Kekentalan Darah Tikus Putih (Rattus norvegicus) Strain Wistar Bunting yang Mengkonsumsi MSG Organik dan Sintetis Dosis 60-120 mg/kg
DOI:
https://doi.org/10.31539/bioedusains.v8i1.13156Abstract
This study aims to determine blood viscosity in pregnant Wistar strain rats given organic MSG and synthetic MSG with dose treatment. This research is a descriptive quantitative study using an experimental method and a Completely Randomized Design (CRD) consisting of 4 treatments with 3 replications each. Groups P1 and P2 were given organic MSG, while groups P4 and P5 were given synthetic MSG. The obtained data were statistically analyzed using One-Way Analysis of Variance (ANOVA) with SPSS version 20, followed by the DMRT (Duncan’s Multiple Range Test). The results showed that the P1 group with organic MSG had an average blood clotting time of 16.39 minutes, P2 was 14.39 minutes, P4 with synthetic MSG was 7.87 minutes, and P5 was 9.33 minutes. In conclusion, the blood viscosity of pregnant Wistar strain white rats (Rattus norvegicus) after being treated with organic and synthetic MSG shows that the consumption of both types of MSG can reduce blood viscosity levels, as evidenced by the slowing of blood clotting time. The effective dose of organic and synthetic MSG consumption is 120 mg/kg.
Keywords: Blood Viscosity, Pregnancy, Organic MSG, Synthetic MSG, Wistar Strain Rats
References
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Wulansari, R., & Wahdaniah, S. (2019). Perbedaan nilai masa pembekuan darah (clotting time) dengan menggunakan tabung kaca dan tabung plastik metode Lee and White. Jurnal Laboratorium Khatulistiwa, 2(2), 64–66. https://doi.org/10.30602/jlk.v2i2.333
Badriyah, L. (2019). Edukasi penggunaan monosodium glutamat (MSG) dalam makanan serta efeknya bagi kesehatan. Journal of Community Engagement and Empowerment, 1(2), 84–87. http://ojs.iik.ac.id/index.php/JCEE
Brahmananda, W. G. A., Sudisma, I. G. N., Kendran, A. A. S., & Sudira, I. W. (2023). Profil hematologi tikus putih (Rattus norvegicus) yang diberi salep simplisia daun kembang sepatu (Hibiscus rosa-sinensis L.) setelah dipapar sinar ultraviolet. Jurnal Sain Veteriner, 41(2), 226. https://doi.org/10.22146/jsv.82701
Elnaga, A. N. (2019). Teratogenicity of monosodium glutamate on the pregnant rats and their fetuses. The Egyptian Journal of Hospital Medicine, 74(8), 1737–1747. www.belphotonics.com
Ernawati, A. (2017). Masalah gizi pada ibu hamil. Jurnal Litbang, 13(1), 60–69. https://doi.org/10.33658/jl.v13i1.93
Food and Drug Administration. (2012, November 19). Questions and answers on monosodium glutamate (MSG). U.S. Food and Drug Administration. https://www.fda.gov/food/food-additives-petitions/questions-and-answers-monosodium-glutamate-msg
Hasanah, A. (2015). Efek jus bawang bombay (Allium cepa Linn.) terhadap motilitas spermatozoa mencit yang diinduksi streptozotocin (STZ). Saintika Medika, 11(2), 92–101. https://doi.org/10.22219/sm.v11i2.4203
Indrasari, N., & Agustina, F. (2021). Tempe dapat meningkatkan kadar hemoglobin (Hb) pada ibu hamil. Jurnal Kebidanan Malahayati, 7(4), 857–864. http://ejurnalmalahayati.ac.id/index.php/kebidanan
Kodali, B. S., Karuppiah, A., Bharadwaj, S., Chow, J., & Tanaka, K. (2022). Efficacy of sonorheometry point of care device in determining low fibrinogen levels in pregnant blood: An in vitro dilution and reconstitution study. Journal of Clinical Monitoring and Computing, 36(5), 1423–1431. https://doi.org/10.1007/s10877-021-00782-1
Kurtanty, D., Faqih, D. M., & Upa, N. P. (2019). Review monosodium glutamat: How to understand it properly. Journal of Chemical Information and Modeling.
Munasiah, M. (2020). Impact of giving monosodium glutamate on health. Jurnal Penelitian Perawat Profesional, 2(4), 451–458. http://jurnal.globalhealthsciencegroup.com/index.php/JPPP
Mutmainnah, K., & Muthmainnah, M. (2023). Pengaruh program belajar ilmu takaran MSG (BELI TAUGE) dalam meningkatkan pengetahuan masyarakat tentang hipertensi. Prosiding Seminar Nasional Kesehatan Masyarakat Universitas Muhammadiyah Surakarta.
Nasirotuzahroh, U., & Susanti, R. (2023). Uji aktivitas fibrinolitik jus cacing tanah (Lumbricus rubellus) pada tikus yang diberi asam traneksamat. Indonesian Journal of Mathematics and Natural Science, 46(1), 1–9. http://journal.unnes.ac.id/nju/index.php/JM
Prasetyaningsih, Y., Sari, M. W., & Ekawandani, N. (2018). Pengaruh suhu pengeringan dan laju alir udara terhadap analisis proksimat penyedap rasa alami berbahan dasar jamur untuk aplikasi makanan sehat (batagor). Eksergi, 15(2), 41–47. https://doi.org/10.31315/e.v15i2.2383
Rahimah, S., Salampe, M., & Rahmania, N. (2020). Uji toksisitas teratogenik ekstrak etanol daun asam jawa (Tamarindus indica Linn.) terhadap tikus (Rattus norvegicus). Jurnal Ilmiah As-Syifaa, 12(1), 29–35.
Ranucci, M., Laddomada, T., & Baryshnikova, E. (2014). Blood viscosity during coagulation at different shear rates. Physiological Reports, 2(7). https://doi.org/10.14814/phy2.12065
Shosha, H. M., Ebaid, H. M., Toraih, E. A., Abdelrazek, H. M. A., & Elrayess, R. A. (2023). Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar albino rats. Environmental Science and Pollution Research, 30(17), 49779–49797. https://doi.org/10.1007/s11356-023-25661-x
Sloop, G. D., Holsworth, R., & Weidman, J. (2013). Review of major epidemiological studies of blood viscosity in cardiovascular diseases. Integrative Medicine, 12(6), 24. https://www.researchgate.net/publication/320108174
Vricella, L. K. (2017). Emerging understanding and measurement of plasma volume expansion in pregnancy. American Journal of Clinical Nutrition, 106, 1620–1625. https://doi.org/10.3945/ajcn
Wicaksono, M. G., Prabowo, K. A. D., Salsabila, A. F., Tias, E. P. A. N., & Hayati, L. R. (2022). Hidrolisat tempe dengan bromelin ekstrak nanas sebagai inovasi MSG organik.
Widodo, S., Rachmayanti, R. A., Zahran, A., & Haqq, N. (2024). Peranan MSG tempe, nanas, dan bayam untuk pemenuhan gizi baik. Jurnal Ilmiah Multidisiplin, 2(5), 102–106. https://doi.org/10.5281/zenodo.11354979
Wulansari, R., & Wahdaniah, S. (2019). Perbedaan nilai masa pembekuan darah (clotting time) dengan menggunakan tabung kaca dan tabung plastik metode Lee and White. Jurnal Laboratorium Khatulistiwa, 2(2), 64–66. https://doi.org/10.30602/jlk.v2i2.333
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2025-02-28
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