Meta-Sintesis Kualitatif Studi Klinis: Efektivitas Reperfusi Primer dan Farmakoinvasif pada Pasien Stemi

Authors

  • Vera Uliana Simanjuntak Rumah Sakit Bhayangkara Tarakan
  • Janet Edrina Ung Instansi Pusat Kesehatan Masyarakat Biudukfoho Nusa Tenggara Timur
  • Widodo Darmo Sentono Rumah Sakti Daerah dr H Soemarno Sostroatmodjo Tanjung Selor Bulungan

DOI:

https://doi.org/10.31539/4rak9s93

Abstract

This study aims to compare the effectiveness of two reperfusion strategies in patients with ST-Elevation Myocardial Infarction (STEMI), namely primary percutaneous coronary intervention (PPCI) and the pharmaco-invasive strategy. The method used is a qualitative meta-synthesis with thematic analysis of clinical studies obtained from various scientific databases. The results show that primary reperfusion is superior in reducing mortality and complications when performed within the optimal timeframe (<120 minutes). However, the pharmaco-invasive strategy serves as an effective alternative in areas with limited PCI access, showing comparable clinical outcomes when applied according to time protocols. In conclusion, reperfusion strategy selection must align with the availability of resources and healthcare infrastructure.

 

Keywords: Effectiveness, Meta-Synthesis, Pharmaco-Invasive, Primary Reperfusion, STEMI

References

Armstrong, P. W., Gershlick, A. H., Goldstein, P., Wilcox, R., Danays, T., Lambert, Y., … Désilets, V. (2013). Fibrinolysis or primary PCI in ST segment elevation myocardial infarction. The New England Journal of Medicine, 368(15), 1379–1387. https://doi.org/10.1056/NEJMoa1301092

Bagai, A., Tan, M., Di Mario, C., et al. (2014). Routine invasive management early after fibrinolysis: relationship between baseline risk and treatment effects in a pooled patient level analysis of 7 randomized controlled trials. American Heart Journal, 168(6), 757–765. https://doi.org/10.1016/j.ahj.2014.07.027

Elbadawi, A., Elzeneini, M., Elgendy, I. Y., Megaly, M., Omer, M., Jimenez, E., Ghanta, R. K., Brilakis, E. S., & Jneid, H. (2023). Coronary artery bypass grafting after acute ST-elevation myocardial infarction. Journal of Thoracic and Cardiovascular Surgery, 165(2), 672–683.e10. https://doi.org/10.1016/j.jtcvs.2021.03.081

Hasiholan, T. P., Pratami, R., & Wahid, U. (2020). Pemanfaatan media sosial TikTok sebagai media kampanye gerakan cuci tangan di Indonesia untuk mencegah COVID-19. Communiverse: Jurnal Ilmu Komunikasi, 5(2), 70–80. https://doi.org/10.36341/cmv.v5i2.1278

Moleong, L. J. (1989). Metodologi penelitian kualitatif. Remaja Rosdakarya.

Nugroho, P., Kohar, K., Noor, C. A., & Sutranto, A. L. (2022). Comparison between the World Health Organization (WHO) and International Society of Hypertension (ISH) guidelines for hypertension. Annals of Medicine, 54(1), 837–845.

Suryagama, D., Sari, D. P., & Mukti, A. W. (2023). Evaluasi penggunaan obat rasional berdasarkan indikator World Health Organization (WHO) di puskesmas. FARMASIS: Jurnal Sains Farmasi, 4(1), 32–41. https://doi.org/10.36456/farmasis.v4i1.7090

Downloads

Published

2025-08-03