Pengaruh Pemberian Ekstrak Buah Gandaria terhadap Profil Darah Tikus yang Diinduksi Karbon Tetraklorida

Muhammad zaharul ichsan; syafruddin  Ilyas; Masitta Tanjung

doi:10.31539/pb7cvp76

Authors

Muhammad Zaharul Ichsan, S.Si Universitas Sumatera Utara https://orcid.org/0000-0002-1321-4898
Prof. Dr. Syafruddin Ilyas, M.Biomed Universitas Sumatera Utara https://orcid.org/0000-0003-2760-2901
Dr. Masitta tanjung, M.Si. Universitas Sumatera Utara https://orcid.org/0000-0003-4269-2677

DOI:

https://doi.org/10.31539/pb7cvp76

Abstract

This study aims to analyze the antioxidant potential of gandaria fruit extract against carbon tetrachloride-induced free radicals based on complete blood profile analysis in experimental animals. The method used was a completely randomized design with 30 rats divided into six treatment groups, namely normal, negative, positive, and three gandaria fruit extract treatment groups at doses of 200, 400, and 600 mg/kg BW. The results showed that gandaria fruit extract had a significant effect in improving blood profile damage after CCl4 induction, contained alkaloids, flavonoids, steroids, terpenoids, saponins, and tannins, had total phenolic content of 6133 mg/kg, antioxidant inhibition activity of 81%, and an IC50 value of 90 ppm. In conclusion, gandaria fruit extract at a dose of 600 mg/kg BW was the best dose and showed potential as a hematoprotective agent.

Keywords: Blood Profile, Bouea Macrophylla, Carbon Tetrachloride, Plum Mango.

Author Biographies

Muhammad Zaharul Ichsan, S.Si, Universitas Sumatera Utara

Mahasiswa, Prodi magister biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas sumatera utara
Prof. Dr. Syafruddin Ilyas, M.Biomed, Universitas Sumatera Utara

Dosen, Prodi magister biologi, fakultas matematika dan ilmu pengetahuan alam, universitas sumatera utara
Dr. Masitta tanjung, M.Si., Universitas Sumatera Utara

Dosen, Prodi magister biologi, fakultas matematika dan ilmu pengetahuan alam, universitas sumatera utara

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