Penelitian dan Pengembangan Kesehatan, 29(1), 51–64. https://doi.org/10.22435/mpk.v29i1.466
Ghasemi, M. (2019). Nitric Oxide: Antidepressant Mechanisms and Inflammation. Advances in Pharmacology, 86, 121–152. https://doi.org/10.1016/bs.apha.2019.04.004
Goel, B., & Maurya, N. K. (2020). Aphrodisiac Herbal Therapy for Erectile Dysfunction. Archives of Pharmacy Practice, 11(1), 1–6. https://archivepp.com/article/aphrodisiac-herbal-therapy-for-erectile-dysfunction
Marpaung, M. P., & Handayani, D. W. (2018). The Effect of Solvent Concentration on Antioxidant Activity of Akar Kuning (Fibraurea chloroleuca Miers) Extract. AIP Conference Proceedings, 2049, 1–5. https://doi.org/10.1063/1.5082504
Maryani, M., & Rosdiana, R. (2020). Peranan Imunostimulan Akar Kuning Arcangelisia flava Merr pada Gambaran Aktivasi Sistem Imun Ikan Mas (Cyprinus carpio L). Jurnal Akuakultur Rawa Indonesia, 8(1), 22–36. https://doi.org/10.36706/jari.v8i1.10328
Maryani, M., Rosita, R., Monalisa, S. S., & Rozik, M. (2018). In Vitro Test of Natural Antibacterial Activity of Yellow-Fruit Moonseed Arcangelisia flava Merr. Leaf on Bacterium Pseudomonas fluorescens Under Different Doses. AACL Bioflux, 11(1), 288–294. http://www.bioflux.com.ro/docs/2018.288-294.pdf
Mutiah, R., Kirana, F. O., Annisa, R., Rahmawati, A., & Sandra, F. (2020). Extract of Yellow Root (Arcangelisia flava (L.) Merr.) from Several Regions in Kalimantan: Alkaloid Content and Cytotoxicity towards WiDr Colorectal Cancer Cells. Indonesian Journal of Cancer Chemoprevention, 11(2), 84–89. https://doi.org/10.14499/indonesianjcanchemoprev11iss2pp84-89
Pramono, S., Paramawidhita, R. Y. T., Marini, M., & Bahri, M. S. (2019). Subchronic Effect of Yellow Root Arcangelisia flava L Merr. Containing Berberine Boiled with Water and Brackish Water. International Journal of Trend in Scientific Research and Development (IJTSRD) International Journal of Trend in Scientific Research and Development, 3(5), 2569–2573. https://doi.org/https://doi.org/10.31142/ijtsrd26484
Pramono, S., Paramidhita, R. Y. T., Marini, M., & Bachri, M. S. (2020). Comparative Effects of Yellow Root (Arcangelisia flava (L.) Merr.) Decoctions with Water and Brackish Water on Kidneys and Uterus in Wistar Rats. Majalah Obat Tradisional, 25(2), 116–120. https://doi.org/10.22146/mot.55178
Pratama, M. R. F., Suratno, S., & Mulyani, E. (2018). Antibacterial Activity of Akar Kuning (Arcangelisia flava) Secondary Metabolites: Molecular Docking Approach. Asian Journal Pharmaceutical and Clinical Reearchs, 11(11), 447-451. https://doi.org/10.22159/ajpcr.2018.v11i11.29189
Setyani, W., Setyowati, H., Palupi, D. H. S., Rahayunnissa, H., & Hariono, M. (2019). Antihyperlipidemia and Antihyperglycemic Studies of Arcangelisia flava (L.) Merr. Phenolic Compound: Incorporation of In Vivo and In Silico Study at Molecular Level. Indonesian Journal of Pharmaceutical Science and Technology, 6(2), 84–94. https://doi.org/10.24198/ijpst.v6i2.20211
